2013
Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection
Renzette N, Gibson L, Bhattacharjee B, Fisher D, Schleiss M, Jensen J, Kowalik T. Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection. PLOS Genetics 2013, 9: e1003735. PMID: 24086142, PMCID: PMC3784496, DOI: 10.1371/journal.pgen.1003735.Peer-Reviewed Original ResearchConceptsPositive selectionCongenital HCMV infectionApplication of population genetic methodsHuman cytomegalovirus evolutionViral populationsPopulation genetic methodsPopulation genetic approachesHuman cytomegalovirusModels of demographyOpen reading frameHCMV populationsHCMV infectionPatterns of variationUnrelated hostsReading frameGenome populationsWeeks gestational ageGenetic approachesGenetic methodsDNA virusesHuman hostPervasive driverHost environmentCompartmental variablesViral evolution
2011
Extensive Genome-Wide Variability of Human Cytomegalovirus in Congenitally Infected Infants
Renzette N, Bhattacharjee B, Jensen J, Gibson L, Kowalik T. Extensive Genome-Wide Variability of Human Cytomegalovirus in Congenitally Infected Infants. PLOS Pathogens 2011, 7: e1001344. PMID: 21625576, PMCID: PMC3098220, DOI: 10.1371/journal.ppat.1001344.Peer-Reviewed Original ResearchConceptsRNA virusesReplication of RNA genomesGenome-wide variabilityPopulation genetic analysesRNA virus populationsHuman cytomegalovirusGenome wide studiesAmino acid levelsIntrahost populationsDsDNA genomeRNA genomeGenomic variabilityGenome typesPositive selectionGenetic analysisGenomeDNA virusesVirus populationsViral populationsWide studiesCongenital human cytomegalovirusImmune-mediated mechanismsCongenitally infected infantsSamples of neonatesFidelity replication