2024
Disentangling negative and positive symptoms in schizophrenia and autism spectrum disorder
Corbera S, Wexler B, Bell M, Pittman B, Pelphrey K, Pearlson G, Assaf M. Disentangling negative and positive symptoms in schizophrenia and autism spectrum disorder. Schizophrenia Research 2024, 271: 1-8. PMID: 39002525, PMCID: PMC11384336, DOI: 10.1016/j.schres.2024.07.002.Peer-Reviewed Original ResearchAutism spectrum disorderPositive and Negative Syndrome ScaleAutism Diagnostic Observation Schedule-GenericExperiential negative symptomsPositive symptomsNegative symptomsExploratory factor analysisSpectrum disorderNegative Syndrome ScaleTarget negative symptomsSyndrome ScaleDiscriminant function analysisSZ relativesAssociated with quality of lifeSchizophreniaSocial skillsSocial functioningDiagnostic classificationAutismFactor analysisAssociated with qualityPredictor of diagnosisSymptomsDisordersQuality of life
2023
Cognitive training for children with ADHD: composite cognitive score outcome in a randomized controlled trial
Bikic A, Dalsgaard S, Pittman B, Leckman J, Wexler B. Cognitive training for children with ADHD: composite cognitive score outcome in a randomized controlled trial. Nordic Journal Of Psychiatry 2023, 78: 87-91. PMID: 37905332, DOI: 10.1080/08039488.2023.2270954.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderCognitive trainingDeficit/hyperactivity disorderComposite cognition scoreSessions of trainingCognitive functioningHyperactivity disorderCognitive improvementCognition scoresTraining sessionsMixed resultsFrequency of trainingTrainingChildrenSessionsIntervention groupCognitionInterventionFunctioningPost Hoc AnalysisScore outcomesControl groupPrevious studiesDisordersOutcomes
2018
F254. Social Processing Subtyping and Functional Neural Architecture Across Autism Spectrum Disorder, Schizophrenia and Non-Clinical Sample
Assaf M, Corbera S, Rabany L, Brocke S, Pitman B, Johannesen J, Bell M, Calhoun V, Wexler B, Pearlson G. F254. Social Processing Subtyping and Functional Neural Architecture Across Autism Spectrum Disorder, Schizophrenia and Non-Clinical Sample. Biological Psychiatry 2018, 83: s337-s338. DOI: 10.1016/j.biopsych.2018.02.868.Peer-Reviewed Original Research
2010
Predictors of Participation in Community Outpatient Psychosocial Rehabilitation in Schizophrenia
Kurtz MM, Rose J, Wexler BE. Predictors of Participation in Community Outpatient Psychosocial Rehabilitation in Schizophrenia. Community Mental Health Journal 2010, 47: 622-627. PMID: 20676766, PMCID: PMC3046324, DOI: 10.1007/s10597-010-9343-z.Peer-Reviewed Original ResearchConceptsLower verbal fluency scoresVerbal fluency scoresSchizoaffective disorderPsychosocial rehabilitation programsVerbal learningVerbal abilityNeurocognitive factorsVisual vigilanceVerbal fluencyFluency scoresNeurocognitive assessmentDSM-IV schizophreniaSymptom measuresPsychosocial rehabilitationPredictors of participationDemographic variablesSchizophreniaFinal multivariate modelRehabilitation programGreater likelihoodRace/ethnicityStudy entryFluencyDisordersMeasures
2005
Neurocognitive enhancement therapy with work therapy: Productivity outcomes at 6- and 12-month follow-ups
Bell MD, Bryson GJ, Greig TC, Fiszdon JM, Wexler BE. Neurocognitive enhancement therapy with work therapy: Productivity outcomes at 6- and 12-month follow-ups. The Journal Of Rehabilitation Research And Development 2005, 42: 829. PMID: 16680620, DOI: 10.1682/jrrd.2005.03.0061.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive Behavioral TherapyCombined Modality TherapyFollow-Up StudiesHumansMiddle AgedNeuropsychological TestsOdds RatioPatient ComplianceProbabilityPsychiatric Status Rating ScalesPsychotic DisordersRehabilitation, VocationalRisk AssessmentSchizophreniaTask Performance and AnalysisTime FactorsTreatment OutcomeConceptsNeurocognitive enhancement therapyWork therapyCognitive trainingEnhancement therapyComputerized cognitive trainingExecutive functionWork outcomesCommunity mental health centerDiagnosis of schizophreniaMental health centersMental hygiene clinicSchizoaffective disorderRandom effects analysisNet trainingProductivity outcomesTrainingRehabilitation programSchizophreniaMore hoursMemoryPresent studyDisordersOutcomesEffect analysisFindings
2003
Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation
Donegan NH, Sanislow CA, Blumberg HP, Fulbright RK, Lacadie C, Skudlarski P, Gore JC, Olson IR, McGlashan TH, Wexler BE. Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation. Biological Psychiatry 2003, 54: 1284-1293. PMID: 14643096, DOI: 10.1016/s0006-3223(03)00636-x.Peer-Reviewed Original ResearchConceptsNormal control subjectsBorderline personality disorderControl subjectsBorderline patientsAmygdala hyperreactivityBPD patientsPersonality disorderEmotional dysregulationDisorders of moodFunctional magnetic resonance imagingMagnetic resonance imagingClinical research teamPatientsResonance imagingPsychiatry departmentDSM-IVAmygdala reactivityAmygdala activationDisordersNeural responsesHyperreactivityDysregulationActivation levelsSubjectsRobust differences
1996
Affective reactivity of cognitive functioning and family history in schizophrenia
Docherty N, Grosh E, Wexler B. Affective reactivity of cognitive functioning and family history in schizophrenia. Biological Psychiatry 1996, 39: 59-64. PMID: 8719127, DOI: 10.1016/0006-3223(95)00102-6.Peer-Reviewed Original ResearchConceptsAffective reactivityNegative affectCognitive functioningRight ear advantageDichotic listening testThought disorder symptomsNegative stimuliNegative taskNeutral taskDisorder symptomsCognitive symptomsThought disorderFamily psychiatric historyOutpatient sampleListening testsAffectSchizophreniaFunctioningTaskSchizophrenic inpatientsPsychiatric historyDisordersStimuliSymptomsFindings
1991
Cerebral laterality, perception of emotion, and treatment response in obsessive-compulsive disorder
Wexler B, Goodman W. Cerebral laterality, perception of emotion, and treatment response in obsessive-compulsive disorder. Biological Psychiatry 1991, 29: 900-908. PMID: 2049488, DOI: 10.1016/0006-3223(91)90056-r.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderEmotion-related wordsNeutral wordsCerebral lateralityLower right-ear advantagesPerception of emotionPositive emotional valenceRight ear advantageDichotic listening testEmotional valenceStimulus pairsOCD patientsListening testsWordsHealthy controlsDepressed patientsSerotonin reuptake inhibitorsLateralityEmotionsDisordersReuptake inhibitorsSevere illnessTreatment responseValencePatients
1989
Possible Subtypes of Affective Disorder Suggested by Differences in Cerebral Laterality and Testosterone: A Preliminary Report
Wexler B, Mason J, Giller E. Possible Subtypes of Affective Disorder Suggested by Differences in Cerebral Laterality and Testosterone: A Preliminary Report. JAMA Psychiatry 1989, 46: 429-433. PMID: 2712661, DOI: 10.1001/archpsyc.1989.01810050043007.Peer-Reviewed Original ResearchConceptsSerum testosterone levelsDichotic listening testAffective disordersTestosterone levelsMean serum testosterone levelCerebral lateralityTime of admissionPathophysiological heterogeneityDiagnostic groupsSymptom severityPreliminary reportPossible subtypesHemisphere functionDisordersSubgroupsLateralityMeaningful subgroupsPositive correlationNegative correlationGroupHospitalizationPatientsAdmissionPathogenesesTestosterone