2014
Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle
Sinha M, Jang Y, Oh J, Khong D, Wu E, Manohar R, Miller C, Regalado S, Loffredo F, Pancoast J, Hirshman M, Lebowitz J, Shadrach J, Cerletti M, Kim M, Serwold T, Goodyear L, Rosner B, Lee R, Wagers A. Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle. Science 2014, 344: 649-652. PMID: 24797481, PMCID: PMC4104429, DOI: 10.1126/science.1251152.Peer-Reviewed Original ResearchConceptsGDF11 levelsSystemic delivery of recombinant proteinsAged miceSkeletal muscleStem cell dysfunctionAged muscle stem cellsDelivery of recombinant proteinsMuscle stem cellsGrowth differentiation factor 11Differentiation factor 11Parabiosis experimentsSystemic deliveryMouse skeletal muscleImpaired regenerationSatellite cellsCell dysfunctionExercise capacityHeterochronic parabiosisYoung bloodStem cellsFactor 11Regenerative functionMiceMuscle agingRejuvenation factor
2012
Induction of Histiocytic Sarcoma in Mouse Skeletal Muscle
Liu J, Hettmer S, Milsom M, Hofmann I, Hua F, Miller C, Bronson R, Wagers A. Induction of Histiocytic Sarcoma in Mouse Skeletal Muscle. PLOS ONE 2012, 7: e44044. PMID: 22952867, PMCID: PMC3432091, DOI: 10.1371/journal.pone.0044044.Peer-Reviewed Original ResearchConceptsMyeloid sarcomaAcute myeloid leukemiaBone marrowHistiocytic sarcomaAccumulation of immature myeloid cellsDiagnosis of acute myeloid leukemiaEvidence of pathologic involvementEx vivo transductionImmature myeloid cellsLeukemia-initiating cellsNon-hematopoietic organsBone marrow cellsHematopoietic lineage markersSarcoma-bearing miceTumor-bearing animalsSkeletal muscleInduce tumor formationImmunocompromised NODSecondary transplantationMyeloid leukemiaPeripheral bloodMarrow cellsMyeloid cellsAbsent expressionIntravenous transplantation