2024
Internal tremors and vibrations in long COVID: a cross-sectional study
Zhou T, Sawano M, Arun A, Caraballo C, Michelsen T, McAlpine L, Bhattacharjee B, Lu Y, Khera R, Huang C, Warner F, Herrin J, Iwasaki A, Krumholz H. Internal tremors and vibrations in long COVID: a cross-sectional study. The American Journal Of Medicine 2024 PMID: 39069199, DOI: 10.1016/j.amjmed.2024.07.008.Peer-Reviewed Original ResearchNew-onset conditionsInternal tremorLong COVID symptomsCOVID symptomsNon-Hispanic whitesCross-sectional studyQuality of lifeVisual analogue scaleWorse healthHealth statusStudy participantsDemographic characteristicsAnalogue scaleOutcome variablesNeurological conditionsLong COVIDMast cell disordersTreatment experienceHealthComorbiditiesSymptomsMedian agePeopleCell disordersThe PAX LC Trial: A Decentralized, Phase 2, Randomized, Double-blind Study of Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir for Long COVID
Krumholz H, Sawano M, Bhattacharjee B, Caraballo C, Khera R, Li S, Herrin J, Coppi A, Holub J, Henriquez Y, Johnson M, Goddard T, Rocco E, Hummel A, Al Mouslmani M, Putrino D, Carr K, Carvajal-Gonzalez S, Charnas L, De Jesus M, Ziegler F, Iwasaki A. The PAX LC Trial: A Decentralized, Phase 2, Randomized, Double-blind Study of Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir for Long COVID. The American Journal Of Medicine 2024 PMID: 38735354, DOI: 10.1016/j.amjmed.2024.04.030.Peer-Reviewed Original ResearchLC trialPROMIS-29Participants' homesTargeting viral persistencePlacebo-controlled trialDouble-blind studyElectronic health recordsCore Outcome MeasuresLong COVIDEQ-5D-5LRepeated measures analysisEvidence-based treatmentsPhase 2Double-blindParticipant-centred approachStudy drugPrimary endpointSecondary endpointsCommunity-dwellingHealth recordsHealthcare utilizationContiguous US statesViral persistencePatient groupDrug treatmentLong COVID Characteristics and Experience: A Descriptive Study from the Yale LISTEN Research Cohort
Sawano M, Wu Y, Shah R, Zhou T, Arun A, Khosla P, Kaleem S, Vashist A, Bhattacharjee B, Ding Q, Lu Y, Caraballo C, Warner F, Huang C, Herrin J, Putrino D, Michelsen T, Fisher L, Adinig C, Iwasaki A, Krumholz H. Long COVID Characteristics and Experience: A Descriptive Study from the Yale LISTEN Research Cohort. The American Journal Of Medicine 2024 PMID: 38663793, DOI: 10.1016/j.amjmed.2024.04.015.Peer-Reviewed Original ResearchExperiences of peopleHealth statusLong COVIDLower health statusNew-onset conditionsCommunity support servicesNon-Hispanic whitesArray of healthQuality of lifeVisual analogue scaleMental healthPsychological distressPsychological statusDescriptive studyHealthcare systemMedian scoreSupport servicesResearch cohortSocial isolationDemographic characteristicsAnalogue scaleImpact of long COVIDHealthFinancial stressParticipants
2023
Distinguishing features of long COVID identified through immune profiling
Klein J, Wood J, Jaycox J, Dhodapkar R, Lu P, Gehlhausen J, Tabachnikova A, Greene K, Tabacof L, Malik A, Silva Monteiro V, Silva J, Kamath K, Zhang M, Dhal A, Ott I, Valle G, Peña-Hernández M, Mao T, Bhattacharjee B, Takahashi T, Lucas C, Song E, McCarthy D, Breyman E, Tosto-Mancuso J, Dai Y, Perotti E, Akduman K, Tzeng T, Xu L, Geraghty A, Monje M, Yildirim I, Shon J, Medzhitov R, Lutchmansingh D, Possick J, Kaminski N, Omer S, Krumholz H, Guan L, Dela Cruz C, van Dijk D, Ring A, Putrino D, Iwasaki A. Distinguishing features of long COVID identified through immune profiling. Nature 2023, 623: 139-148. PMID: 37748514, PMCID: PMC10620090, DOI: 10.1038/s41586-023-06651-y.Peer-Reviewed Original ResearchConceptsLong COVIDSARS-CoV-2Infection syndromeExaggerated humoral responseSoluble immune mediatorsEpstein-Barr virusPost-exertional malaiseCross-sectional studyHigher antibody responseImmune mediatorsImmune phenotypingImmune profilingHumoral responseAntibody responseLymphocyte populationsCOVID statusUnbiased machineCortisol levelsLC statusRelevant biomarkersViral pathogensSyndromeCOVIDFuture studiesBiological featuresIL-10/IL-6 ratio from nasal & oral swab samples, acts as an inflammatory indicator for COVID-19 patients infected with the delta variant
Biswas B, Roy S, Banerjee I, Jana S, Bhattacharjee B, Chakraborty S, Mondal A, Goswami R. IL-10/IL-6 ratio from nasal & oral swab samples, acts as an inflammatory indicator for COVID-19 patients infected with the delta variant. Heliyon 2023, 9: e16985. PMID: 37292329, PMCID: PMC10238278, DOI: 10.1016/j.heliyon.2023.e16985.Peer-Reviewed Original ResearchViral load patientsCOVID-19 patientsNon-vaccinated patientsViral loadIL-10/IL-6 ratioHyper-inflammatory immune responseMultiple pro-inflammatory cytokinesCT valuesIL-10/IL-6Control groupSwab samplesPro-inflammatory cytokinesRelease of multiple pro-inflammatory cytokinesOral swab samplesUninfected donorsICU supportStatus of vaccinationNasal swab samplesInflammatory indicatorsDisease progressionCytokine markersPatientsNon-vaccinated COVID-19 patientsNasal swabsUninfected individuals
2022
Influence of Sub-Inhibitory Dosage of Cefotaxime on Multidrug Resistant Staphylococcus haemolyticus Isolated from Sick Neonatal Care Unit
Chakraborty M, Bardhan T, Basu M, Bhattacharjee B. Influence of Sub-Inhibitory Dosage of Cefotaxime on Multidrug Resistant Staphylococcus haemolyticus Isolated from Sick Neonatal Care Unit. Antibiotics 2022, 11: 360. PMID: 35326823, PMCID: PMC8944431, DOI: 10.3390/antibiotics11030360.Peer-Reviewed Original ResearchExtracellular DNABiofilm formationS. haemolyticus isolatesBiofilm-forming abilityNon-susceptibilityGenerations of growthSick neonatal care unitCrystal violet assayAntibiotic non-susceptibilityNon-susceptible isolatesS. haemolyticusBiofilm productionNeonatal care unitStaphylococcus haemolyticusDosage of cefotaximeMDR isolatesExtracellular DNA levelsDoses of antibioticsConcentrations of cefotaximeCare of neonatesSub-optimal dosesCTX resistanceSepsis pathogensSub-optimal concentrationsNewborn infantsThe Species-Specific 282 Residue in the PB2 Subunit of the Polymerase Regulates RNA Synthesis and Replication of Influenza A Viruses Infecting Bat and Nonbat Hosts
Banerjee S, De A, Kedia N, Bhakta K, Wang L, Bhattacharjee B, Mondal A. The Species-Specific 282 Residue in the PB2 Subunit of the Polymerase Regulates RNA Synthesis and Replication of Influenza A Viruses Infecting Bat and Nonbat Hosts. Journal Of Virology 2022, 96: e02190-21. PMID: 35044213, PMCID: PMC8906409, DOI: 10.1128/jvi.02190-21.Peer-Reviewed Original ResearchConceptsBat influenza virusesInfluenza virus polymeraseInfluenza A virusVirus polymerasePB2 subunitIAV RNA polymeraseGenera of influenza virusesHost speciesAdaptation of influenza virusesInfluenza virusHuman cellsPolymerase subunit PB2RNA synthesis activitySpecies-specific signaturesHuman-specific signaturesAmino acid preferencesReduced polymerase activityAmino acid alterationsGlutamic acidA virusSurface antigen hemagglutininCross-species transmissionRNA polymerasePB2 proteinSignature residues
2021
Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes
Mandal P, Bhattacharjee B, Sen S, Bhattacharya A, Saha S, Chowdhury R, Mondal N, Chakrabarty B, Chatterjee T, Roy S, Sengupta S. Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes. Translational Oncology 2021, 15: 101256. PMID: 34717279, PMCID: PMC8564679, DOI: 10.1016/j.tranon.2021.101256.Peer-Reviewed Original ResearchSquamous cell carcinomaSquamous cell carcinoma casesLineage ACell carcinomaCervical squamous cell carcinomaE7 mRNA expressionHuman papillomavirus type 16Lineage A virusNon-malignant specimensAssociation of variantsDNA copy numberD lineageCytological outcomeHPV16 genomeEpisomal HPV16Sub-lineagesCopy numberIndian patientsA virusType 16Oncogenic phenotypeHPV16LineagesA1 virusesRisk allelesAssociation of clade-G SARS-CoV-2 viruses and age with increased mortality rates across 57 countries and India
Pandit B, Bhattacharjee S, Bhattacharjee B. Association of clade-G SARS-CoV-2 viruses and age with increased mortality rates across 57 countries and India. Infection Genetics And Evolution 2021, 90: 104734. PMID: 33508515, PMCID: PMC7839510, DOI: 10.1016/j.meegid.2021.104734.Peer-Reviewed Original ResearchConceptsIndication of population expansionNegative Tajima's D valuesAllele frequency spectrumTajima's D valuesSARS-CoV-2 sequencesAmino acid changesClade of virusesNucleotide diversityEvolutionary analysisLinkage disequilibriumPopulation expansionContribution of host factorsViral haplotypesClade GAcid changesSARS-CoV-2 variantsViral populationsHost factorsMortality rateVariantsViral factorsNetwork analysisCoronary heart diseaseSARS-CoV-2 virusVirus
2020
Prevalence of Colistin-Resistant, Carbapenem-Hydrolyzing Proteobacteria in Hospital Water Bodies and Out-Falls of West Bengal, India
Bardhan T, Chakraborty M, Bhattacharjee B. Prevalence of Colistin-Resistant, Carbapenem-Hydrolyzing Proteobacteria in Hospital Water Bodies and Out-Falls of West Bengal, India. International Journal Of Environmental Research And Public Health 2020, 17: 1007. PMID: 32033408, PMCID: PMC7037630, DOI: 10.3390/ijerph17031007.Peer-Reviewed Original ResearchConceptsColistin resistanceEosin methylene blue agarLevels of antibiotic resistanceNon-susceptible to meropenemPrevalence of colistin resistanceMethylene blue agarMeropenem-non-susceptiblePredominant speciesNon-susceptible isolatesCarbapenemase genesBlue agarAntibiotic resistanceMDR bacteriaNon-susceptibilityEnvironmental sourcesBacterial infectionsIsolatesGenesMeropenemHospitalSpeciesPrevalence patternsPrevalenceHospital wastewaterIndiscriminate use
2019
Bactericidal Activity of Lactic Acid against Clinical, Carbapenem-Hydrolyzing, Multi-Drug-Resistant Klebsiella pneumoniae Planktonic and Biofilm-Forming Cells
Bardhan T, Chakraborty M, Bhattacharjee B. Bactericidal Activity of Lactic Acid against Clinical, Carbapenem-Hydrolyzing, Multi-Drug-Resistant Klebsiella pneumoniae Planktonic and Biofilm-Forming Cells. Antibiotics 2019, 8: 181. PMID: 31600988, PMCID: PMC6963607, DOI: 10.3390/antibiotics8040181.Peer-Reviewed Original ResearchBiofilm-forming cellsPlanktonic cellsLactic acidEfficacy of lactic acidCarbapenem-resistant <i>Klebsiella pneumoniae</i>Time-kill assayOptimal incubation timeClinical isolatesBiofilm formsColony-forming unit countsInhibitory concentrationPreterm neonatesPlanktonBactericidal activityEfficacy parametersIsolatesIncubation timeCell countBiofilmWorld Health OrganizationUnit countsCellsCell damageGraded seriesHealth Organization
2018
Resistance profiles and resistome mapping of multidrug resistant carbapenem-hydrolyzing Klebsiella pneumoniae strains isolated from the nares of preterm neonates
Bhattacharjee B, Bardhan T, Chakraborty M, Basu M. Resistance profiles and resistome mapping of multidrug resistant carbapenem-hydrolyzing Klebsiella pneumoniae strains isolated from the nares of preterm neonates. International Journal Of Antimicrobial Agents 2018, 53: 535-537. PMID: 30572009, DOI: 10.1016/j.ijantimicag.2018.12.002.Peer-Reviewed Original Research
2016
Complete Genome Sequences of Eight Human Papillomavirus Type 16 Asian American and European Variant Isolates from Cervical Biopsies and Lesions in Indian Women
Mandal P, Bhattacharjee B, Sen S, Bhattacharya A, Chowdhury R, Mondal N, Sengupta S. Complete Genome Sequences of Eight Human Papillomavirus Type 16 Asian American and European Variant Isolates from Cervical Biopsies and Lesions in Indian Women. Microbiology Resource Announcements 2016, 4: e00243-16. PMID: 27198009, PMCID: PMC4878291, DOI: 10.1128/genomea.00243-16.Peer-Reviewed Original ResearchComplete genome sequenceGenome sequenceHuman papillomavirus type 16Asian-American variantsVariant isolatesPapillomaviridae familyPrimary etiological agentEtiological agent of cervical cancerAgent of cervical cancerType 16Papillomavirus typePrimary etiological agent of cervical cancerEuropean variantsSequenceAmerican variantHuman papillomavirus typeVariantsPapillomaviridaeIsolatesHPV16Cervical biopsy
2015
Limits and patterns of cytomegalovirus genomic diversity in humans
Renzette N, Pokalyuk C, Gibson L, Bhattacharjee B, Schleiss M, Hamprecht K, Yamamoto A, Mussi-Pinhata M, Britt W, Jensen J, Kowalik T. Limits and patterns of cytomegalovirus genomic diversity in humans. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: e4120-e4128. PMID: 26150505, PMCID: PMC4522815, DOI: 10.1073/pnas.1501880112.Peer-Reviewed Original ResearchConceptsGenomic diversityHuman hostGenome-wide mutationsHuman cytomegalovirusRecombination rate mapsHCMV populationsViral genomic diversityGenome beingRegulatory proteinsViral populationsDiversityPolymorphismHostPatient samplesDiverse regionsGenomeNatural infectionLociCongenitally infected infantsGenesMutationsProteinInfected infantsGlycoproteinRecombination
2014
RNA and β-Hemolysin of Group B Streptococcus Induce Interleukin-1β (IL-1β) by Activating NLRP3 Inflammasomes in Mouse Macrophages*
Gupta R, Ghosh S, Monks B, DeOliveira R, Tzeng T, Kalantari P, Nandy A, Bhattacharjee B, Chan J, Ferreira F, Rathinam V, Sharma S, Lien E, Silverman N, Fitzgerald K, Firon A, Trieu-Cuot P, Henneke P, Golenbock D. RNA and β-Hemolysin of Group B Streptococcus Induce Interleukin-1β (IL-1β) by Activating NLRP3 Inflammasomes in Mouse Macrophages*. Journal Of Biological Chemistry 2014, 289: 13701-13705. PMID: 24692555, PMCID: PMC4022842, DOI: 10.1074/jbc.c114.548982.Peer-Reviewed Original Research
2013
Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection
Renzette N, Gibson L, Bhattacharjee B, Fisher D, Schleiss M, Jensen J, Kowalik T. Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection. PLOS Genetics 2013, 9: e1003735. PMID: 24086142, PMCID: PMC3784496, DOI: 10.1371/journal.pgen.1003735.Peer-Reviewed Original ResearchConceptsPositive selectionCongenital HCMV infectionApplication of population genetic methodsHuman cytomegalovirus evolutionViral populationsPopulation genetic methodsPopulation genetic approachesHuman cytomegalovirusModels of demographyOpen reading frameHCMV populationsHCMV infectionPatterns of variationUnrelated hostsReading frameGenome populationsWeeks gestational ageGenetic approachesGenetic methodsDNA virusesHuman hostPervasive driverHost environmentCompartmental variablesViral evolutionDifferential Expression of HPV16 L2 Gene in Cervical Cancers Harboring Episomal HPV16 Genomes: Influence of Synonymous and Non-Coding Region Variations
Mandal P, Bhattacharjee B, Ghosh D, Mondal N, Chowdhury R, Roy S, Sengupta S. Differential Expression of HPV16 L2 Gene in Cervical Cancers Harboring Episomal HPV16 Genomes: Influence of Synonymous and Non-Coding Region Variations. PLOS ONE 2013, 8: e65647. PMID: 23762404, PMCID: PMC3675152, DOI: 10.1371/journal.pone.0065647.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCapsid ProteinsCarcinoma, Squamous CellFemaleGene DosageGene Expression Regulation, ViralGenome, ViralHost-Pathogen InteractionsHuman papillomavirus 16HumansMicroRNAsMiddle AgedOncogene Proteins, ViralOpen Reading FramesPapillomavirus InfectionsPlasmidsPolymorphism, GeneticPromoter Regions, GeneticRNA, MessengerSequence Analysis, DNAUterine Cervical NeoplasmsConceptsNon-coding regionsHPV16 genomeSynonymous variationNon-malignant samplesHuman codonsL2 genesWhole-genome sequence analysisShort non-coding regionHPV16 isolatesGenome sequence analysisMiRNA binding sitesWeak promoter activityHsa-mir-548Gene copy numberCaCx casesEpisomal HPV16 genomesSequence variationCoding regionSequence analysisGenomeNon-codingViral genomeEpisomal viral genomesCopy numberL2 ORF
2012
Some Novel Insights on HPV16 Related Cervical Cancer Pathogenesis Based on Analyses of LCR Methylation, Viral Load, E7 and E2/E4 Expressions
Ghosh D, Bhattacharjee B, Sen S, Premi L, Mukhopadhyay I, Chowdhury R, Roy S, Sengupta S. Some Novel Insights on HPV16 Related Cervical Cancer Pathogenesis Based on Analyses of LCR Methylation, Viral Load, E7 and E2/E4 Expressions. PLOS ONE 2012, 7: e44678. PMID: 22970286, PMCID: PMC3435323, DOI: 10.1371/journal.pone.0044678.Peer-Reviewed Original ResearchConceptsLong control regionViral loadViral genomeReplication originsCaCx casesEpisomal HPV16 genomesLack of methylationE7 mRNA expressionHuman papillomavirus 16Binding site IGene copy numberCervical cancer pathogenesisRepressor proteinBisulphite sequencingControl regionHPV16 genomeCervical carcinogenesisHost genesGenomeCervical cancerCopy numberViral transcriptionHPV16Cancer pathogenesisOncogene E7Genetic Analysis of Cytomegalovirus in Malignant Gliomas
Bhattacharjee B, Renzette N, Kowalik T. Genetic Analysis of Cytomegalovirus in Malignant Gliomas. Journal Of Virology 2012, 86: 6815-6824. PMID: 22496213, PMCID: PMC3393585, DOI: 10.1128/jvi.00015-12.Peer-Reviewed Original ResearchConceptsDNA copy numberViral DNA copy numberPresence of intact open reading framesCopy numberLong regionMalignant gliomasHigh amino acid sequence conservationAmino acid sequence conservationIntact open reading framesViral populationsHuman cytomegalovirusOpen reading frameAmino acid changesSingle gene productsGenome coverageGlioblastoma multiformeSequence conservationReading framePhylogenetic analysisHCMV prevalenceCore genesSequence analysisShort regionLow-grade tumorsGenetic analysis
2011
Extensive Genome-Wide Variability of Human Cytomegalovirus in Congenitally Infected Infants
Renzette N, Bhattacharjee B, Jensen J, Gibson L, Kowalik T. Extensive Genome-Wide Variability of Human Cytomegalovirus in Congenitally Infected Infants. PLOS Pathogens 2011, 7: e1001344. PMID: 21625576, PMCID: PMC3098220, DOI: 10.1371/journal.ppat.1001344.Peer-Reviewed Original ResearchConceptsRNA virusesReplication of RNA genomesGenome-wide variabilityPopulation genetic analysesRNA virus populationsHuman cytomegalovirusGenome wide studiesAmino acid levelsIntrahost populationsDsDNA genomeRNA genomeGenomic variabilityGenome typesPositive selectionGenetic analysisGenomeDNA virusesVirus populationsViral populationsWide studiesCongenital human cytomegalovirusImmune-mediated mechanismsCongenitally infected infantsSamples of neonatesFidelity replication