2018
High-resolution cryo-EM structures of actin-bound myosin states reveal the mechanism of myosin force sensing
Mentes A, Huehn A, Liu X, Zwolak A, Dominguez R, Shuman H, Ostap EM, Sindelar CV. High-resolution cryo-EM structures of actin-bound myosin states reveal the mechanism of myosin force sensing. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 1292-1297. PMID: 29358376, PMCID: PMC5819444, DOI: 10.1073/pnas.1718316115.Peer-Reviewed Original ResearchConceptsN-terminal subdomainHigh-resolution cryo-EM structuresADP stateNear-atomic resolution structuresCryo-EM structureCryo-electron microscopyHigh-resolution structuresIsoform-dependent mannerFilamentous actinResolution structureStructural basisMyosin IBActin filamentsStructural diversityRelease pathwayADP releaseActinPointed endPotent stabilizerMyosin
2017
Structural basis of cooperativity in kinesin revealed by 3D reconstruction of a two-head-bound state on microtubules
Liu D, Liu X, Shang Z, Sindelar CV. Structural basis of cooperativity in kinesin revealed by 3D reconstruction of a two-head-bound state on microtubules. ELife 2017, 6: e24490. PMID: 28504639, PMCID: PMC5459574, DOI: 10.7554/elife.24490.Peer-Reviewed Original Research
2011
An adaptation of the Wiener filter suitable for analyzing images of isolated single particles
Sindelar CV, Grigorieff N. An adaptation of the Wiener filter suitable for analyzing images of isolated single particles. Journal Of Structural Biology 2011, 176: 60-74. PMID: 21757012, PMCID: PMC3184790, DOI: 10.1016/j.jsb.2011.06.010.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsCryoelectron MicroscopyFourier AnalysisImage Processing, Computer-AssistedModels, MolecularProtein ConformationSignal-To-Noise RatioConceptsWiener filterConventional Wiener filterCryo-EM applicationsNew filterFourier ring correlationParticle areaEstimation schemeFilterLeast-squares senseEstimation methodNoise ratioSpecific applicationsSingle particleParticlesImage fieldError reductionNumeric testsApplicationsImaging conditionsSimulated dataInput data
2010
An atomic-level mechanism for activation of the kinesin molecular motors
Sindelar CV, Downing KH. An atomic-level mechanism for activation of the kinesin molecular motors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 4111-4116. PMID: 20160108, PMCID: PMC2840164, DOI: 10.1073/pnas.0911208107.Peer-Reviewed Original Research
2003
Thermodynamic Properties of the Kinesin Neck-Region Docking to the Catalytic Core
Rice S, Cui Y, Sindelar C, Naber N, Matuska M, Vale R, Cooke R. Thermodynamic Properties of the Kinesin Neck-Region Docking to the Catalytic Core. Biophysical Journal 2003, 84: 1844-1854. PMID: 12609886, PMCID: PMC1302753, DOI: 10.1016/s0006-3495(03)74992-3.Peer-Reviewed Original Research
1998
Effects of salt bridges on protein structure and design
Sindelar C, Hendsch Z, Tidor B. Effects of salt bridges on protein structure and design. Protein Science 1998, 7: 1898-1914. PMID: 9761471, PMCID: PMC2144171, DOI: 10.1002/pro.5560070906.Peer-Reviewed Original ResearchMeSH KeywordsModels, MolecularMolecular Sequence DataMutationProtein ConformationProteinsSaltsStatic Electricity