2015
Limits and patterns of cytomegalovirus genomic diversity in humans
Renzette N, Pokalyuk C, Gibson L, Bhattacharjee B, Schleiss M, Hamprecht K, Yamamoto A, Mussi-Pinhata M, Britt W, Jensen J, Kowalik T. Limits and patterns of cytomegalovirus genomic diversity in humans. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: e4120-e4128. PMID: 26150505, PMCID: PMC4522815, DOI: 10.1073/pnas.1501880112.Peer-Reviewed Original ResearchConceptsGenomic diversityHuman hostGenome-wide mutationsHuman cytomegalovirusRecombination rate mapsHCMV populationsViral genomic diversityGenome beingRegulatory proteinsViral populationsDiversityPolymorphismHostPatient samplesDiverse regionsGenomeNatural infectionLociCongenitally infected infantsGenesMutationsProteinInfected infantsGlycoproteinRecombination
2013
Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection
Renzette N, Gibson L, Bhattacharjee B, Fisher D, Schleiss M, Jensen J, Kowalik T. Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection. PLOS Genetics 2013, 9: e1003735. PMID: 24086142, PMCID: PMC3784496, DOI: 10.1371/journal.pgen.1003735.Peer-Reviewed Original ResearchConceptsPositive selectionCongenital HCMV infectionApplication of population genetic methodsHuman cytomegalovirus evolutionViral populationsPopulation genetic methodsPopulation genetic approachesHuman cytomegalovirusModels of demographyOpen reading frameHCMV populationsHCMV infectionPatterns of variationUnrelated hostsReading frameGenome populationsWeeks gestational ageGenetic approachesGenetic methodsDNA virusesHuman hostPervasive driverHost environmentCompartmental variablesViral evolution
2012
Genetic Analysis of Cytomegalovirus in Malignant Gliomas
Bhattacharjee B, Renzette N, Kowalik T. Genetic Analysis of Cytomegalovirus in Malignant Gliomas. Journal Of Virology 2012, 86: 6815-6824. PMID: 22496213, PMCID: PMC3393585, DOI: 10.1128/jvi.00015-12.Peer-Reviewed Original ResearchConceptsDNA copy numberViral DNA copy numberPresence of intact open reading framesCopy numberLong regionMalignant gliomasHigh amino acid sequence conservationAmino acid sequence conservationIntact open reading framesViral populationsHuman cytomegalovirusOpen reading frameAmino acid changesSingle gene productsGenome coverageGlioblastoma multiformeSequence conservationReading framePhylogenetic analysisHCMV prevalenceCore genesSequence analysisShort regionLow-grade tumorsGenetic analysis
2011
Extensive Genome-Wide Variability of Human Cytomegalovirus in Congenitally Infected Infants
Renzette N, Bhattacharjee B, Jensen J, Gibson L, Kowalik T. Extensive Genome-Wide Variability of Human Cytomegalovirus in Congenitally Infected Infants. PLOS Pathogens 2011, 7: e1001344. PMID: 21625576, PMCID: PMC3098220, DOI: 10.1371/journal.ppat.1001344.Peer-Reviewed Original ResearchConceptsRNA virusesReplication of RNA genomesGenome-wide variabilityPopulation genetic analysesRNA virus populationsHuman cytomegalovirusGenome wide studiesAmino acid levelsIntrahost populationsDsDNA genomeRNA genomeGenomic variabilityGenome typesPositive selectionGenetic analysisGenomeDNA virusesVirus populationsViral populationsWide studiesCongenital human cytomegalovirusImmune-mediated mechanismsCongenitally infected infantsSamples of neonatesFidelity replication