2010
The Effects of Freezing versus Supercooling on Vascular Cells: Implications for Balloon Cryoplasty
Basco MT, Yiu WK, Cheng SW, Sumpio BE. The Effects of Freezing versus Supercooling on Vascular Cells: Implications for Balloon Cryoplasty. Journal Of Vascular And Interventional Radiology 2010, 21: 910-915. PMID: 20417120, PMCID: PMC2878641, DOI: 10.1016/j.jvir.2010.02.016.Peer-Reviewed Original Research
2008
Synergistic Effect of Cool/Thaw Cycles on Vascular Cells in an In Vitro Model of Cryoplasty
Yiu WK, Cheng SW, Sumpio BE. Synergistic Effect of Cool/Thaw Cycles on Vascular Cells in an In Vitro Model of Cryoplasty. Journal Of Vascular And Interventional Radiology 2008, 19: 925-930. PMID: 18503909, DOI: 10.1016/j.jvir.2008.02.007.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsAkt activationEndothelial cellsApoptotic smooth muscle cellsActivation of AktBovine aortic smooth muscle cellsAortic smooth muscle cellsSurvival responseDeoxynucleotidyl transferase-mediated dUTP nick end labelingFetal bovine serumTerminal deoxynucleotidyl transferase-mediated dUTP nick end labelingTransferase-mediated dUTP nick end labelingImmunoblot analysisDUTP nick end labelingHigher apoptotic rateVascular cells
2005
In–Vitro Model for Evaluation of the Effects of Supercooling and Re-warming on Vascular Cells
Yiu W, Aruny J, Cheng S, Sumpio B. In–Vitro Model for Evaluation of the Effects of Supercooling and Re-warming on Vascular Cells. International Journal Of Angiology 2005, 14: 237-241. DOI: 10.1007/s00547-005-2055-5.Peer-Reviewed Original ResearchInitial technical success rateEndothelial cellsRe-warming phasePeripheral vascular diseaseTransluminal balloon angioplastyRate of restenosisTechnical success rateTUNEL-positive cellsSmooth muscle cellsBalloon angioplastyVascular diseaseEndothelial cell survivalMuscle cellsVascular cellsVitro modelVessel wallSuccess rateUnderlying mechanismRestenosisCell survivalCellsCellular responsesCritical roleAngioplastyArtificial blood vessel: The Holy Grail of peripheral vascular surgery
Kakisis JD, Liapis CD, Breuer C, Sumpio BE. Artificial blood vessel: The Holy Grail of peripheral vascular surgery. Journal Of Vascular Surgery 2005, 41: 349-354. PMID: 15768021, DOI: 10.1016/j.jvs.2004.12.026.Peer-Reviewed Original ResearchConceptsVascular tissue engineeringArtificial vesselsIdeal vascular graftMechanical propertiesArtificial blood vesselsTissue engineeringBiodegradable polymersNative tissuePulsatile flowSmall intestine submucosaVascular graftsVivo environmentBioreactorVascular cellsPeripheral vascular surgeryInitial experimentsEngineeringPolymersFlowIn–Vitro model for evaluation of the effects of supercooling and re-warming on vascular cells
Yiu W, Aruny J, Cheng S, Sumpio B. In–Vitro model for evaluation of the effects of supercooling and re-warming on vascular cells. International Journal Of Angiology 2005, 237-241. DOI: 10.1055/s-0031-1276516.Peer-Reviewed Original ResearchInitial technical success rateEndothelial cellsRe-warming phasePeripheral vascular diseaseTransluminal balloon angioplastyRate of restenosisTechnical success rateTUNEL-positive cellsSmooth muscle cellsBalloon angioplastyVascular diseaseEndothelial cell survivalMuscle cellsVascular cellsVitro modelVessel wallSuccess rateUnderlying mechanismRestenosisCell survivalCellsCellular responsesCritical roleAngioplasty
2004
Molecular and biological effects of hemodynamics on vascular cells.
Pradhan S, Sumpio B. Molecular and biological effects of hemodynamics on vascular cells. Frontiers In Bioscience-Landmark 2004, 9: 3276-85. PMID: 15353357, DOI: 10.2741/1480.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisCell MovementCell ProliferationCells, CulturedCyclic AMPDiglyceridesDisease ProgressionEndothelial CellsExtracellular MatrixHemodynamicsHumansInositol 1,4,5-TrisphosphateIntercellular Adhesion Molecule-1Plasminogen ActivatorsProtein Kinase CRisk FactorsStress, MechanicalConceptsEndothelial cellsSignificant atherosclerotic plaqueSystemic risk factorsTissue plasminogen activatorCellular adhesion moleculesCurrent pertinent literatureCultured endothelial cellsRisk factorsSecond messenger systemsSignificant lesionsProtein kinase C pathwayICAM-1Atherosclerosis formationAtherosclerotic plaquesVascular anatomyKinase C pathwayNitric oxideVascular cellsPlasminogen activatorAdhesion moleculesBlood vesselsVascular biologyMessenger systemsVessel wallPertinent literatureCell signalling in vascular cells exposed to cyclic strain: the emerging role of protein phosphatases
Lee T, Sumpio BE. Cell signalling in vascular cells exposed to cyclic strain: the emerging role of protein phosphatases. Biotechnology And Applied Biochemistry 2004, 39: 129-139. PMID: 15032733, DOI: 10.1042/ba20030104.Peer-Reviewed Original ResearchConceptsPhosphorylation stateSerine/threonine residuesProtein phosphatase type 2AAbnormal phosphorylation stateCritical cellular functionsPhosphorylation of tyrosineRole of phosphatasesVascular cellsRole of proteinsThreonine residuesCellular functionsProtein kinaseIntracellular proteinsCellular growthHuman diseasesProteinPhosphataseType 2AEndothelial cellsCellsCardiac hypertrophyKinasePhosphorylationHaemodynamic forcesRole
2002
Photochemotherapy of vascular cells with 8‐methoxypsoralen and visible light: differential effects on endothelial and smooth muscle cells
Lee DM, Gasparro FP, Wang XJ, Kopec C, DeLeo K, Sumpio BE. Photochemotherapy of vascular cells with 8‐methoxypsoralen and visible light: differential effects on endothelial and smooth muscle cells. Photodermatology Photoimmunology & Photomedicine 2002, 18: 244-252. PMID: 12390666, DOI: 10.1034/j.1600-0781.2002.02770.x.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsEndothelial cellsPercutaneous transluminal coronary angioplastyMuscle cellsTransluminal coronary angioplastyLong-term efficacyAortic smooth muscle cellsBovine aortic smooth muscle cellsDose-dependent fashionReversible inhibitionCoronary angioplastyIntermediate doseLow doseHigh doseSMC proliferationCell countVascular cellsDoseProliferation of ECsEC proliferationDifferential effectsProliferationCellular migrationPresent studySignificant effect
1994
Signal transduction pathways in vascular cells exposed to cyclic strain
Sumpio B, Du W, Cohen C, Evans L, Isales C, Rosales O, Mills I. Signal transduction pathways in vascular cells exposed to cyclic strain. 1994, 3-22. DOI: 10.1017/cbo9780511629068.001.Peer-Reviewed Original Research