Featured Publications
Survival of the Fittest: Impact of Cardiorespiratory Fitness on Outcomes in Men and Women with Cardiovascular Disease
Safdar B, Mangi AA. Survival of the Fittest: Impact of Cardiorespiratory Fitness on Outcomes in Men and Women with Cardiovascular Disease. Clinical Therapeutics 2020, 42: 385-392. PMID: 32088022, DOI: 10.1016/j.clinthera.2020.01.014.Peer-Reviewed Original ResearchConceptsPeak cardiorespiratory fitnessCardiorespiratory fitnessCardiovascular diseaseCardiac rehabilitationPhysical inactivityMyocardial infarctionImpact of CRFOnset of CVDPeak exercise capacityCardiac rehabilitation programModifiable risk factorsRecurrent myocardial infarctionPoor functional outcomeCause of mortalitySex differencesImpact of sexCVD outcomesExercise capacityImproved survivalLow referralMale patientsFemale patientsExercise prescriptionFunctional outcomeRisk factorsChapter 6 Cardiovascular disease: Sex and gender evidence in acute ischemic syndrome and heart failure
Safdar B. Chapter 6 Cardiovascular disease: Sex and gender evidence in acute ischemic syndrome and heart failure. 2021, 101-127. DOI: 10.1016/b978-0-12-816569-0.00006-1.Peer-Reviewed Original ResearchCardiovascular diseaseHeart failureManagement of CVDAcute cardiovascular conditionsAcute ischemic syndromesCongestive heart failureIschemic heart diseasePrimary care practicesCause of mortalityIschemic syndromeCardiac remodelingHeart diseaseCardiovascular conditionsAutonomic regulationCare practicesClinical perspectiveGender evidenceSex differencesDiseaseSexHypertensionGenderObesityDiabetesFailure
2024
Sex differences in proteomics of cardiovascular disease: results from the Yale-CMD registry
Liu Y, Wang Z, Collins S, Testani J, Kleinstein S, Safdar B. Sex differences in proteomics of cardiovascular disease: results from the Yale-CMD registry. European Heart Journal 2024, 45: ehae666.3091. DOI: 10.1093/eurheartj/ehae666.3091.Peer-Reviewed Original ResearchCoronary microvascular dysfunctionCoronary artery diseaseUpregulation of lipidCardiovascular diseaseAcute heart failureCoronary artery disease cohortHistory of diabetesPathophysiology of CVDProximity extension assayBody mass indexSignificant sex differencesRegulation of blood flowSerum proteomic profilesSex differencesProteomic profilingAngiogenesis-related proteinsCardiac PET/CTHemodynamic instabilityIschemic symptomsMicrovascular dysfunctionFalse discovery rateHeart failureFebrile illnessFunctional pathway analysisMass index
2023
Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging
de Havenon A, Parasuram N, Crawford A, Mazurek M, Chavva I, Yadlapalli V, Iglesias J, Rosen M, Falcone G, Payabvash S, Sze G, Sharma R, Schiff S, Safdar B, Wira C, Kimberly W, Sheth K. Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging. Journal Of The American Heart Association 2023, 12: e029242. PMID: 37218590, PMCID: PMC10381997, DOI: 10.1161/jaha.122.029242.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesMagnetic resonance imagingSevere white matter hyperintensitiesConventional magnetic resonance imagingResonance imagingRetrospective cohortEmergency departmentMatter hyperintensitiesVascular risk factorsProspective observational studyVascular cognitive impairmentTesla magnetic resonance imagingArea Deprivation IndexProspective cohortAdult patientsAcute careRisk factorsCardiovascular diseaseObservational studyCognitive impairmentPatientsCare magnetic resonance imagingIntermodality agreementCohortDeprivation indexAppraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Heart Association
Alexander B, South A, August P, Bertagnolli M, Ferranti E, Grobe J, Jones E, Loria A, Safdar B, Sequeira-Lopez M, Health O. Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Heart Association. Hypertension 2023, 80: e75-e89. PMID: 36951054, PMCID: PMC10242542, DOI: 10.1161/hyp.0000000000000227.Peer-Reviewed Original ResearchConceptsAldosterone systemCardiovascular healthCardiovascular diseaseLong-term cardiovascular healthAntenatal risk factorsRisk of hypertensionAdverse cardiovascular healthAmerican Heart AssociationMaternal-fetal healthTranslational research studiesPregnancy complicationsRenin-AngiotensinPreclinical evidenceComplicated pregnanciesPlacental interfaceHeart AssociationRisk factorsSystem dysregulationNovel therapiesClinical careRisk individualsHealth outcomesLife courseDiseaseScientific evidence
2020
Cardiovascular Considerations in Caring for Pregnant Patients: A Scientific Statement From the American Heart Association
Mehta LS, Warnes CA, Bradley E, Burton T, Economy K, Mehran R, Safdar B, Sharma G, Wood M, Valente AM, Volgman A, Council O. Cardiovascular Considerations in Caring for Pregnant Patients: A Scientific Statement From the American Heart Association. Circulation 2020, 141: e884-e903. PMID: 32362133, DOI: 10.1161/cir.0000000000000772.Peer-Reviewed Original ResearchConceptsCardio-obstetrics teamCardiovascular diseaseCardiac conditionsMultidisciplinary cardio-obstetrics teamHistory of preeclampsiaPregnancy-related mortalityPrimary care cliniciansAmerican Heart AssociationScientific statementHypertensive disordersMaternal morbidityPregnant patientsPreconception counselingValvular diseaseCare cliniciansComorbid conditionsThromboembolic diseaseAortic diseaseCardiovascular ConsiderationsCerebrovascular diseaseYear postpartumHeart AssociationMaternal mortalityMaternal ageMyocardial infarction
2011
Inclusion of Gender in Emergency Medicine Research
Safdar B, McGregor AJ, McKee SA, Ali A, Radulescu R, Himelfarb NT, Klein MR, Mazure CM. Inclusion of Gender in Emergency Medicine Research. Academic Emergency Medicine 2011, 18: e1-e4. PMID: 21314767, DOI: 10.1111/j.1553-2712.2010.00978.x.Peer-Reviewed Original ResearchConceptsHealth outcomesEmergency departmentOdds ratioEmergency medicineConfidence intervalsEffect of genderPrimary hypothesisEmergency medical servicesGender-specific approachEmergency medicine researchAcute settingAdult human subjectsCardiovascular diseaseEmergency physiciansEmergency careManagement of diseasesStudy subjectsClinical specialistsPatient careStudy designStudy periodChi-squareMedical servicesOutcomesHuman subjects