1997
Regulation of tPA in endothelial cells exposed to cyclic strain: role of CRE, AP-2, and SSRE binding sites
Sumpio B, Chang R, Xu W, Wang X, Du W. Regulation of tPA in endothelial cells exposed to cyclic strain: role of CRE, AP-2, and SSRE binding sites. American Journal Of Physiology 1997, 273: c1441-c1448. PMID: 9374627, DOI: 10.1152/ajpcell.1997.273.5.c1441.Peer-Reviewed Original ResearchAnimalsAorta, ThoracicBase SequenceBinding SitesCattleCell CycleCell NucleusCells, CulturedChloramphenicol O-AcetyltransferaseCyclic AMP Response Element-Binding ProteinDNA-Binding ProteinsEndothelium, VascularGene Expression Regulation, EnzymologicHumansKineticsMutagenesis, Site-DirectedOligodeoxyribonucleotidesPromoter Regions, GeneticRecombinant Fusion ProteinsStress, MechanicalTime FactorsTissue Plasminogen ActivatorTranscription Factor AP-2Transcription FactorsTransfectionTissue plasminogen activator-biologic perspective for surgeons.
Chang R, Powell RJ, Sumpio BE. Tissue plasminogen activator-biologic perspective for surgeons. Journal Of The American College Of Surgeons 1997, 184: 529-39. PMID: 9145078.Peer-Reviewed Original ResearchGene Regulation by Mechanical Forces
Oluwole BO, Du W, Mills I, Sumpio BE. Gene Regulation by Mechanical Forces. Endothelium 1997, 5: 85-93. PMID: 9237042, DOI: 10.3109/10623329709079866.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCattleCell Adhesion MoleculesCell Culture TechniquesCells, CulturedEndothelinsEndothelium, VascularEpoprostenolFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesGene Expression RegulationHemorheologyHumansMechanoreceptorsMembranes, ArtificialNitric OxideProtein-Tyrosine KinasesSignal TransductionStress, MechanicalTissue Plasminogen ActivatorTranscription FactorsTranscription, GeneticVacuumConceptsEndothelial cellsEndothelial cell functionCyclic strainVasoactive mediatorsSecond messenger cascadesNitric oxideBlood vesselsMechanical forcesCell functionMechanical deformationFlow of bloodMessenger cascadesLuminal surfaceSpecific response elementsPromoter geneResponse elementExternal forcesMediatorsCytoskeletal changesCellsForceProstacyclinExpressionTranscription levels
1992
Intracellular cyclic AMP levels in endothelial cells subjected to cyclic strain in vitro
Iba T, Mills I, Sumpio B. Intracellular cyclic AMP levels in endothelial cells subjected to cyclic strain in vitro. Journal Of Surgical Research 1992, 52: 625-630. PMID: 1326680, DOI: 10.1016/0022-4804(92)90140-u.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedCyclic AMPEndothelium, VascularHumansSaphenous VeinStress, MechanicalTissue Plasminogen ActivatorTissue Plasminogen Activator Expression in Endothelial Cells Exposed to Cyclic Strain in Vitro
Iba T, Sumpio B. Tissue Plasminogen Activator Expression in Endothelial Cells Exposed to Cyclic Strain in Vitro. Cell Transplantation 1992, 1: 43-50. PMID: 1285345, DOI: 10.1177/096368979200100108.Peer-Reviewed Original Research
1991
Stimulation of endothelial secretion of tissue-type plasminogen activator by repetitive stretch
Iba T, Shin T, Sonoda T, Rosales O, Sumpio B. Stimulation of endothelial secretion of tissue-type plasminogen activator by repetitive stretch. Journal Of Surgical Research 1991, 50: 457-460. PMID: 1903823, DOI: 10.1016/0022-4804(91)90024-g.Peer-Reviewed Original ResearchCells, CulturedEndothelium, VascularHumansOsmolar ConcentrationPhysical StimulationTime FactorsTissue Plasminogen Activator