2017
Value of a flow cytometry cross‐match in the setting of a negative complement‐dependent cytotoxicity cross‐match in heart transplant recipients
Keeshan BC, O'Connor MJ, Lin KY, Monos D, Lind C, Mascio CE, Rame JE, Spray TL, Shaddy RE, Rossano JW. Value of a flow cytometry cross‐match in the setting of a negative complement‐dependent cytotoxicity cross‐match in heart transplant recipients. Clinical Transplantation 2017, 31 PMID: 28766759, DOI: 10.1111/ctr.13064.Peer-Reviewed Original ResearchConceptsHeart transplant recipientsGraft survivalPositive FCXMHeart transplantationTransplant recipientsT cellsB cellsNegative complement-dependent cytotoxicityCox proportional hazard modelingDecreased graft survivalOrgan Sharing databaseHLA-specific antibodiesKaplan-Meier analysisCross-match resultsProportional hazard modelingDifferent patient cohortsComplement-dependent cytotoxicityXM patientsGraft failureSharing databaseUnited NetworkPatient cohortInclusion criteriaCross matchClinical relevance
2015
Changes in the methodology of pre‐heart transplant human leukocyte antibody assessment: an analysis of the United Network for Organ Sharing database
O'Connor MJ, Keeshan BC, Lin KY, Monos D, Lind C, Paridon SM, Mascio CE, Shaddy RE, Rossano JW. Changes in the methodology of pre‐heart transplant human leukocyte antibody assessment: an analysis of the United Network for Organ Sharing database. Clinical Transplantation 2015, 29: 842-850. PMID: 26172275, DOI: 10.1111/ctr.12590.Peer-Reviewed Original ResearchConceptsPanel reactive antibodyHuman leukocyte antibodiesOrgan Sharing databaseHeart transplantationReactive antibodiesGraft lossLeukocyte antibodiesSharing databaseUnited NetworkAntibody assessmentFlow cytometryClass IPre-transplant patientsUnderwent heart transplantationTime of transplantationPrimary outcome measureFlow cytometric assessmentGraft survivalMultivariable analysisOutcome measuresTransplantationCytometric assessmentPatientsStudy periodAntibodies
2013
Impact of congenital heart disease on outcomes of pediatric heart‐lung transplantation
Keeshan BC, Goldfarb SB, Lin KY, Kreindler JL, Kaufman BD, Gaynor JW, Shaddy RE, Rossano JW. Impact of congenital heart disease on outcomes of pediatric heart‐lung transplantation. Pediatric Transplantation 2013, 18: 204-210. PMID: 24373099, DOI: 10.1111/petr.12208.Peer-Reviewed Original ResearchConceptsPediatric heart-lung transplantationPretransplant mechanical ventilationWorse graft survivalHeart-lung transplantationComplex patient populationCongenital heart diseaseDiagnosis of CHDPretransplant PRATransplant eraGraft survivalPreoperative factorsUNOS databaseGraft failureMechanical ventilationMultivariable analysisWorse prognosisPatient survivalPoor outcomeCardiopulmonary diseasePatient populationAlternative therapiesHeart diseaseRetrospective analysisYounger ageCHD