2024
A Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder
Kiluk B, Benitez B, DeVito E, Frankforter T, LaPaglia D, O’Malley S, Nich C. A Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder. JAMA Network Open 2024, 7: e2435205. PMID: 39325452, PMCID: PMC11428014, DOI: 10.1001/jamanetworkopen.2024.35205.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyDigital cognitive behavioral therapyAlcohol use disorderAlcohol useCBT programUse disorderCognitive behavioral therapy programCurrent alcohol use disorderTreatment-seeking adultsBehavioral therapy programEvidence-based treatmentsBaseline to 6-month follow-upRates of alcohol useReducing alcohol useTreatment periodRandomized clinical trialsBehavioral therapyOutpatient substancePercentage of daysOutpatient treatmentIntention-to-treat analysisIndividual counselingStudy periodFollow-upIntention-to-treatCognitive processing therapy (CPT) versus individual drug counseling (IDC) for PTSD for veterans with opioid use disorder maintained on buprenorphine
Petrakis I, Meshberg‐Cohen S, Nich C, Kelly M, Claudio T, Jane J, Pisani E, Ralevski E. Cognitive processing therapy (CPT) versus individual drug counseling (IDC) for PTSD for veterans with opioid use disorder maintained on buprenorphine. American Journal On Addictions 2024, 33: 525-533. PMID: 38624259, DOI: 10.1111/ajad.13557.Peer-Reviewed Original ResearchCognitive processing therapyIndividual drug counselingPosttraumatic stress disorderOpioid use disorderSubstance use disordersDrug counselingProcessing therapyPTSD symptomsUse disorderCognitive processing therapy groupEvidence-based trauma-focused psychotherapiesSelf-reported PTSD symptomsPosttraumatic stress disorder symptomsPosttraumatic stress disorder treatmentRemission of PTSD symptomsPosttraumatic Stress Disorder ChecklistComorbid opioid use disorderTrauma-focused psychotherapyTrauma-focused treatmentRates of comorbidityTreatment group differencesPCL-5Stress disorderGroup differencesRandomized clinical trialsEfficacy of Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT) in Individuals With Chronic Pain and Opioid Use Disorder: Protocol for a Randomized Clinical Trial of a Digital Cognitive Behavioral Treatment
MacLean R, Ankawi B, Driscoll M, Gordon M, Frankforter T, Nich C, Szollosy S, Loya J, Brito L, Ribeiro M, Edmond S, Becker W, Martino S, Sofuoglu M, Heapy A. Efficacy of Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT) in Individuals With Chronic Pain and Opioid Use Disorder: Protocol for a Randomized Clinical Trial of a Digital Cognitive Behavioral Treatment. JMIR Research Protocols 2024, 13: e54342. PMID: 38506917, PMCID: PMC10993119, DOI: 10.2196/54342.Peer-Reviewed Original ResearchManagement of painRandomized clinical trialsClinical trialsCognitive behavioral treatmentBehavioral treatment
2023
Percentage of negative urine drug screens as a clinically meaningful endpoint for RCTs evaluating treatment for cocaine use
Loya J, Babuscio T, Nich C, Alessi S, Rash C, Kiluk B. Percentage of negative urine drug screens as a clinically meaningful endpoint for RCTs evaluating treatment for cocaine use. Drug And Alcohol Dependence 2023, 248: 109947. PMID: 37276806, PMCID: PMC10498479, DOI: 10.1016/j.drugalcdep.2023.109947.Peer-Reviewed Original ResearchConceptsUrine drug screensClinical trialsMeaningful endpointsCocaine useLong-term clinical benefitBetter long-term outcomesDrug screensPsychosocial functioningNegative urine drug screensLong-term outcomesRandomized clinical trialsFuture clinical trialsBetter psychosocial functioningClinical benefitPharmacological treatmentContinuous abstinenceTreatment periodTreatment respondersSustained abstinenceSubstance useTrialsTreatmentMeaningful thresholdPooled datasetAbstinence
2019
Sociodemographic and clinical outcome differences among individuals seeking treatment for cocaine use disorders. The intersection of gender and race
Miguel AQC, Jordan A, Kiluk BD, Nich C, Babuscio TA, Mari JJ, Carroll KM. Sociodemographic and clinical outcome differences among individuals seeking treatment for cocaine use disorders. The intersection of gender and race. Journal Of Substance Use And Addiction Treatment 2019, 106: 65-72. PMID: 31540613, PMCID: PMC6756185, DOI: 10.1016/j.jsat.2019.08.014.Peer-Reviewed Original ResearchConceptsCocaine use disorderTreatment trialsTreatment outcomesUse disordersWhite womenTreatment outcome indicatorsPoor overall outcomeClinical outcome differencesRandomized clinical trialsFocused treatment approachMore effective treatmentsDifferent psychosocial issuesSubstance use problemsSubgroup of individualsBaseline characteristicsPoor outcomePsychiatric comorbidityClinical trialsHigh prevalenceSociodemographic statusEffective treatmentOutcome differencesTreatment approachesPsychosocial issuesCocaine useDouble‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamine
2018
Culturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial.
Paris M, Silva M, Añez-Nava L, Jaramillo Y, Kiluk BD, Gordon MA, Nich C, Frankforter T, Devore K, Ball SA, Carroll KM. Culturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial. American Journal Of Public Health 2018, 108: 1535-1542. PMID: 30252519, PMCID: PMC6187780, DOI: 10.2105/ajph.2018.304571.Peer-Reviewed Original ResearchConceptsSubstance use disordersCognitive-behavioral treatmentUse disordersSubstance use outcomesClinical trialsWeb-based cognitive behavioral therapyCurrent substance use disorderUse outcomesRandomized clinical trialsStandard outpatient treatmentEvidence-based treatmentsCognitive behavioral therapyPrimary outcomeStandard treatmentOutpatient treatmentStandard outpatientTreatment completionHealth disparitiesBehavioral therapyBehavioral treatmentAddiction treatmentTreatment-seeking individualsGreater reductionTreatmentDisordersChange in DSM‐5 Alcohol Use Disorder Criteria Count and Severity Level as a Treatment Outcome Indicator: Results from a Randomized Trial
Kiluk BD, Frankforter TL, Cusumano M, Nich C, Carroll KM. Change in DSM‐5 Alcohol Use Disorder Criteria Count and Severity Level as a Treatment Outcome Indicator: Results from a Randomized Trial. Alcohol Clinical And Experimental Research 2018, 42: 1556-1563. PMID: 29870051, PMCID: PMC6281805, DOI: 10.1111/acer.13807.Peer-Reviewed Original ResearchAlcohol use disorderRandomized clinical trialsClinical trialsSeverity categoriesOutcome indicatorsDSM criteriaCurrent AUD diagnosisPotential outcome indicatorsTreatment outcome indicatorsWeekly outpatient treatmentMost clinical trialsStructured Clinical InterviewLinear mixed modelsTreatment end pointsCognitive behavioral therapy programCriterion countsMeaningful outcome indicatorsBehavioral therapy programAlcohol use outcomesOutpatient treatmentTrend-level significanceMain trialDiagnostic criteriaUse disordersBetter outcomes
2014
Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram
DeVito EE, Babuscio TA, Nich C, Ball SA, Carroll KM. Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram. Drug And Alcohol Dependence 2014, 145: 156-167. PMID: 25457739, PMCID: PMC4268325, DOI: 10.1016/j.drugalcdep.2014.10.007.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsClinical trialsClinical outcomesTreatment outcomesCocaine dependenceBehavioral therapyBehavioral treatment conditionsPoor treatment outcomesEvidence-based treatmentsGender differencesWidespread clinical implementationPoor outcomePharmacological treatmentMedication conditionAddiction pharmacotherapyCocaine useSecondary analysisBehavioral treatmentClinical implementationWomenCareful assessmentDisulfiramOutcomesTrialsMenAssessment concordance and predictive validity of self‐report and biological assay of cocaine use in treatment trials
Decker SE, Frankforter T, Babuscio T, Nich C, Ball SA, Carroll KM. Assessment concordance and predictive validity of self‐report and biological assay of cocaine use in treatment trials. American Journal On Addictions 2014, 23: 466-474. PMID: 24628970, PMCID: PMC4139466, DOI: 10.1111/j.1521-0391.2014.12132.x.Peer-Reviewed Original ResearchConceptsPredictive validityPsychosocial outcomesCocaine useSelf-report assessmentsSelf-report accuracyCocaine treatment trialSelf-reported dataPost-treatment pointSelf-reported cocaine useMethod variancePost-treatment outcomesTreatment trialsTreatment completionAssessment methodsUrinalysis resultsValidityRandomized clinical trials
2011
A Methodological Analysis of Randomized Clinical Trials of Computer-Assisted Therapies for Psychiatric Disorders: Toward Improved Standards for an Emerging Field
Kiluk BD, Sugarman DE, Nich C, Gibbons CJ, Martino S, Rounsaville BJ, Carroll KM. A Methodological Analysis of Randomized Clinical Trials of Computer-Assisted Therapies for Psychiatric Disorders: Toward Improved Standards for an Emerging Field. American Journal Of Psychiatry 2011, 168: 790-799. PMID: 21536689, PMCID: PMC3607199, DOI: 10.1176/appi.ajp.2011.10101443.Peer-Reviewed Original ResearchConceptsComputer-assisted therapyRandomized clinical trialsPsychiatric disordersClinical trialsMethodological qualityEvidence-based behavioral therapiesMethodological Quality IndexPotential adverse eventsEvidence-based therapiesAxis I DisordersAdult psychiatric disordersMethodological quality scoreEvidence-based interventionsAdverse eventsTreat principleRandomized trialsI disordersStudy qualityTreatment exposureTherapyBehavioral therapyCost-effective strategyDisordersTrialsCurrent standard
2010
Cognitive Function and Treatment Response in a Randomized Clinical Trial of Computer-Based Training in Cognitive-Behavioral Therapy
Carroll KM, Kiluk BD, Nich C, Babuscio TA, Brewer JA, Potenza MN, Ball SA, Martino S, Rounsaville BJ, Lejuez CW. Cognitive Function and Treatment Response in a Randomized Clinical Trial of Computer-Based Training in Cognitive-Behavioral Therapy. Substance Use & Misuse 2010, 46: 23-34. PMID: 21190403, PMCID: PMC3083447, DOI: 10.3109/10826084.2011.521069.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyCognitive functionComputer-assisted cognitive behavioral therapyComputer-assisted versionCognitive demandsCognitive functioningRisk takingPoor substanceSubstance usersHomework assignmentsHigh levelsClinical trialsSecondary analysisFunctioningRandomized clinical trialsParticipantsTreatment responseTakingTrainingSessionsSuch patients
2008
Enduring effects of a computer-assisted training program for cognitive behavioral therapy: A 6-month follow-up of CBT4CBT
Carroll KM, Ball SA, Martino S, Nich C, Babuscio TA, Rounsaville BJ. Enduring effects of a computer-assisted training program for cognitive behavioral therapy: A 6-month follow-up of CBT4CBT. Drug And Alcohol Dependence 2008, 100: 178-181. PMID: 19041197, PMCID: PMC2742309, DOI: 10.1016/j.drugalcdep.2008.09.015.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBehavioral therapyComputer-assisted training programSubstance dependenceComputer-based trainingSubstance use outcomesComputer-assisted versionDrug useEnduring effectCBT4CBTUse outcomesRandomized clinical trialsTreatment retentionDurability of effectTraining programOutpatient communityStudy treatmentStandard treatmentOutpatient treatmentClinical trialsTreatment conditionsParticipantsSignificant differencesTreatmentRegression analysisComputer-Assisted Delivery of Cognitive-Behavioral Therapy for Addiction: A Randomized Trial of CBT4CBT
Carroll KM, Ball SA, Martino S, Nich C, Babuscio TA, Nuro KF, Gordon MA, Portnoy GA, Rounsaville BJ. Computer-Assisted Delivery of Cognitive-Behavioral Therapy for Addiction: A Randomized Trial of CBT4CBT. American Journal Of Psychiatry 2008, 165: 881-888. PMID: 18450927, PMCID: PMC2562873, DOI: 10.1176/appi.ajp.2008.07111835.Peer-Reviewed Original Research
2004
Sex differences in cocaine-dependent individuals' response to disulfiram treatment
Nich C, McCance-Katz EF, Petrakis IL, Cubells JF, Rounsaville BJ, Carroll KM. Sex differences in cocaine-dependent individuals' response to disulfiram treatment. Addictive Behaviors 2004, 29: 1123-1128. PMID: 15236812, PMCID: PMC3680597, DOI: 10.1016/j.addbeh.2004.03.004.Peer-Reviewed Original ResearchConceptsDisulfiram treatmentDopamine-mediated responsesDrug-free urine specimensRandomized clinical trialsCocaine-dependent subjectsSex-based responsesDays of abstinenceSex differencesPrimary outcomeClinical trialsTreatment interactionUrine specimensBetter outcomesCocaine dependenceAlcohol useIntermediate outcomesDisulfiramSexOutcomesTreatmentSignificant sexIndividual responsesPossible mechanismResponseDifferential responseCost effectiveness of disulfiram Treating cocaine use in methadone-maintained patients
Jofre-Bonet M, Sindelar JL, Petrakis IL, Nich C, Frankforter T, Rounsaville BJ, Carroll KM. Cost effectiveness of disulfiram Treating cocaine use in methadone-maintained patients. Journal Of Substance Use And Addiction Treatment 2004, 26: 225-232. PMID: 15063917, PMCID: PMC3662046, DOI: 10.1016/s0740-5472(04)00004-2.Peer-Reviewed Original ResearchConceptsMethadone treatmentClinical trialsCocaine useDouble-blind clinical trialCocaine dependenceStandard methadone treatmentBlind clinical trialMethadone-maintained patientsRandomized clinical trialsOpioid-dependent subjectsMethadone-maintained opiate addictsStandard treatmentOutcome measuresOpioid addictsPromising treatmentOpiate addictsIncremental costDisulfiramAdditional treatmentNumber of daysTrialsTreatmentCost effectivenessEconomic evaluationAddicts
2002
‘Intention-to-treat’ meets ‘missing data’: implications of alternate strategies for analyzing clinical trials data
Nich C, Carroll KM. ‘Intention-to-treat’ meets ‘missing data’: implications of alternate strategies for analyzing clinical trials data. Drug And Alcohol Dependence 2002, 68: 121-130. PMID: 12234641, PMCID: PMC3651592, DOI: 10.1016/s0376-8716(02)00111-4.Peer-Reviewed Original ResearchConceptsEffectiveness of treatmentTreat analysisClinical trialsRandomized clinical trialsClinical trial dataStudy treatmentProtocol violationsTreat strategyTreatment retentionPoint of dropoutTime-varying covariatesTrial dataCocaine dependenceIntended durationParticipant dropoutRelative efficacyTrialsTreatmentMultiple analytic strategiesRetention outcomesDurationFull durationStrategy 1Analytic strategiesSubstantial levels
2001
FOCUS ON THERAPEUTIC ALLIANCE: THE PSYCHOMETRIC PROPERTIES OF SIX MEASURES ACROSS THREE TREATMENTS
Cecero J, Fenton L, Nich C, Frankforter T, Carroll K. FOCUS ON THERAPEUTIC ALLIANCE: THE PSYCHOMETRIC PROPERTIES OF SIX MEASURES ACROSS THREE TREATMENTS. Psychotherapy 2001, 38: 1-11. DOI: 10.1037/0033-3204.38.1.1.Peer-Reviewed Original Research
2000
A general system for evaluating therapist adherence and competence in psychotherapy research in the addictions
Carroll K, Nich C, Sifry R, Nuro K, Frankforter T, Ball S, Fenton L, Rounsaville B. A general system for evaluating therapist adherence and competence in psychotherapy research in the addictions. Drug And Alcohol Dependence 2000, 57: 225-238. PMID: 10661673, DOI: 10.1016/s0376-8716(99)00049-6.Peer-Reviewed Original ResearchConceptsTherapist adherenceRandomized clinical trialsSubstance use disordersDrug abuse treatmentYale AdherenceClinical trialsPharmacotherapy researchUse disordersBehavioral treatmentAbuse treatmentClinical researchAdherenceTreatmentComparison treatmentCompetence scoresExcellent reliabilityAddictionDiscriminant validityCompetence ScaleFactor structurePsychotherapy research
1997
Contribution of the Therapeutic Alliance to Outcome in Active Versus Control Psychotherapies
Carroll K, Nich C, Rounsaville B. Contribution of the Therapeutic Alliance to Outcome in Active Versus Control Psychotherapies. Journal Of Consulting And Clinical Psychology 1997, 65: 510-514. PMID: 9170775, DOI: 10.1037/0022-006x.65.3.510.Peer-Reviewed Original Research