2013
Differential Expression of HPV16 L2 Gene in Cervical Cancers Harboring Episomal HPV16 Genomes: Influence of Synonymous and Non-Coding Region Variations
Mandal P, Bhattacharjee B, Ghosh D, Mondal N, Chowdhury R, Roy S, Sengupta S. Differential Expression of HPV16 L2 Gene in Cervical Cancers Harboring Episomal HPV16 Genomes: Influence of Synonymous and Non-Coding Region Variations. PLOS ONE 2013, 8: e65647. PMID: 23762404, PMCID: PMC3675152, DOI: 10.1371/journal.pone.0065647.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCapsid ProteinsCarcinoma, Squamous CellFemaleGene DosageGene Expression Regulation, ViralGenome, ViralHost-Pathogen InteractionsHuman papillomavirus 16HumansMicroRNAsMiddle AgedOncogene Proteins, ViralOpen Reading FramesPapillomavirus InfectionsPlasmidsPolymorphism, GeneticPromoter Regions, GeneticRNA, MessengerSequence Analysis, DNAUterine Cervical NeoplasmsConceptsNon-coding regionsHPV16 genomeSynonymous variationNon-malignant samplesHuman codonsL2 genesWhole-genome sequence analysisShort non-coding regionHPV16 isolatesGenome sequence analysisMiRNA binding sitesWeak promoter activityHsa-mir-548Gene copy numberCaCx casesEpisomal HPV16 genomesSequence variationCoding regionSequence analysisGenomeNon-codingViral genomeEpisomal viral genomesCopy numberL2 ORF
2012
Genetic Analysis of Cytomegalovirus in Malignant Gliomas
Bhattacharjee B, Renzette N, Kowalik T. Genetic Analysis of Cytomegalovirus in Malignant Gliomas. Journal Of Virology 2012, 86: 6815-6824. PMID: 22496213, PMCID: PMC3393585, DOI: 10.1128/jvi.00015-12.Peer-Reviewed Original ResearchConceptsDNA copy numberViral DNA copy numberPresence of intact open reading framesCopy numberLong regionMalignant gliomasHigh amino acid sequence conservationAmino acid sequence conservationIntact open reading framesViral populationsHuman cytomegalovirusOpen reading frameAmino acid changesSingle gene productsGenome coverageGlioblastoma multiformeSequence conservationReading framePhylogenetic analysisHCMV prevalenceCore genesSequence analysisShort regionLow-grade tumorsGenetic analysis