2023
Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations
Ren J, Qu R, Rahman N, Lewis J, King A, Liao X, Mirza F, Carlson K, Huang Y, Gigante S, Evans B, Rajendran B, Xu S, Wang G, Foss F, Damsky W, Kluger Y, Krishnaswamy S, Girardi M. Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations. Blood Advances 2023, 7: 445-457. PMID: 35947128, PMCID: PMC9979716, DOI: 10.1182/bloodadvances.2022008168.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaMalignant CTCL cellsDiverse transcriptomic profilesT cellsSingle-cell RNACTCL cellsDevelopment of CTCLIntegrated transcriptomeT-cell receptor sequencingT cell exhaustion phenotypeCommon antigenic stimulusPeripheral blood CD4Transcriptomic profilesGene expressionT-cell lymphomaIntegrative analysisPotential therapeutic targetProliferation advantageLimited diversityBlood CD4Blood involvementMutation levelsExhaustion phenotypeWorse prognosisAntigenic stimulus
2017
comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis
Rajendran B, Deng C. comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis. Oncotarget 2017, 5: 102263-102276. PMID: 29254242, PMCID: PMC5731952, DOI: 10.18632/oncotarget.20404.Peer-Reviewed Original ResearchCopy number alterationsBreast tumorigenesisNumber alterationsGenetic network analysisPrognostic molecular signaturesCancer-associated genesCellular functionsOBSCN geneMultifunctional proteinBreast cancer progressionMyofibril organizationClinical breast cancer samplesGene expressionIntegrative analysisFunctional mutationsDownstream pathwaysExpression dataGenesCell adhesionMolecular signaturesCancer progressionGene methylationDirect roleTumorigenesisObscurin