2019
Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity
Stutz B, Nasrallah C, Nigro M, Curry D, Liu ZW, Gao XB, Elsworth JD, Mintz L, Horvath TL. Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity. Molecular Metabolism 2019, 24: 120-138. PMID: 30833218, PMCID: PMC6531791, DOI: 10.1016/j.molmet.2019.02.005.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsDopaminergic NeuronsGhrelinMiceMPTP PoisoningNeuroprotective AgentsPeptide FragmentsReceptors, GhrelinSubstantia NigraConceptsSN DA neuronsDA neuronsSubstantia nigraDA cellsDopamine outputNeuronal protectionNeuronal survivalParkinson's diseaseDA neuron survivalDA neuronal survivalDesigner drugs (DREADD) technologyNeuronal pacemaker activityElectrical activityMouse substantia nigraElectric activityNeuron electrical activityAnimal motor behaviorGhrelin activationGHSR activationTetrahydropyridine (MPTP) treatmentNeuroprotective factorsNeuron survivalDopamine neuronsGhrelin receptorExogenous administration
2018
Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson’s Disease
Curry DW, Stutz B, Andrews ZB, Elsworth JD. Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson’s Disease. Journal Of Parkinson's Disease 2018, 8: 161-181. PMID: 29614701, PMCID: PMC6004921, DOI: 10.3233/jpd-171296.Peer-Reviewed Original ResearchMeSH KeywordsAlpha-SynucleinAMP-Activated Protein KinasesAnimalsAutophagyBrainDopaminergic NeuronsHumansNeuroprotective AgentsParkinson DiseaseSignal TransductionConceptsSerine/threonine kinaseFunction of AMPKParkinson's diseaseCellular energy balanceThreonine kinaseCellular stressorsIntracellular α-synuclein aggregatesProtein kinaseAMPK activationAMPK activityNumerous dietary supplementsPreclinical PD modelsNigrostriatal dopaminergic neuronsBroad neuroprotective effectsCell deathCommon neurodegenerative disorderAMPKΑ-synuclein aggregatesNeuroprotective treatmentNeuroprotective strategiesNeuroprotective effectsNeuronal atrophyPD patientsDopaminergic neuronsKinase