Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection
Renzette N, Gibson L, Bhattacharjee B, Fisher D, Schleiss M, Jensen J, Kowalik T. Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection. PLOS Genetics 2013, 9: e1003735. PMID: 24086142, PMCID: PMC3784496, DOI: 10.1371/journal.pgen.1003735.Peer-Reviewed Original ResearchConceptsPositive selectionCongenital HCMV infectionApplication of population genetic methodsHuman cytomegalovirus evolutionViral populationsPopulation genetic methodsPopulation genetic approachesHuman cytomegalovirusModels of demographyOpen reading frameHCMV populationsHCMV infectionPatterns of variationUnrelated hostsReading frameGenome populationsWeeks gestational ageGenetic approachesGenetic methodsDNA virusesHuman hostPervasive driverHost environmentCompartmental variablesViral evolutionDifferential Expression of HPV16 L2 Gene in Cervical Cancers Harboring Episomal HPV16 Genomes: Influence of Synonymous and Non-Coding Region Variations
Mandal P, Bhattacharjee B, Ghosh D, Mondal N, Chowdhury R, Roy S, Sengupta S. Differential Expression of HPV16 L2 Gene in Cervical Cancers Harboring Episomal HPV16 Genomes: Influence of Synonymous and Non-Coding Region Variations. PLOS ONE 2013, 8: e65647. PMID: 23762404, PMCID: PMC3675152, DOI: 10.1371/journal.pone.0065647.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCapsid ProteinsCarcinoma, Squamous CellFemaleGene DosageGene Expression Regulation, ViralGenome, ViralHost-Pathogen InteractionsHuman papillomavirus 16HumansMicroRNAsMiddle AgedOncogene Proteins, ViralOpen Reading FramesPapillomavirus InfectionsPlasmidsPolymorphism, GeneticPromoter Regions, GeneticRNA, MessengerSequence Analysis, DNAUterine Cervical NeoplasmsConceptsNon-coding regionsHPV16 genomeSynonymous variationNon-malignant samplesHuman codonsL2 genesWhole-genome sequence analysisShort non-coding regionHPV16 isolatesGenome sequence analysisMiRNA binding sitesWeak promoter activityHsa-mir-548Gene copy numberCaCx casesEpisomal HPV16 genomesSequence variationCoding regionSequence analysisGenomeNon-codingViral genomeEpisomal viral genomesCopy numberL2 ORF