2020
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
Zhao J, Lin King JV, Paulsen CE, Cheng Y, Julius D. Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature 2020, 585: 141-145. PMID: 32641835, PMCID: PMC7483980, DOI: 10.1038/s41586-020-2480-9.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceCalciumCysteineElectric ConductivityHumansIodoacetamideIon Channel GatingModels, MolecularMutationOximesTRPA1 Cation ChannelConceptsPrimary afferent nerve fibersTRP channel subtypesAfferent nerve fibersIon channel TRPA1Inflammatory painIrritant receptorsMetabotropic receptorsTRPA1 receptorsCytoplasmic second messengersNerve fibersChannel subtypesCalcium permeabilityCalcium modulationTRPA1 regulationTRPA1Environmental toxicantsFunctional couplingReceptorsPainItchExogenous agentsAttractive targetIrritantsActivationSecond messenger
2017
A Gate Hinge Controls the Epithelial Calcium Channel TRPV5
van der Wijst J, Leunissen EH, Blanchard MG, Venselaar H, Verkaart S, Paulsen CE, Bindels RJ, Hoenderop JG. A Gate Hinge Controls the Epithelial Calcium Channel TRPV5. Scientific Reports 2017, 7: 45489. PMID: 28374795, PMCID: PMC5379628, DOI: 10.1038/srep45489.Peer-Reviewed Original ResearchConceptsEpithelial calcium channel TRPV5Detailed molecular insightStructure-function analysisSite-directed mutagenesisChannel gating mechanismCalcium channel TRPV5TRP channel familyCarboxy terminusDepth structure-function analysisFunctional crosstalkGlycine residueHomology modelingMolecular insightsChannel familyCell deathPermeation pathwayChannel functionChannel TRPV5Increased cell deathNovel insightsIntracellular poresGating mechanismFlexible linkerPore regionTRPV5