2021
Mapping brain-behavior space relationships along the psychosis spectrum
Ji JL, Helmer M, Fonteneau C, Burt JB, Tamayo Z, Demšar J, Adkinson BD, Savić A, Preller KH, Moujaes F, Vollenweider FX, Martin WJ, Repovš G, Cho YT, Pittenger C, Murray JD, Anticevic A. Mapping brain-behavior space relationships along the psychosis spectrum. ELife 2021, 10: e66968. PMID: 34313219, PMCID: PMC8315806, DOI: 10.7554/elife.66968.Peer-Reviewed Original ResearchConceptsPsychosis spectrum disordersEffective patient-specific therapiesPSD patientsAllen Human Brain AtlasReceptor manipulationPatient-specific therapiesPsychiatric disordersBiomarker endpointsCognitive deficitsIndividualized predictionHuman Brain AtlasMolecular targetsActionable pathSymptom variationPsychosis spectrumPsychopathology symptomsBrain mapsCurrent sample sizeDisordersBrain atlasWhite matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis
Di Biase MA, Cetin-Karayumak S, Lyall AE, Zalesky A, Cho KIK, Zhang F, Kubicki M, Rathi Y, Lyons MG, Bouix S, Billah T, Anticevic A, Schleifer C, Adkinson BD, Ji JL, Tamayo Z, Addington J, Bearden CE, Cornblatt BA, Keshavan MS, Mathalon DH, McGlashan TH, Perkins DO, Cadenhead KS, Tsuang MT, Woods SW, Stone WS, Shenton ME, Cannon TD, Pasternak O. White matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis. Molecular Psychiatry 2021, 26: 6833-6844. PMID: 34024906, PMCID: PMC8611104, DOI: 10.1038/s41380-021-01128-8.Peer-Reviewed Original ResearchConceptsClinical high riskWhite matter changesWhite matter microstructureHigh riskMatter changesCHR individualsAge-related white matter changesNorth American Prodrome Longitudinal StudyEmergence of psychosisWhite matter abnormalitiesYears of ageImpact of ageIllness onsetExtracellular free waterHealthy controlsLongitudinal cohortCHR subjectsMagnetic resonance imaging dataProspective analysisRegional fatLinear mixed effects modelsHigh fatPsychosisFractional anisotropyBaseline measures
2018
Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor
Preller KH, Burt JB, Ji JL, Schleifer CH, Adkinson BD, Stämpfli P, Seifritz E, Repovs G, Krystal JH, Murray JD, Vollenweider FX, Anticevic A. Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor. ELife 2018, 7: e35082. PMID: 30355445, PMCID: PMC6202055, DOI: 10.7554/elife.35082.Peer-Reviewed Original ResearchConceptsLysergic acid diethylamideLSD effectsResting-state functional connectivityCortical gene expressionHealthy human participantsThalamic connectivityDopamine receptorsReceptor contributionNeurobiological effectsAgonist activityFunctional connectivityBrain connectivityAcid diethylamideReceptorsKetanserinNeuropharmacologyLSD mechanismCritical roleGene expressionAltered statesHuman participantsRational developmentSerotonin