A case of progressive multifocal leukoencephalopathy in a lupus patient treated with belimumab
Fredericks C, Kvam K, Bear J, Crabtree G, Josephson. A case of progressive multifocal leukoencephalopathy in a lupus patient treated with belimumab. Lupus 2014, 23: 711-713. PMID: 24531080, DOI: 10.1177/0961203314524292.Peer-Reviewed Original ResearchConceptsProgressive multifocal leukoencephalopathySystemic lupus erythematosusMultifocal leukoencephalopathyAutoantibody-positive systemic lupus erythematosusDevelopment of PMLMild systemic lupus erythematosusTrials of belimumabProgressive neurologic declineFatal adverse effectsSoluble B lymphocyte stimulatorB lymphocyte stimulatorB cell maturationJCV PCRLupus patientsNeurologic declineSymptom onsetAutonomic symptomsLupus erythematosusT2 hyperintensityAutoimmune diseasesStandard treatmentBelimumabWhite matterEpisodic dystoniaCareful monitoring