Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions
Fredericks CA, Drabant EM, Edge MD, Tillie JM, Hallmayer J, Ramel W, Kuo JR, Mackey S, Gross JJ, Dhabhar FS. Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions. Brain Behavior And Immunity 2009, 24: 350-357. PMID: 19883751, PMCID: PMC2826575, DOI: 10.1016/j.bbi.2009.10.014.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffectDNAFemaleGenotypeHumansInflammationInterleukin-10Interleukin-6Polymorphism, GeneticRestReverse Transcriptase Polymerase Chain ReactionSerotonin Plasma Membrane Transport ProteinsStress, PsychologicalYoung AdultConceptsPro-inflammatory biasTrier Social Stress TestLower anti-inflammatory cytokinesChronic pro-inflammatory stateIL-6/ILHigher IL-6/ILSerum IL-6Anti-inflammatory cytokinesPro-inflammatory stateHealthy young womenPro-inflammatory cytokinesSS individualsLife stressLow exposureStress testPromoter region polymorphismsIL-10IL-6Relevant biological effectsRecent life stressSocial Stress TestHealthy subjectsNeurobiological effectsClinical relevanceLL individuals