2021
Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group
Rossetti MG, Patalay P, Mackey S, Allen NB, Batalla A, Bellani M, Chye Y, Cousijn J, Goudriaan AE, Hester R, Hutchison K, Li CR, Martin-Santos R, Momenan R, Sinha R, Schmaal L, Sjoerds Z, Solowij N, Suo C, van Holst RJ, Veltman DJ, Yücel M, Thompson PM, Conrod P, Garavan H, Brambilla P, Lorenzetti V. Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group. NeuroImage Clinical 2021, 30: 102636. PMID: 33857771, PMCID: PMC8065340, DOI: 10.1016/j.nicl.2021.102636.Peer-Reviewed Original ResearchConceptsENIGMA Addiction Working GroupAlcohol dependenceNeuroanatomical differencesAlcohol-dependent menSmaller amygdala volumesGlobal brain measuresGender-related differencesClinical outcomesControl menCorpus callosumAmygdala volumeNeurobiological effectsGM volumeGender differencesSmaller amygdalaStandard drinksBrain regionsIntracranial volumeWorking GroupTotal GMBrain measuresCerebellar GMNeurobiological substratesWomenEducation years
2005
Neuroimaging study of sex differences in the neuropathology of cocaine abuse
Li CS, Kemp K, Milivojevic V, Sinha R. Neuroimaging study of sex differences in the neuropathology of cocaine abuse. Gender Medicine 2005, 2: 174-182. PMID: 16290890, DOI: 10.1016/s1550-8579(05)80046-4.Peer-Reviewed Original ResearchConceptsRegional brain activationBrain activationGreater activationBrain regionsSex differencesScript-guided imagerySubstance abusersCerebral perfusion deficitsBlood oxygenation level-dependent (BOLD) signalSame statistical thresholdCocaine-dependent menCue-induced cravingSuperior frontal gyrusLevel-dependent signalChronic cocaine useMale substance abusersSex-related factorsCocaine use disorderImportant sex differencesLeft uncusStress trialsClinical outcomesPerfusion deficitsRight claustrumPharmacologic challenge