2015
Trait-level temporal lobe hypoactivation to social exclusion in unaffected siblings of children and adolescents with autism spectrum disorders
Bolling DZ, Pelphrey KA, Vander Wyk B. Trait-level temporal lobe hypoactivation to social exclusion in unaffected siblings of children and adolescents with autism spectrum disorders. Developmental Cognitive Neuroscience 2015, 13: 75-83. PMID: 26011751, PMCID: PMC4470300, DOI: 10.1016/j.dcn.2015.04.007.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderPosterior superior temporal sulcusUnaffected siblingsAtypical neural processingSocial exclusionFunctional magnetic resonance imagingSuperior temporal sulcusAbnormal neural responsesAnterior temporoparietal junctionAnterior cingulate cortexEmotion processingTemporoparietal junctionNegative affectTemporal sulcusNeural processingBrain responsesNeural endophenotypesNeural responsesNeural activationCingulate cortexNeural circuitrySocial experienceASD probandsPowerful feelings
2013
Equivalent neural responses in children and adolescents with and without autism during judgments of affect
Vander Wyk B, Hoffman F, Pelphrey KA. Equivalent neural responses in children and adolescents with and without autism during judgments of affect. Developmental Cognitive Neuroscience 2013, 8: 121-130. PMID: 24016745, PMCID: PMC3931746, DOI: 10.1016/j.dcn.2013.08.001.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCognitive loadNeural activationGreater cognitive loadFunction of taskFunctional connectivity analysisLonger stimulus durationsEmotion processingFMRI taskCondition contrastsNeural responsesSpectrum disorderStimulus durationBehavior measuresConnectivity analysisGroup differencesPrior researchPrevious researchEmotionsTaskChildrenValence levelsIQAutismIndividuals
2012
Neural Mechanisms of Improvements in Social Motivation After Pivotal Response Treatment: Two Case Studies
Voos AC, Pelphrey KA, Tirrell J, Bolling DZ, Wyk B, Kaiser MD, McPartland JC, Volkmar FR, Ventola P. Neural Mechanisms of Improvements in Social Motivation After Pivotal Response Treatment: Two Case Studies. Journal Of Autism And Developmental Disorders 2012, 43: 1-10. PMID: 23104615, PMCID: PMC4999079, DOI: 10.1007/s10803-012-1683-9.Peer-Reviewed Original ResearchConceptsPivotal Response TreatmentAutism spectrum disorderSocial stimuliResponse treatmentFunctional magnetic resonance imagingYoung childrenNeural correlatesSocial motivationSocial skillsSocial perceptionNeural mechanismsNeural responsesBehavioral measuresSpectrum disorderSocial communicationBehavioral treatmentEye trackingNeural systemsAdaptive behaviorBrain regionsBaseline measuresStriking gainsStimuliChildrenPositive effect
2011
Differential brain responses to social exclusion by one's own versus opposite-gender peers
Bolling DZ, Pelphrey KA, Vander Wyk B. Differential brain responses to social exclusion by one's own versus opposite-gender peers. Social Neuroscience 2011, 7: 331-346. PMID: 21981758, PMCID: PMC4520218, DOI: 10.1080/17470919.2011.623181.Peer-Reviewed Original ResearchConceptsCortex activationVentrolateral prefrontal cortex activationImplicit gender attitudesAnterior cingulate cortex activationBall-tossing gameOpposite-gender peersDifferential brain responsesVentrolateral prefrontal cortexSelf-reported distressPrefrontal cortex activationSame-gender peersFunctional magnetic resonanceSocial exclusionSocial cognitionIndividual differencesPsychological threatBrain responsesNeural responsesPeer relationsPrefrontal cortexEmotional benefitsOwn genderOpposite genderGender attitudesCurrent studyEnhanced neural responses to rule violation in children with autism: A comparison to social exclusion
Bolling DZ, Pitskel NB, Deen B, Crowley MJ, McPartland JC, Kaiser MD, Vander Wyk BC, Wu J, Mayes LC, Pelphrey KA. Enhanced neural responses to rule violation in children with autism: A comparison to social exclusion. Developmental Cognitive Neuroscience 2011, 1: 280-294. PMID: 21743819, PMCID: PMC3129780, DOI: 10.1016/j.dcn.2011.02.002.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderFunctional magnetic resonance imagingRight insulaVentral anterior cingulate cortexSocial exclusionAtypical neural networksRule violationsBall-tossing gameDorsal prefrontal cortexRepetitive behavior patternsAnterior cingulate cortexASD groupNeural correlatesBrain responsesSocial impairmentNeural responsesCharacteristic deficitsSpectrum disorderNeurobiological differencesPrefrontal cortexCingulate cortexFunctional connectivityComparable gamesInsulaGroup differences