Shock prediction with dipeptidyl peptidase-3 and renin (SPiDeR) in hypoxemic patients with COVID-19
Busse L, Teixeira J, Schaich C, Lohuis C, Nielsen N, Sturek J, Merck L, Self W, Puskarich M, Khan A, Semler M, Moskowitz A, Hager D, Duggal A, Rice T, Ginde A, Tiffany B, Iovine N, Chen P, Safdar B, Gibbs K, Javaheri A, de Wit M, Harkins M, Joly M, Collins S, Investigators F. Shock prediction with dipeptidyl peptidase-3 and renin (SPiDeR) in hypoxemic patients with COVID-19. Journal Of Critical Care 2024, 85: 154950. PMID: 39546997, DOI: 10.1016/j.jcrc.2024.154950.Peer-Reviewed Original ResearchRenin levelsVasopressor initiationAssociated with organ dysfunctionHigher 28-day mortalityVasopressor-free daysAssociated with increased riskBaseline plasma levelsAt-risk patientsOnset of shockAccelerating COVID-19 Therapeutic InterventionsVasopressor requirementsHypoxemic patientsAcute hypoxemiaOrgan dysfunctionBaseline hypotensionOdds ratioHypotensive eventsReninPlasma samplesPatientsTherapeutic interventionsHypoxemiaMortalityPlatform trialsBaseline