2020
Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults
Trelle AN, Carr VA, Guerin SA, Thieu MK, Jayakumar M, Guo W, Nadiadwala A, Corso NK, Hunt MP, Litovsky CP, Tanner NJ, Deutsch GK, Bernstein JD, Harrison MB, Khazenzon AM, Jiang J, Sha SJ, Fredericks CA, Rutt BK, Mormino EC, Kerchner GA, Wagner AD. Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults. ELife 2020, 9: e55335. PMID: 32469308, PMCID: PMC7259949, DOI: 10.7554/elife.55335.Peer-Reviewed Original ResearchConceptsHippocampal pattern completionCortical reinstatementEpisodic memoryHippocampal activityOlder adultsPattern completionAge-related episodic memory declineTrial-unique associationsTrial-wise analysesEpisodic memory declineNormal older adultsEpisodic rememberingFMRI indicesMemory variabilityIndividual differencesUnique varianceAssociative retrievalMemory declineCortical mechanismsFMRI dataReinstatementMemoryAdultsRetrievalRemembering
2005
Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder
Blumberg HP, Fredericks C, Wang F, Kalmar JH, Spencer L, Papademetris X, Pittman B, Martin A, Peterson BS, Fulbright RK, Krystal JH. Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disorders 2005, 7: 570-576. PMID: 16403182, PMCID: PMC2291299, DOI: 10.1111/j.1399-5618.2005.00264.x.Peer-Reviewed Original ResearchConceptsAmygdala volumeBipolar disorderYoung adultsAmygdala volume abnormalitiesTotal brain volumeHigh-resolution magnetic resonancePreliminary evidenceSubjects longitudinal designPersistent abnormalitiesMixed-model statistical analysisBD IVolume abnormalitiesHealthy comparison participantsBrain volumeHealthy participantsAbnormalitiesAdultsAdolescentsComparison participantsAmygdalaDevelopmental epochsDisordersLongitudinal designParticipantsMagnetic resonance