2013
Differential Expression of HPV16 L2 Gene in Cervical Cancers Harboring Episomal HPV16 Genomes: Influence of Synonymous and Non-Coding Region Variations
Mandal P, Bhattacharjee B, Ghosh D, Mondal N, Chowdhury R, Roy S, Sengupta S. Differential Expression of HPV16 L2 Gene in Cervical Cancers Harboring Episomal HPV16 Genomes: Influence of Synonymous and Non-Coding Region Variations. PLOS ONE 2013, 8: e65647. PMID: 23762404, PMCID: PMC3675152, DOI: 10.1371/journal.pone.0065647.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCapsid ProteinsCarcinoma, Squamous CellFemaleGene DosageGene Expression Regulation, ViralGenome, ViralHost-Pathogen InteractionsHuman papillomavirus 16HumansMicroRNAsMiddle AgedOncogene Proteins, ViralOpen Reading FramesPapillomavirus InfectionsPlasmidsPolymorphism, GeneticPromoter Regions, GeneticRNA, MessengerSequence Analysis, DNAUterine Cervical NeoplasmsConceptsNon-coding regionsHPV16 genomeSynonymous variationNon-malignant samplesHuman codonsL2 genesWhole-genome sequence analysisShort non-coding regionHPV16 isolatesGenome sequence analysisMiRNA binding sitesWeak promoter activityHsa-mir-548Gene copy numberCaCx casesEpisomal HPV16 genomesSequence variationCoding regionSequence analysisGenomeNon-codingViral genomeEpisomal viral genomesCopy numberL2 ORF
2008
Characterization of sequence variations within HPV16 isolates among Indian women: Prediction of causal role of rare non-synonymous variations within intact isolates in cervical cancer pathogenesis
Bhattacharjee B, Mandal N, Roy S, Sengupta S. Characterization of sequence variations within HPV16 isolates among Indian women: Prediction of causal role of rare non-synonymous variations within intact isolates in cervical cancer pathogenesis. Virology 2008, 377: 143-150. PMID: 18495198, DOI: 10.1016/j.virol.2008.04.007.Peer-Reviewed Original ResearchConceptsNon-synonymous changesCharacterization of sequence variationsPolymorphic variationDeleterious to protein functionHPV16 isolatesNon-synonymous variationsRare non-synonymous variationsDeleterious variationHaplotype backgroundNucleotide variationsSIFTS databaseDeleterious mutationsSequence variationSequence variantsProtein functionHPV16 genomeHaplotype analysisHaplotypesFunctional validationCervical cancer pathogenesisE-12IsolatesCaCx developmentCancer pathogenesisProductive infection
2005
HPV16 E2 gene disruption and polymorphisms of E2 and LCR: Some significant associations with cervical cancer in Indian women
Bhattacharjee B, Sengupta S. HPV16 E2 gene disruption and polymorphisms of E2 and LCR: Some significant associations with cervical cancer in Indian women. Gynecologic Oncology 2005, 100: 372-378. PMID: 16246404, DOI: 10.1016/j.ygyno.2005.09.016.Peer-Reviewed Original ResearchConceptsE2 disruptionE2 geneE2 gene disruptionIntact E2 geneIndian womenBi-directional sequencingAsian-American variantsNucleotide sequence alterationsDNA-binding regionHPV16 E2 geneCaCx developmentHPV16 isolatesCompared to controlsChi-square testCaCx casesFisher's exactCervical cancerViral factorsHPV16Nucleotide variationsE subgroupGene disruptionSequence alterationsPCR amplificationNucleotide