2023
Platelet response to influenza vaccination reflects effects of aging
Konstorum A, Mohanty S, Zhao Y, Melillo A, Vander Wyk B, Nelson A, Tsang S, Blevins T, Belshe R, Chawla D, Rondina M, Gill T, Montgomery R, Allore H, Kleinstein S, Shaw A. Platelet response to influenza vaccination reflects effects of aging. Aging Cell 2023, 22: e13749. PMID: 36656789, PMCID: PMC9924941, DOI: 10.1111/acel.13749.Peer-Reviewed Original ResearchConceptsCommunity-dwelling older adultsPlatelet activationOlder adultsInfluenza vaccinationAge-associated chronic inflammationInfluence platelet functionRNA expressionPro-inflammatory diseasesAge-associated increasePlatelet activation pathwaysAge-associated differencesActivation pathwayPlatelet transcriptomeGeriatric conditionsChronic inflammationImmune responsePlatelet functionPlatelet responseSNF residentsVaccinationActivation responseYoung individualsProtein levelsAdultsYounger participants
2022
Population-Based Estimates of 1-Year Mortality After Major Surgery Among Community-Living Older US Adults
Gill TM, Vander Wyk B, Leo-Summers L, Murphy TE, Becher RD. Population-Based Estimates of 1-Year Mortality After Major Surgery Among Community-Living Older US Adults. JAMA Surgery 2022, 157: e225155. PMID: 36260323, PMCID: PMC9582971, DOI: 10.1001/jamasurg.2022.5155.Peer-Reviewed Original ResearchConceptsPopulation-based estimatesMajor surgeryMean survival timeOlder US adultsProbable dementiaUS adultsSurvival timeSex-adjusted hazard ratioProspective longitudinal cohort studyCommunity-living older adultsLongitudinal cohort studyPotential prognostic valueService Medicare beneficiariesNon-Hispanic blacksNon-Hispanic whitesAging Trends StudyGeriatric characteristicsCohort studyGeriatric surgeryHazard ratioNonelective surgeryElective surgeryGeriatric conditionsPrognostic valueMean ageFactors associated with retention on medications for opioid use disorder among a cohort of adults seeking treatment in the community
Biondi BE, Vander Wyk B, Schlossberg EF, Shaw A, Springer SA. Factors associated with retention on medications for opioid use disorder among a cohort of adults seeking treatment in the community. Addiction Science & Clinical Practice 2022, 17: 15. PMID: 35255967, PMCID: PMC8899775, DOI: 10.1186/s13722-022-00299-1.Peer-Reviewed Original ResearchConceptsOpioid use disorderHigher pain interferenceMOUD retentionPain interferenceUse disordersOngoing prospective cohort studySevere opioid use disorderProspective cohort studyMultivariable logistic regressionCohort of adultsMethadone doseAnalgesic effectBuprenorphine doseCohort studyOpioid useResultsA totalHigher oddsMOUDAdjusted modelHigh doseLogistic regressionBuprenorphineMethadoneDoseDiscontinuation
2020
Single cell immune profiling of dengue virus patients reveals intact immune responses to Zika virus with enrichment of innate immune signatures
Zhao Y, Amodio M, Vander Wyk B, Gerritsen B, Kumar MM, van Dijk D, Moon K, Wang X, Malawista A, Richards MM, Cahill ME, Desai A, Sivadasan J, Venkataswamy MM, Ravi V, Fikrig E, Kumar P, Kleinstein SH, Krishnaswamy S, Montgomery RR. Single cell immune profiling of dengue virus patients reveals intact immune responses to Zika virus with enrichment of innate immune signatures. PLOS Neglected Tropical Diseases 2020, 14: e0008112. PMID: 32150565, PMCID: PMC7082063, DOI: 10.1371/journal.pntd.0008112.Peer-Reviewed Original ResearchConceptsZika virusCell subsetsDengue virusConcurrent dengue infectionInnate cell responsesInnate immune signaturesVirus-infected individualsDivergent clinical outcomesMosquito-borne human pathogenIntact immune responsePre-existing infectionInnate cell typesSingle-cell immune profilingPublic health importanceCell typesImmune signaturesVirus patientsWest Nile virusAcute patientsClinical outcomesImmune profilingDengue infectionImmune statusFunctional statusImmune cells
2013
Social, reward, and attention brain networks are involved when online bids for joint attention are met with congruent versus incongruent responses
Gordon I, Eilbott JA, Feldman R, Pelphrey KA, Vander Wyk B. Social, reward, and attention brain networks are involved when online bids for joint attention are met with congruent versus incongruent responses. Social Neuroscience 2013, 8: 544-554. PMID: 24044427, DOI: 10.1080/17470919.2013.832374.Peer-Reviewed Original ResearchConceptsJoint attentionTemporoparietal junctionIncongruent responsesFMRI paradigmFunctional magnetic resonance imaging (fMRI) researchDorsal anterior cingulate cortexNaturalistic fMRI paradigmsHuman social functioningImpact of congruencySocial responsesRight temporoparietal junctionEye gaze patternsRight fusiform gyrusPosterior parietal cortexMagnetic resonance imaging researchAnterior cingulate cortexSocial neuroscienceIncongruent trialsAttention circuitsFusiform gyrusCongruent responsesNeural activationBrain networksRight amygdalaSocial functioningBrain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings
Zebardast N, Crowley MJ, Bloch MH, Mayes LC, Vander Wyk BV, Leckman JF, Pelphrey KA, Swain JE. Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings. Psychiatry Research 2013, 214: 33-41. PMID: 23916249, PMCID: PMC3932431, DOI: 10.1016/j.pscychresns.2013.05.009.Peer-Reviewed Original ResearchConceptsTourette syndromeFunctional magnetic resonance imagingHealthy subjectsTic severityWhole-brain functional magnetic resonance imagingYale Global Tic Severity ScaleTactile startle responseCase-control study designTic Severity ScaleCortical-striatal circuitsBrain activityMagnetic resonance imagingMultiple brain regionsLeft middle frontal gyrusMiddle frontal gyrusDegree of PPIPulse-alone stimuliBlock-design fMRI paradigmTic symptomsNeuropathological dataHealthy controlsPrepulse inhibitionDevelopmental neuropsychiatric disordersSensorimotor gatingLeft caudate
2012
Action representation in the superior temporal sulcus in children and adults: An fMRI study
Vander Wyk B, Voos A, Pelphrey KA. Action representation in the superior temporal sulcus in children and adults: An fMRI study. Developmental Cognitive Neuroscience 2012, 2: 409-416. PMID: 22727762, PMCID: PMC3431200, DOI: 10.1016/j.dcn.2012.04.004.Peer-Reviewed Original ResearchConceptsSuperior temporal sulcusFunctional magnetic resonance imaging paradigmCongruent trialsTemporal sulcusPosterior superior temporal sulcusIncongruent actionsBiological motionSTS regionFMRI studyAction representationNegative regardImaging paradigmOrder informationHigher-order informationDevelopmental changesOlder childrenChildrenSulcusAdultsTrialsCongruencyRepresentationCongruentPerceptionObjects
2011
Brain Mechanisms for Processing Direct and Averted Gaze in Individuals with Autism
Pitskel NB, Bolling DZ, Hudac CM, Lantz SD, Minshew NJ, Vander Wyk BC, Pelphrey KA. Brain Mechanisms for Processing Direct and Averted Gaze in Individuals with Autism. Journal Of Autism And Developmental Disorders 2011, 41: 1686-1693. PMID: 21484518, PMCID: PMC3337548, DOI: 10.1007/s10803-011-1197-x.Peer-Reviewed Original ResearchConceptsAverted gazeBrain mechanismsCritical social cueRight temporoparietal junctionLateral occipital cortexDorsolateral prefrontal cortexRight anterior insulaSocial processingTemporoparietal junctionSocial cuesComparison participantsAnterior insulaFMRI studySocial deficitsSocial scenariosGaze directionPrefrontal cortexCondition interactionAutismSocial encountersDifferential processingInitial evidenceOccipital cortexGazeSignificant group
2010
Cortical integration of audio–visual speech and non-speech stimuli
Vander Wyk B, Ramsay GJ, Hudac CM, Jones W, Lin D, Klin A, Lee SM, Pelphrey KA. Cortical integration of audio–visual speech and non-speech stimuli. Brain And Cognition 2010, 74: 97-106. PMID: 20709442, PMCID: PMC3869029, DOI: 10.1016/j.bandc.2010.07.002.Peer-Reviewed Original ResearchConceptsLateral occipital cortexUni-modal stimuliNon-speech stimuliAudio-visual speechVisual stimuliOccipital cortexRight inferior frontal gyrusAudio-visual pairingsSimilar auditory stimuliMulti-modal stimuliAudio-visual processingSuperior temporal sulcusInferior frontal gyrusMiddle temporal regionsMiddle temporal gyrusDifferent cortical networksNeural basisTemporal sulcusAuditory stimuliFusiform gyrusFrontal gyrusTemporal gyrusCortical networksCortical integrationTemporal regionsBrain mechanisms for representing what another person sees
Heyda RD, Green SR, Vander Wyk B, Morris JP, Pelphrey KA. Brain mechanisms for representing what another person sees. NeuroImage 2010, 50: 693-700. PMID: 20056152, PMCID: PMC2824003, DOI: 10.1016/j.neuroimage.2009.12.101.Peer-Reviewed Original ResearchConceptsExtrastriate body areaParahippocampal place areaFunctional magnetic resonance imagingSocial cognitionVisual attentionDual-role hypothesisAttribution hypothesisPerson's visual attentionWhole-brain analysisSocial brainStimulus categoriesBrain mechanismsPlace areaVisible stimuliVisual regionsSame stimuliBrain regionsInterest analysisCognitionStimuliParticipants' viewsSpecific categoriesMagnetic resonance imagingExtrastriateHypothesis
2009
Individual Differences in Personality Predict How People Look at Faces
Perlman SB, Morris JP, Vander Wyk B, Green SR, Doyle JL, Pelphrey KA. Individual Differences in Personality Predict How People Look at Faces. PLOS ONE 2009, 4: e5952. PMID: 19543398, PMCID: PMC2695783, DOI: 10.1371/journal.pone.0005952.Peer-Reviewed Original ResearchConceptsPersonality traitsIndividual differencesSocial behaviorEmotional facial expressionsPrevious behavioral researchSpecific personality traitsFearful facesSocial cognitionEmotional informationVisual scanpathsNegative emotionalityAmygdala reactivityRelevant stimuliFacial expressionsEye gazeInterpersonal interactionsEye contactEye trackingBehavioral linkBehavioral researchPersonalityNeuroticismBrain functionSerotonin transporter geneContextual determinantsAction Understanding in the Superior Temporal Sulcus Region
Vander Wyk BC, Hudac CM, Carter EJ, Sobel DM, Pelphrey KA. Action Understanding in the Superior Temporal Sulcus Region. Psychological Science 2009, 20: 771-777. PMID: 19422619, PMCID: PMC2849148, DOI: 10.1111/j.1467-9280.2009.02359.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionBrain MappingChoice BehaviorColor PerceptionConcept FormationDominance, CerebralEmotionsFemaleHumansImage Processing, Computer-AssistedIntentionMagnetic Resonance ImagingMaleMotion PerceptionOxygenPattern Recognition, VisualPersonal Construct TheoryPsychomotor PerformanceSocial PerceptionTemporal LobeYoung AdultConceptsSuperior temporal sulcus regionEmotional expressionSTS regionPosterior superior temporal sulcus regionSulcus regionFunctional magnetic resonancePosterior STSAction understandingBiological motionEmotional contextNegative emotionsNegative regardPositive regardPerson's motionSocial actCongruentParticipantsIntentionEmotionsObjectsCongruencyPerceptionActionActressMagnetic resonance