2022
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19
Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K, Niklason L, Ko A, Montgomery R, Farhadian S, Iwasaki A, Shaw A, van Dijk D, Zhao H, Kleinstein S, Hafler D, Kaminski N, Dela Cruz C. Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19. Nature Communications 2022, 13: 440. PMID: 35064122, PMCID: PMC8782894, DOI: 10.1038/s41467-021-27716-4.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAgedAntibodies, Monoclonal, HumanizedCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedCOVID-19COVID-19 Drug TreatmentFemaleGene Expression ProfilingGene Expression RegulationHumansImmunity, InnateMaleReceptors, Antigen, B-CellReceptors, Antigen, T-CellRNA-SeqSARS-CoV-2Single-Cell AnalysisConceptsProgressive COVID-19B cell clonesSingle-cell analysisT cellsImmune responseMulti-omics single-cell analysisCOVID-19Cell clonesAdaptive immune interactionsSevere COVID-19Dynamic immune responsesGene expressionSARS-CoV-2 virusAdaptive immune systemSomatic hypermutation frequenciesCellular effectsProtein markersEffector CD8Immune signaturesProgressive diseaseHypermutation frequencyProgressive courseClassical monocytesClonesImmune interactions
2020
A satellite repeat-derived piRNA controls embryonic development of Aedes
Halbach R, Miesen P, Joosten J, Taşköprü E, Rondeel I, Pennings B, Vogels C, Merkling S, Koenraadt C, Lambrechts L, van Rij R. A satellite repeat-derived piRNA controls embryonic development of Aedes. Nature 2020, 580: 274-277. PMID: 32269344, PMCID: PMC7145458, DOI: 10.1038/s41586-020-2159-2.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsSatellite repeatsEmbryonic developmentGene expressionAbundant piwi-interacting RNAsLocal chromatin structureGlobal gene expressionTandem repeat elementsSequence-specific geneMosquito Aedes aegyptiPiRNA productionEukaryotic chromosomesChromatin structureEuchromatic regionsPiRNA sequencesMosquito biologyRepeat elementsDevelopmental arrestRepeatsDiverse classAedes aegyptiGenesTranscriptsCentral functionExpression