Some Novel Insights on HPV16 Related Cervical Cancer Pathogenesis Based on Analyses of LCR Methylation, Viral Load, E7 and E2/E4 Expressions
Ghosh D, Bhattacharjee B, Sen S, Premi L, Mukhopadhyay I, Chowdhury R, Roy S, Sengupta S. Some Novel Insights on HPV16 Related Cervical Cancer Pathogenesis Based on Analyses of LCR Methylation, Viral Load, E7 and E2/E4 Expressions. PLOS ONE 2012, 7: e44678. PMID: 22970286, PMCID: PMC3435323, DOI: 10.1371/journal.pone.0044678.Peer-Reviewed Original ResearchConceptsLong control regionViral loadViral genomeReplication originsCaCx casesEpisomal HPV16 genomesLack of methylationE7 mRNA expressionHuman papillomavirus 16Binding site IGene copy numberCervical cancer pathogenesisRepressor proteinBisulphite sequencingControl regionHPV16 genomeCervical carcinogenesisHost genesGenomeCervical cancerCopy numberViral transcriptionHPV16Cancer pathogenesisOncogene E7