2015
Limits and patterns of cytomegalovirus genomic diversity in humans
Renzette N, Pokalyuk C, Gibson L, Bhattacharjee B, Schleiss M, Hamprecht K, Yamamoto A, Mussi-Pinhata M, Britt W, Jensen J, Kowalik T. Limits and patterns of cytomegalovirus genomic diversity in humans. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: e4120-e4128. PMID: 26150505, PMCID: PMC4522815, DOI: 10.1073/pnas.1501880112.Peer-Reviewed Original ResearchConceptsGenomic diversityHuman hostGenome-wide mutationsHuman cytomegalovirusRecombination rate mapsHCMV populationsViral genomic diversityGenome beingRegulatory proteinsViral populationsDiversityPolymorphismHostPatient samplesDiverse regionsGenomeNatural infectionLociCongenitally infected infantsGenesMutationsProteinInfected infantsGlycoproteinRecombination
2013
Differential Expression of HPV16 L2 Gene in Cervical Cancers Harboring Episomal HPV16 Genomes: Influence of Synonymous and Non-Coding Region Variations
Mandal P, Bhattacharjee B, Ghosh D, Mondal N, Chowdhury R, Roy S, Sengupta S. Differential Expression of HPV16 L2 Gene in Cervical Cancers Harboring Episomal HPV16 Genomes: Influence of Synonymous and Non-Coding Region Variations. PLOS ONE 2013, 8: e65647. PMID: 23762404, PMCID: PMC3675152, DOI: 10.1371/journal.pone.0065647.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCapsid ProteinsCarcinoma, Squamous CellFemaleGene DosageGene Expression Regulation, ViralGenome, ViralHost-Pathogen InteractionsHuman papillomavirus 16HumansMicroRNAsMiddle AgedOncogene Proteins, ViralOpen Reading FramesPapillomavirus InfectionsPlasmidsPolymorphism, GeneticPromoter Regions, GeneticRNA, MessengerSequence Analysis, DNAUterine Cervical NeoplasmsConceptsNon-coding regionsHPV16 genomeSynonymous variationNon-malignant samplesHuman codonsL2 genesWhole-genome sequence analysisShort non-coding regionHPV16 isolatesGenome sequence analysisMiRNA binding sitesWeak promoter activityHsa-mir-548Gene copy numberCaCx casesEpisomal HPV16 genomesSequence variationCoding regionSequence analysisGenomeNon-codingViral genomeEpisomal viral genomesCopy numberL2 ORF
2005
HPV16 E2 gene disruption and polymorphisms of E2 and LCR: Some significant associations with cervical cancer in Indian women
Bhattacharjee B, Sengupta S. HPV16 E2 gene disruption and polymorphisms of E2 and LCR: Some significant associations with cervical cancer in Indian women. Gynecologic Oncology 2005, 100: 372-378. PMID: 16246404, DOI: 10.1016/j.ygyno.2005.09.016.Peer-Reviewed Original ResearchConceptsE2 disruptionE2 geneE2 gene disruptionIntact E2 geneIndian womenBi-directional sequencingAsian-American variantsNucleotide sequence alterationsDNA-binding regionHPV16 E2 geneCaCx developmentHPV16 isolatesCompared to controlsChi-square testCaCx casesFisher's exactCervical cancerViral factorsHPV16Nucleotide variationsE subgroupGene disruptionSequence alterationsPCR amplificationNucleotide