2012
Some Novel Insights on HPV16 Related Cervical Cancer Pathogenesis Based on Analyses of LCR Methylation, Viral Load, E7 and E2/E4 Expressions
Ghosh D, Bhattacharjee B, Sen S, Premi L, Mukhopadhyay I, Chowdhury R, Roy S, Sengupta S. Some Novel Insights on HPV16 Related Cervical Cancer Pathogenesis Based on Analyses of LCR Methylation, Viral Load, E7 and E2/E4 Expressions. PLOS ONE 2012, 7: e44678. PMID: 22970286, PMCID: PMC3435323, DOI: 10.1371/journal.pone.0044678.Peer-Reviewed Original ResearchConceptsLong control regionViral loadViral genomeReplication originsCaCx casesEpisomal HPV16 genomesLack of methylationE7 mRNA expressionHuman papillomavirus 16Binding site IGene copy numberCervical cancer pathogenesisRepressor proteinBisulphite sequencingControl regionHPV16 genomeCervical carcinogenesisHost genesGenomeCervical cancerCopy numberViral transcriptionHPV16Cancer pathogenesisOncogene E7
2006
CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2
Bhattacharjee B, Sengupta S. CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2. Virology 2006, 354: 280-285. PMID: 16905170, DOI: 10.1016/j.virol.2006.06.018.Peer-Reviewed Original ResearchConceptsLong control regionE2 binding sitesP97 promoterCervical cancerNormal controlsAssociated with cervical cancerCytologically normal controlsIntact E2 geneHuman papillomavirus type 16Binding sitesMspI restriction digestionRegulate transcriptionRepressor activityHPV-16CaCx samplesCpG methylationControl regionIntact E2Restriction digestionE7 genesType 16E2 geneCaCxMalignant samplesSite methylation