Featured Publications
Survival of the Fittest: Impact of Cardiorespiratory Fitness on Outcomes in Men and Women with Cardiovascular Disease
Safdar B, Mangi AA. Survival of the Fittest: Impact of Cardiorespiratory Fitness on Outcomes in Men and Women with Cardiovascular Disease. Clinical Therapeutics 2020, 42: 385-392. PMID: 32088022, DOI: 10.1016/j.clinthera.2020.01.014.Peer-Reviewed Original ResearchConceptsPeak cardiorespiratory fitnessCardiorespiratory fitnessCardiovascular diseaseCardiac rehabilitationPhysical inactivityMyocardial infarctionImpact of CRFOnset of CVDPeak exercise capacityCardiac rehabilitation programModifiable risk factorsRecurrent myocardial infarctionPoor functional outcomeCause of mortalitySex differencesImpact of sexCVD outcomesExercise capacityImproved survivalLow referralMale patientsFemale patientsExercise prescriptionFunctional outcomeRisk factorsChapter 6 Cardiovascular disease: Sex and gender evidence in acute ischemic syndrome and heart failure
Safdar B. Chapter 6 Cardiovascular disease: Sex and gender evidence in acute ischemic syndrome and heart failure. 2021, 101-127. DOI: 10.1016/b978-0-12-816569-0.00006-1.Peer-Reviewed Original ResearchCardiovascular diseaseHeart failureManagement of CVDAcute cardiovascular conditionsAcute ischemic syndromesCongestive heart failureIschemic heart diseasePrimary care practicesCause of mortalityIschemic syndromeCardiac remodelingHeart diseaseCardiovascular conditionsAutonomic regulationCare practicesClinical perspectiveGender evidenceSex differencesDiseaseSexHypertensionGenderObesityDiabetesFailure
2024
Sex differences in proteomics of cardiovascular disease: results from the Yale-CMD registry
Liu Y, Wang Z, Collins S, Testani J, Kleinstein S, Safdar B. Sex differences in proteomics of cardiovascular disease: results from the Yale-CMD registry. European Heart Journal 2024, 45: ehae666.3091. DOI: 10.1093/eurheartj/ehae666.3091.Peer-Reviewed Original ResearchCoronary microvascular dysfunctionCoronary artery diseaseUpregulation of lipidCardiovascular diseaseAcute heart failureCoronary artery disease cohortHistory of diabetesPathophysiology of CVDProximity extension assayBody mass indexSignificant sex differencesRegulation of blood flowSerum proteomic profilesSex differencesProteomic profilingAngiogenesis-related proteinsCardiac PET/CTHemodynamic instabilityIschemic symptomsMicrovascular dysfunctionFalse discovery rateHeart failureFebrile illnessFunctional pathway analysisMass index
2021
Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2
Wolfe J, Safdar B, Madsen TE, Sethuraman KN, Becker B, Greenberg MR, McGregor AJ. Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2. Clinical Therapeutics 2021, 43: 557-571.e1. PMID: 33583576, PMCID: PMC7833665, DOI: 10.1016/j.clinthera.2021.01.015.Peer-Reviewed Original ResearchConceptsImmunologic responseBody's immunologic responseCOVID-19 presentationComplications of infectionSARS-CoV-2Influence of hormonesGender-specific differencesClinical presentationLaboratory presentationOutcomesSex differencesSexBody responseInfectionTreatmentPresentationGender differencesResponseComplicationsDifferencesHormonePrevention
2020
Relationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences
Jelani Q, Mena‐Hurtado C, Burg M, Soufer R, Gosch K, Jones PG, Spertus JA, Safdar B, Smolderen KG. Relationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences. Journal Of The American Heart Association 2020, 9: e014583. PMID: 32781883, PMCID: PMC7660812, DOI: 10.1161/jaha.119.014583.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseDepressive symptomsHealth statusArtery diseaseEQ-5D visual analog scale scoresEQ-5D visual analog scaleVisual analog scale scoreGeneric health statusPeripheral Artery QuestionnaireVascular specialty clinicsAnalog scale scoreHealth status scoresPatient Health QuestionnaireSevere depressive symptomsVisual analog scaleHealth status outcomesWorse health statusAdjusted general linear modelSex differencesPORTRAIT registryPAD diagnosisPAD symptomsAnalog scaleConclusions WomenMean age
2015
Sex Differences in Reperfusion in Young Patients With ST-Segment–Elevation Myocardial Infarction
D'Onofrio G, Safdar B, Lichtman JH, Strait KM, Dreyer RP, Geda M, Spertus JA, Krumholz HM. Sex Differences in Reperfusion in Young Patients With ST-Segment–Elevation Myocardial Infarction. Circulation 2015, 131: 1324-1332. PMID: 25792558, PMCID: PMC4652789, DOI: 10.1161/circulationaha.114.012293.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionMyocardial infarctionReperfusion therapyAcute ST-segment elevation myocardial infarctionProspective observational cohort studyYoung AMI Patients (VIRGO) studyTime guidelinesYoung womenObservational cohort studyProportion of patientsElevation myocardial infarctionPercutaneous coronary interventionYears of ageSex differencesPatients 18Reperfusion strategyCohort studyCoronary interventionFibrinolytic therapyNeedle timeYounger patientsReperfusion delayRatio of womenReperfusion guidelinesSex disparities
2013
Focusing a Gender Lens on Emergency Medicine Research: 2012 Update
McGregor AJ, Greenberg M, Safdar B, Seigel T, Hendrickson R, Poznanski S, Davenport M, Miner J, Choo EK. Focusing a Gender Lens on Emergency Medicine Research: 2012 Update. Academic Emergency Medicine 2013, 20: 313-320. PMID: 23517266, DOI: 10.1111/acem.12085.Peer-Reviewed Original Research