2024
Crystal Structure of Bimekizumab Fab Fragment in Complex with IL-17F Provides Molecular Basis for Dual IL-17A and IL-17F Inhibition
Adams R, Bunick C, Lawson A, Gomez B, Shaw S. Crystal Structure of Bimekizumab Fab Fragment in Complex with IL-17F Provides Molecular Basis for Dual IL-17A and IL-17F Inhibition. Journal Of Investigative Dermatology 2024, 144: 2581-2583.e2. PMID: 38631666, DOI: 10.1016/j.jid.2024.03.037.Peer-Reviewed Original ResearchCrystal structureMolecular basis
2006
Biochemical and Structural Domain Analysis of Xeroderma Pigmentosum Complementation Group C Protein †
Bunick CG, Miller MR, Fuller BE, Fanning E, Chazin WJ. Biochemical and Structural Domain Analysis of Xeroderma Pigmentosum Complementation Group C Protein †. Biochemistry 2006, 45: 14965-14979. PMID: 17154534, PMCID: PMC2579963, DOI: 10.1021/bi061370o.Peer-Reviewed Original ResearchConceptsXPC functionXeroderma pigmentosum complementation group C proteinFirst functional roleComplementation group C proteinFunctional roleProtease protection assaysStructural domain analysesFull-length proteinXeroderma pigmentosum (XP) diseaseLimited proteolysis experimentsN-terminal portionMultidomain proteinsGlobal genomeMutational defectsProtein interactionsAberrant DNAC-terminal fragmentMolecular basisExcision repairProteolysis experimentsBiochemical characterizationC proteinSequence analysisStructural domainsProtection assays