2024
Shock prediction with dipeptidyl peptidase-3 and renin (SPiDeR) in hypoxemic patients with COVID-19
Busse L, Teixeira J, Schaich C, Lohuis C, Nielsen N, Sturek J, Merck L, Self W, Puskarich M, Khan A, Semler M, Moskowitz A, Hager D, Duggal A, Rice T, Ginde A, Tiffany B, Iovine N, Chen P, Safdar B, Gibbs K, Javaheri A, de Wit M, Harkins M, Joly M, Collins S, Investigators F. Shock prediction with dipeptidyl peptidase-3 and renin (SPiDeR) in hypoxemic patients with COVID-19. Journal Of Critical Care 2024, 85: 154950. PMID: 39546997, DOI: 10.1016/j.jcrc.2024.154950.Peer-Reviewed Original ResearchRenin levelsVasopressor initiationAssociated with organ dysfunctionHigher 28-day mortalityVasopressor-free daysAssociated with increased riskBaseline plasma levelsAt-risk patientsOnset of shockAccelerating COVID-19 Therapeutic InterventionsVasopressor requirementsHypoxemic patientsAcute hypoxemiaOrgan dysfunctionBaseline hypotensionOdds ratioHypotensive eventsReninPlasma samplesPatientsTherapeutic interventionsHypoxemiaMortalityPlatform trialsBaseline
2023
Renin-Angiotensin System Modulation With Synthetic Angiotensin (1-7) and Angiotensin II Type 1 Receptor–Biased Ligand in Adults With COVID-19
Self W, Shotwell M, Gibbs K, de Wit M, Files D, Harkins M, Hudock K, Merck L, Moskowitz A, Apodaca K, Barksdale A, Safdar B, Javaheri A, Sturek J, Schrager H, Iovine N, Tiffany B, Douglas I, Levitt J, Busse L, Ginde A, Brown S, Hager D, Boyle K, Duggal A, Khan A, Lanspa M, Chen P, Puskarich M, Vonderhaar D, Venkateshaiah L, Gentile N, Rosenberg Y, Troendle J, Bistran-Hall A, DeClercq J, Lavieri R, Joly M, Orr M, Pulley J, Rice T, Schildcrout J, Semler M, Wang L, Bernard G, Collins S, Becker R, del Zoppo G, Henke P, Holubkov R, Johnson M, Kerr K, Lipman H, Lurie F, Pitt B, Vesely S, Fleg J, Aamodt D, Ayers J, Clark D, Collins J, Cook M, Dixon S, Graves J, Jordan C, Lindsell C, Lopez I, McKeel D, Orozco D, Prato N, Qi A, Qutab M, Stoughton C, Vermillion K, Walsh K, Winchell S, Young T, Franklin R, Wagner E, Walther T, Demitrack M, Johnson J, Walsh R, Bales B, Miller K, Torr D, Barot H, Landreth L, LaRose M, Parks L, Teixeira J, Cardenas S, Ceniceros J, Cunningham A, Kunkel S, Lovato D, Zimmerman B, Nguyen T, Zeger W, Nichols H, Wiedel N, Javaheri A, Stilinovic S, Brokowski C, Lu J, Solberg M, Lee D, Roach K, Tiffany B, Tanner C, Taylor A, Zumbahl J, Syed A, Mason J, Jackson P, Coleman R, Haughey H, Cherabuddi K, James N, Wakeman R, Duncan C, Montero C, Rogers A, Wilson J, Vojnik R, Perez C, Wyles D, Hiller T, Oakes J, Garcia A, Gong M, Mohamed A, Andrea L, Nair R, Nkemdirim W, Lopez B, Boujid S, Torres M, Garcia O, Martinez F, Baduashvili A, Bastman J, Chauhan L, Douin D, Finck L, Licursi A, ten Lohuis C, Zhang S, Bender W, Tovar S, Hayes S, Kurtzman N, Rosseto E, Scaffidi D, Shapiro N, Pak J, Allada G, Briceno G, Peña J, Oh M, Ali H, Beselman S, Eby Y, Klimov V, Hite R, Tanzeem H, Droege C, Winter J, Jackman S, Caudill A, Bayoumi E, Pascual E, Chen P, Mucha S, Thiruchelvam N, Siuba M, Mehkri O, Driver B, Hendrickson A, Kaus O, Ontiveros C, Riehm A, Laudun S, Hudock D, Ensley C, Shaner V, Gentile N, Isenberg D, Reimer H, Cincola P, Harris E, Callahan S, Yamane M, Barrios M, Desai N, Bharara A, Keller M, Majumder P, Dohe C, D’Armiento J, Goldklang M, Wagener G, Fonseca L, Valezquez-Sanchez I, Johnson N, Petersen E, Fuentes M, Newton M, Gundel S, Srinivasan V, Steel T, Robinson B. Renin-Angiotensin System Modulation With Synthetic Angiotensin (1-7) and Angiotensin II Type 1 Receptor–Biased Ligand in Adults With COVID-19. JAMA 2023, 329: 1170-1182. PMID: 37039791, PMCID: PMC10091180, DOI: 10.1001/jama.2023.3546.Peer-Reviewed Original ResearchConceptsAngiotensin II type 1 receptorII type 1 receptorRenin-angiotensin systemSevere COVID-19Type 1 receptorCause mortalityRAS agentsRAS modulationPlacebo groupAngiotensin IIIntravenous infusionOdds ratioSafety outcomesCOVID-19Renin-angiotensin system modulationSARS-CoV-2 infectionAcute COVID-19Key secondary outcomesAction of angiotensinKidney replacement therapySupplemental oxygen useCOVID-19 pathophysiologyContinuous intravenous infusionLast followSecondary outcomes
2021
Mild cognitive impairment in middle-aged adults with coronary microvascular dysfunction
Nowroozpoor A, Sharp E, Gordon R, Malicki C, Hwang U, Dziura J, D'Onofrio' G, Safdar B. Mild cognitive impairment in middle-aged adults with coronary microvascular dysfunction. European Heart Journal 2021, 42: ehab724.2744. DOI: 10.1093/eurheartj/ehab724.2744.Peer-Reviewed Original ResearchCoronary microvascular dysfunctionCoronary flow reservePerfusion defectsCognitive impairmentMean ageCMD patientsCardiac positron emission tomography/Chest pain observation unitPositron emission tomography/Coronary artery diseaseSmall vessel diseaseEmission tomography/Montreal Cognitive AssessmentChest discomfortHypertensive urgencyMicrovascular dysfunctionArtery diseaseHeart failureVessel diseaseMyocardial infarctionTomography/Odds ratioFlow reserveNormal groupYears of education
2011
Inclusion of Gender in Emergency Medicine Research
Safdar B, McGregor AJ, McKee SA, Ali A, Radulescu R, Himelfarb NT, Klein MR, Mazure CM. Inclusion of Gender in Emergency Medicine Research. Academic Emergency Medicine 2011, 18: e1-e4. PMID: 21314767, DOI: 10.1111/j.1553-2712.2010.00978.x.Peer-Reviewed Original ResearchConceptsHealth outcomesEmergency departmentOdds ratioEmergency medicineConfidence intervalsEffect of genderPrimary hypothesisEmergency medical servicesGender-specific approachEmergency medicine researchAcute settingAdult human subjectsCardiovascular diseaseEmergency physiciansEmergency careManagement of diseasesStudy subjectsClinical specialistsPatient careStudy designStudy periodChi-squareMedical servicesOutcomesHuman subjects