2014
A comparison of open and endovascular revascularization for chronic mesenteric ischemia in a clinical decision model
Hogendoorn W, Hunink MG, Schlösser FJ, Moll FL, Muhs BE, Sumpio BE. A comparison of open and endovascular revascularization for chronic mesenteric ischemia in a clinical decision model. Journal Of Vascular Surgery 2014, 60: 715-725.e2. PMID: 24721175, DOI: 10.1016/j.jvs.2014.03.009.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overComparative Effectiveness ResearchComputer SimulationCost-Benefit AnalysisDecision Support TechniquesEndovascular ProceduresFemaleHealth Care CostsHumansIschemiaMaleMarkov ChainsMesenteric IschemiaMiddle AgedPatient SelectionPredictive Value of TestsQuality of LifeQuality-Adjusted Life YearsReoperationRisk AssessmentRisk FactorsSex FactorsTime FactorsTreatment OutcomeVascular DiseasesVascular PatencyVascular Surgical ProceduresConceptsChronic mesenteric ischemiaIncremental cost-effectiveness ratioEndovascular revascularizationCost-effectiveness ratioMesenteric ischemiaFemale patientsMortality riskAge groupsGood short-term resultsDisease-specific mortality riskPatients 60 yearsOverall mortality riskMarkov state transition modelTreatment of choiceExpensive treatment strategiesShort-term resultsHealth care perspectiveHealth care costsDifferent clinical scenariosProbabilistic sensitivity analysesClinical decision modelDecision analysis modelOlder patientsConservative managementYounger patients
2013
Too small to fail: The prisoner's dilemma
Sumpio BE. Too small to fail: The prisoner's dilemma. Journal Of Vascular Surgery 2013, 57: 1415-1421. PMID: 23601596, DOI: 10.1016/j.jvs.2013.01.005.Peer-Reviewed Original ResearchCooperative BehaviorCost-Benefit AnalysisEndovascular ProceduresGame TheoryHealth Care CostsHumansInterdisciplinary CommunicationOrganizational ObjectivesPatient Care TeamPractice Guidelines as TopicSeverity of Illness IndexSocieties, MedicalSpecialties, SurgicalTreatment OutcomeVascular DiseasesVascular Surgical Procedures
2004
The role of thrombospondin-1 in human disease1
Esemuede N, Lee T, Pierre-Paul D, Sumpio BE, Gahtan V. The role of thrombospondin-1 in human disease1. Journal Of Surgical Research 2004, 122: 135-142. PMID: 15522326, DOI: 10.1016/j.jss.2004.05.015.Peer-Reviewed Original ResearchEffects of Cyclic Strain on Vascular Cells
Kakisis JD, Liapis CD, Sumpio BE. Effects of Cyclic Strain on Vascular Cells. Endothelium 2004, 11: 17-28. PMID: 15203876, DOI: 10.1080/10623320490432452.Peer-Reviewed Original ResearchConceptsCAMP-responsive elementVascular cell morphologyExtracellular mechanical signalsMitogen-activated protein kinaseProtein kinase CPlatelet-derived growth factor receptorEarly growth responseCells senseNumerous genesActivator proteinTranscription factorsProtein kinaseGrowth factor receptorAP-2Chemical signalsSecond messengerKinase CG proteinsMechanical signalsCell nucleiGrowth responseIon channelsCell morphologyFactor receptorCell proliferation
2003
Oscillatory shear stress increases smooth muscle cell proliferation and akt phosphorylation
Haga M, Yamashita A, Paszkowiak J, Sumpio BE, Dardik A. Oscillatory shear stress increases smooth muscle cell proliferation and akt phosphorylation. Journal Of Vascular Surgery 2003, 37: 1277-1284. PMID: 12764276, DOI: 10.1016/s0741-5214(03)00329-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCattleCell Physiological PhenomenaDisease Models, AnimalHemodynamicsIn Vitro TechniquesMyocytes, Smooth MuscleOscillometryPhosphatidylinositol 3-KinasesPhosphorylationProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktShear StrengthSignal TransductionStress, PhysiologicalVascular DiseasesConceptsSignal transduction pathwaysAkt phosphorylationTransduction pathwaysPI3K-Akt signal transduction pathwaySmooth muscle cell proliferationMuscle cell proliferationCell proliferationControl cellsOscillatory shear stressMaximal phosphorylationPI3K inhibitorsCell numberSurvival pathwaysAkt activationBovine aortic SMCSMC survivalInhibitor LY294002Akt pathwayPhosphorylationWestern blot techniqueControl survivalDNA synthesisK inhibitorsAortic SMCsPathway
2000
Vascular drugs in the new millennium11No competing interests declared.
Frangos S, Chen A, Sumpio B. Vascular drugs in the new millennium11No competing interests declared. Journal Of The American College Of Surgeons 2000, 191: 76-92. PMID: 10898187, DOI: 10.1016/s1072-7515(00)00292-1.Peer-Reviewed Original ResearchAbciximabAnimalsAnistreplaseAntibodies, MonoclonalAnticoagulantsAspirinChondroitin SulfatesClopidogrelDermatan SulfateDrug CombinationsFibrinolytic AgentsHeparin, Low-Molecular-WeightHeparitin SulfateHumansImmunoglobulin Fab FragmentsIntermittent ClaudicationPlatelet Aggregation InhibitorsStreptokinaseTiclopidineVascular DiseasesVenous Thrombosis
1998
Understanding molecular biology.
Gahtan V, Peyman JA, Sumpio BE. Understanding molecular biology. Seminars In Vascular Surgery 1998, 11: 125-33. PMID: 9763112.Peer-Reviewed Original Research
1993
Defecation Syncope Secondary to Functional Inferior Vena Caval Obstruction During a Valsalva Maneuver
Brophy C, Evans L, Sumpio B. Defecation Syncope Secondary to Functional Inferior Vena Caval Obstruction During a Valsalva Maneuver. Annals Of Vascular Surgery 1993, 7: 374-377. PMID: 8268080, DOI: 10.1007/bf02002893.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PressureDefecationFemaleHumansSyncopeValsalva ManeuverVascular DiseasesVena Cava, InferiorConceptsValsalva maneuverDefecation syncopeInferior vena cava obstructionInferior vena caval obstructionPreoperative hemodynamic assessmentVena caval obstructionEffective surgical approachVena cava obstructionContinuous hemodynamic monitoringIVC obstructionCava obstructionCaval obstructionBlood pressureFunctional obstructionHemodynamic assessmentHemodynamic monitoringDiaphragmatic hiatusSurgical approachTransesophageal ultrasonographyFunctional disordersIVC patencyIntraoperative approachSurgical mobilizationObstructionExtensive mobilization