2020
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
Zhao J, Lin King JV, Paulsen CE, Cheng Y, Julius D. Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature 2020, 585: 141-145. PMID: 32641835, PMCID: PMC7483980, DOI: 10.1038/s41586-020-2480-9.Peer-Reviewed Original ResearchConceptsPrimary afferent nerve fibersTRP channel subtypesAfferent nerve fibersIon channel TRPA1Inflammatory painIrritant receptorsMetabotropic receptorsTRPA1 receptorsCytoplasmic second messengersNerve fibersChannel subtypesCalcium permeabilityCalcium modulationTRPA1 regulationTRPA1Environmental toxicantsFunctional couplingReceptorsPainItchExogenous agentsAttractive targetIrritantsActivationSecond messenger
2009
Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches
Paulsen CE, Carroll KS. Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches. ACS Chemical Biology 2009, 5: 47-62. PMID: 19957967, PMCID: PMC4537063, DOI: 10.1021/cb900258z.Peer-Reviewed Original ResearchConceptsProtein functionReactive oxygen speciesIntracellular signal transductionCysteine switchRedox regulationSignal transductionCysteine oxidationCysteine residuesCurrent mechanistic insightsSecond messengerDiverse mechanismsMechanistic understandingMechanistic insightsOxygen speciesChemoselective oxidationNew therapeutic strategiesHydrogen peroxideRecent advancesOxidationTherapeutic strategiesTransductionSpeciesProteinMessengerResidues