2024
Disentangling negative and positive symptoms in schizophrenia and autism spectrum disorder
Corbera S, Wexler B, Bell M, Pittman B, Pelphrey K, Pearlson G, Assaf M. Disentangling negative and positive symptoms in schizophrenia and autism spectrum disorder. Schizophrenia Research 2024, 271: 1-8. PMID: 39002525, PMCID: PMC11384336, DOI: 10.1016/j.schres.2024.07.002.Peer-Reviewed Original ResearchAutism spectrum disorderPositive and Negative Syndrome ScaleAutism Diagnostic Observation Schedule-GenericExperiential negative symptomsPositive symptomsNegative symptomsExploratory factor analysisSpectrum disorderNegative Syndrome ScaleTarget negative symptomsSyndrome ScaleDiscriminant function analysisSZ relativesAssociated with quality of lifeSchizophreniaSocial skillsSocial functioningDiagnostic classificationAutismFactor analysisAssociated with qualityPredictor of diagnosisSymptomsDisordersQuality of life
2023
Aberrant hippocampus and amygdala morphology associated with cognitive deficits in schizophrenia
Peterson B, Kaur T, Sawardekar S, Colibazzi T, Hao X, Wexler B, Bansal R. Aberrant hippocampus and amygdala morphology associated with cognitive deficits in schizophrenia. Frontiers In Cellular Neuroscience 2023, 17: 1126577. PMID: 36909281, PMCID: PMC9996667, DOI: 10.3389/fncel.2023.1126577.Peer-Reviewed Original ResearchClinical symptomsHealthy controlsAnatomical abnormalitiesMemory deficitsPathogenesis of schizophreniaSeverity of symptomsEffects of schizophreniaHippocampal bodyAmygdala morphologyLimbic regionsPatientsHippocampusInward deformationCognitive deficitsBrain structuresHC participantsSchizophreniaAmygdalaSymptomsMemory performanceContinuum of severityAnatomical MRIPrimary disturbanceMemory scoresAbnormalities
2019
Measurement of executive functioning with the National Institute of Health Toolbox and the association to anxiety/depressive symptomatology in childhood/adolescence
Kavanaugh BC, Cancilliere MK, Fryc A, Tirrell E, Oliveira J, Oberman LM, Wexler BE, Carpenter LL, Spirito A. Measurement of executive functioning with the National Institute of Health Toolbox and the association to anxiety/depressive symptomatology in childhood/adolescence. Child Neuropsychology 2019, 26: 754-769. PMID: 31876232, PMCID: PMC10629577, DOI: 10.1080/09297049.2019.1708295.Peer-Reviewed Original ResearchConceptsAnxiety/depressive symptomatologyGlobal deficit scoreDepressive symptomatologyDetection of impairmentHealth ToolboxDepressive symptom varianceNational InstituteChildhood/adolescenceSelf-reported depressionComparable psychometric propertiesSymptom varianceEF symptomsDeficit scoresDepression diagnosisDepressive symptomsClinical diagnosisChild-reported anxietyClinical neuropsychological measuresImpairmentMeasures of EFSymptomatologyDepressionNeuropsychological measuresSymptomsParent report
2014
Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression
Morimoto SS, Wexler BE, Liu J, Hu W, Seirup J, Alexopoulos GS. Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression. Nature Communications 2014, 5: 4579. PMID: 25093396, PMCID: PMC4139707, DOI: 10.1038/ncomms5579.Peer-Reviewed Original ResearchConceptsExecutive dysfunctionExecutive functionGeriatric depressionComputerized cognitive remediationTreatment-resistant geriatric depressionHistorical controlsBrain network abnormalitiesCognitive remediationPoor clinical outcomeGold standard treatmentRemission of symptomsOlder adultsClinical outcomesDepression treatmentMajor depressionDepressive symptomsNetwork abnormalitiesEscitalopramDepressionSymptomsGreater improvementTreatmentDeficitsRemissionParticipants
2012
Empathy in electrodermal responsive and nonresponsive patients with schizophrenia
Ikezawa S, Corbera S, Liu J, Wexler BE. Empathy in electrodermal responsive and nonresponsive patients with schizophrenia. Schizophrenia Research 2012, 142: 71-76. PMID: 23058162, PMCID: PMC3502678, DOI: 10.1016/j.schres.2012.09.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAntipsychotic AgentsChlorpromazineElectroencephalographyEmpathyEvoked PotentialsFemaleGalvanic Skin ResponseHumansMaleMiddle AgedNeuropsychological TestsPersonality TestsPsychiatric Status Rating ScalesPsychotic DisordersRecognition, PsychologySchizophreniaSchizophrenic PsychologySocial BehaviorConceptsSkin conductance responsesEvent Related PotentialsSocial cognitionEmotion-evoking stimuliHealthy controlsPictures of peopleAssessment of symptomsERP responsesPersonal distressConductance responsesRelated potentialsNonresponsive patientsSchizophrenia patientsSCR frequencyCognitionPatientsSocial functionSocial integrationPotential markerSchizophreniaDistressPainPrognosisSubgroupsSymptoms
2002
Atypical Depression: Enhanced Right Hemispheric Dominance for Perceiving Emotional Chimeric Faces
Bruder GE, Stewart JW, McGrath PJ, Julie G, Wexler BE, Quitkin FM. Atypical Depression: Enhanced Right Hemispheric Dominance for Perceiving Emotional Chimeric Faces. Journal Of Psychopathology And Clinical Science 2002, 111: 446-454. PMID: 12150420, DOI: 10.1037/0021-843x.111.3.446.Peer-Reviewed Original ResearchConceptsMajor depressive disorderAtypical depressionTypical depressionRight hemispheric dominanceNeurophysiologic studiesDepressive disorderHealthy controlsVegetative symptomsPatientsDistinct subtypesDiagnostic distinctionHemisphere biasHemispheric dominanceDepressionDysthymiaRight hemisphere biasFurther evidenceFace testHemispatial biasPhysical anhedoniaSymptomsSubtypesControl
1996
Affective reactivity of cognitive functioning and family history in schizophrenia
Docherty N, Grosh E, Wexler B. Affective reactivity of cognitive functioning and family history in schizophrenia. Biological Psychiatry 1996, 39: 59-64. PMID: 8719127, DOI: 10.1016/0006-3223(95)00102-6.Peer-Reviewed Original ResearchConceptsAffective reactivityNegative affectCognitive functioningRight ear advantageDichotic listening testThought disorder symptomsNegative stimuliNegative taskNeutral taskDisorder symptomsCognitive symptomsThought disorderFamily psychiatric historyOutpatient sampleListening testsAffectSchizophreniaFunctioningTaskSchizophrenic inpatientsPsychiatric historyDisordersStimuliSymptomsFindings
1995
Behavioral laterality in individuals with Gilles de la Tourette's syndrome and basal ganglia alterations: A preliminary report
Yazgan M, Peterson B, Wexler B, Leckman J. Behavioral laterality in individuals with Gilles de la Tourette's syndrome and basal ganglia alterations: A preliminary report. Biological Psychiatry 1995, 38: 386-390. PMID: 8547458, DOI: 10.1016/0006-3223(94)00302-j.Peer-Reviewed Original ResearchConceptsGTS patientsTourette syndromeIntact basal ganglia functionGilles de la Tourette's syndromeGTS subjectsAdult GTS patientsBasal ganglia alterationsBasal ganglia functionLa Tourette's syndromePrevious MRI studiesNeuropsychological measuresFunctional asymmetryGanglia functionTic symptomsNormal controlsMRI studiesSyndromePreliminary reportPatientsNeuropsychological tasksFunctional significanceSubjectsBehavioral lateralitySymptomsAbnormalities
1994
Affective Reactivity of Language in Stable Schizophrenic Outpatients and Their Parents
DOCHERTY N, SLEDGE W, WEXLER B. Affective Reactivity of Language in Stable Schizophrenic Outpatients and Their Parents. The Journal Of Nervous And Mental Disease 1994, 182: 313-318. PMID: 8201302, DOI: 10.1097/00005053-199406000-00001.Peer-Reviewed Original Research
1991
Cerebral laterality, symptoms, and diagnosis in psychotic patients
Wexler B, Giller E, Southwick S. Cerebral laterality, symptoms, and diagnosis in psychotic patients. Biological Psychiatry 1991, 29: 103-116. PMID: 1995082, DOI: 10.1016/0006-3223(91)90039-o.Peer-Reviewed Original ResearchConceptsRight ear advantageLower right-ear advantagesManic patientsPositive symptomsNegative symptomsCerebral lateralitySubset of patientsDisease-related decreaseWord TestSchizoaffective patientsSymptomatic inpatientsDepressed patientsHealthy controlsSymptom remissionSchizophrenic patientsMood disturbancePatientsMore symptomsPsychotic patientsSymptomsDichotic word testLeft hemisphereEar advantageThought disorderSimilar changes