2021
Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes
Mandal P, Bhattacharjee B, Sen S, Bhattacharya A, Saha S, Chowdhury R, Mondal N, Chakrabarty B, Chatterjee T, Roy S, Sengupta S. Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes. Translational Oncology 2021, 15: 101256. PMID: 34717279, PMCID: PMC8564679, DOI: 10.1016/j.tranon.2021.101256.Peer-Reviewed Original ResearchSquamous cell carcinomaSquamous cell carcinoma casesLineage ACell carcinomaCervical squamous cell carcinomaE7 mRNA expressionHuman papillomavirus type 16Lineage A virusNon-malignant specimensAssociation of variantsDNA copy numberD lineageCytological outcomeHPV16 genomeEpisomal HPV16Sub-lineagesCopy numberIndian patientsA virusType 16Oncogenic phenotypeHPV16LineagesA1 virusesRisk alleles
2012
Some Novel Insights on HPV16 Related Cervical Cancer Pathogenesis Based on Analyses of LCR Methylation, Viral Load, E7 and E2/E4 Expressions
Ghosh D, Bhattacharjee B, Sen S, Premi L, Mukhopadhyay I, Chowdhury R, Roy S, Sengupta S. Some Novel Insights on HPV16 Related Cervical Cancer Pathogenesis Based on Analyses of LCR Methylation, Viral Load, E7 and E2/E4 Expressions. PLOS ONE 2012, 7: e44678. PMID: 22970286, PMCID: PMC3435323, DOI: 10.1371/journal.pone.0044678.Peer-Reviewed Original ResearchConceptsLong control regionViral loadViral genomeReplication originsCaCx casesEpisomal HPV16 genomesLack of methylationE7 mRNA expressionHuman papillomavirus 16Binding site IGene copy numberCervical cancer pathogenesisRepressor proteinBisulphite sequencingControl regionHPV16 genomeCervical carcinogenesisHost genesGenomeCervical cancerCopy numberViral transcriptionHPV16Cancer pathogenesisOncogene E7