2000
Translocation of PKC isoforms in bovine aortic smooth muscle cells exposed to strain
Han O, Takei T, Basson M, Sumpio B. Translocation of PKC isoforms in bovine aortic smooth muscle cells exposed to strain. Journal Of Cellular Biochemistry 2000, 80: 367-372. PMID: 11135367, DOI: 10.1002/1097-4644(20010301)80:3<367::aid-jcb100>3.0.co;2-2.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsAortic smooth muscle cellsBovine aortic smooth muscle cellsMuscle cellsPKC-alphaPKC isoformsCyclic strain resultsCycles/minCytosolic fractionProliferation responseParticulate fractionNF-kappaBProtein kinase C activityCollagen type ICellular proliferationSignificant stimulationImmunoblotting analysisKinase C activityType IPKC activityC activityStimulationIndividual PKC isoformsIsoforms
1997
Strain activation of bovine aortic smooth muscle cell proliferation and alignment: Study of strain dependency and the role of protein kinase A and C signaling pathways
Mills I, Cohen C, Kamal K, Li G, Shin T, Du W, Sumpio B. Strain activation of bovine aortic smooth muscle cell proliferation and alignment: Study of strain dependency and the role of protein kinase A and C signaling pathways. Journal Of Cellular Physiology 1997, 170: 228-234. PMID: 9066778, DOI: 10.1002/(sici)1097-4652(199703)170:3<228::aid-jcp2>3.0.co;2-q.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 2Adenylyl CyclasesAnimalsAortaCattleCell DivisionCells, CulturedCyclic AMPCyclic AMP Response Element-Binding ProteinCyclic AMP-Dependent Protein KinasesEndothelium, VascularLeucine ZippersMuscle, Smooth, VascularProtein Kinase CSignal TransductionStress, MechanicalTranscription FactorsConceptsBovine aortic SMCSMC proliferationCAMP response elementAortic SMCsAC/cAMP/PKAAortic smooth muscle cell proliferationSmooth muscle cell proliferationProtein levelsCyclic AMP accumulationMuscle cell proliferationSmooth muscle cell phenotypeExposure of SMCAdenylate cyclase activityMuscle cell phenotypeAMP accumulationInhibition of PKACAMP/PKACyclic AMP pathwayMultifactorial natureProtein kinase C activityCyclase activityProtein kinase A (PKA) activityLack of involvementEnhanced proliferationCell proliferation