2019
A Pilot Study of a Standardized Smoking Cessation Intervention for Patients with Vascular Disease
Rajaee S, Holder T, Indes JE, Muhs B, Sarac T, Sumpio B, Toll BA, Ochoa Chaar CI. A Pilot Study of a Standardized Smoking Cessation Intervention for Patients with Vascular Disease. Annals Of Vascular Surgery 2019, 61: 91-99.e3. PMID: 31449932, DOI: 10.1016/j.avsg.2019.06.017.Peer-Reviewed Original ResearchMeSH KeywordsAneurysmCardiovascular AgentsCholinergic AgentsConnecticutEndovascular ProceduresFemaleHumansMaleMiddle AgedNicotinePatient Education as TopicPeripheral Arterial DiseasePilot ProjectsRisk FactorsRisk Reduction BehaviorSmokersSmokingSmoking CessationTime FactorsTobacco Use Cessation DevicesTransdermal PatchTreatment OutcomeVascular Surgical ProceduresConceptsSmoking cessation interventionIntervention groupSurgery providersPrimary outcomeCessation interventionsExact testBrief smoking cessation counselingCurrent smoking cessation practicesCarbon monoxide breath testingSmoking cessation counselingSmoking cessation practicesVascular surgery serviceSmoking cessation counseling sessionsTertiary care centerFree nicotine patchesSmoking cessation programOpen surgical proceduresOutpatient smoking cessation programFisher's exact testCessation counselingVascular complicationsStandard careNicotine patchNicotine replacementVascular patients
2006
Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-κB, and AP-1
Ueno H, Pradhan S, Schlessel D, Hirasawa H, Sumpio BE. Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-κB, and AP-1. Cardiovascular Toxicology 2006, 6: 39-50. PMID: 16845181, DOI: 10.1385/ct:6:1:39.Peer-Reviewed Original ResearchConceptsHuman umbilical vein endothelial cellsICAM-1VCAM-1NF-κBAdhesion moleculesP38 mitogen-activated protein kinaseProtein kinase CMitogen-activated protein kinaseVascular cell adhesion moleculeEndothelial cellsExposure of HUVECsCellular adhesion molecule expressionAP-1Vascular endothelial cell expressionMajor risk factorEffects of nicotineEtiology of atherosclerosisP38 MAPKAdhesion molecule expressionIntercellular adhesion moleculeTranscription factor NF-κBCellular adhesion moleculesEndothelial cell expressionFactor NF-κBUmbilical vein endothelial cells
2005
Nicotine induces mitogen-activated protein kinase dependent vascular smooth muscle cell migration
Di Luozzo G, Pradhan S, Dhadwal AK, Chen A, Ueno H, Sumpio BE. Nicotine induces mitogen-activated protein kinase dependent vascular smooth muscle cell migration. Atherosclerosis 2005, 178: 271-277. PMID: 15694934, DOI: 10.1016/j.atherosclerosis.2004.09.017.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cell migrationSmooth muscle cell migrationMuscle cell migrationInhibitors of p38VSMC migrationMitogen-activated protein kinaseEndothelial cellsDevelopment of atherosclerosisEffects of nicotineCell migrationWestern blotting methodInjury modelVascular endotheliumCigarette smokeBoyden chamber chemotaxis assaysAortic VSMCsChemotactic effectMAPKs p38NicotineChemoattractant moleculesChemotaxis assaysCellular mechanismsUltrastructural changesVSMCP44/42 activation
2001
Nicotine: a review of its role in atherosclerosis1 1No competing interests declared.
Kilaru S, Frangos S, Chen A, Gortler D, Dhadwal A, Araim O, Sumpio B. Nicotine: a review of its role in atherosclerosis1 1No competing interests declared. Journal Of The American College Of Surgeons 2001, 193: 538-546. PMID: 11708512, DOI: 10.1016/s1072-7515(01)01059-6.Peer-Reviewed Original Research