2021
Reduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination
Tozzi L, Zhang X, Chesnut M, Holt-Gosselin B, Ramirez CA, Williams LM. Reduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination. NeuroImage Clinical 2021, 30: 102570. PMID: 33540370, PMCID: PMC7856327, DOI: 10.1016/j.nicl.2021.102570.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDefault mode networkFunctional connectivityDMPFC subsystemResting-state functional connectivity changesDiagnosis of MDDDMN subsystemsDiagnostic categoriesDefault mode network subsystemsResting-state functional connectivityFunctional connectivity changesDorsal medial prefrontal cortex (dMPFC) subsystemAnxiety/depressionMedial temporal lobe (MTL) subsystemSubgroup of individualsIllness durationDepressive disorderPrognostic markerDMN connectivityUnmedicated participantsConnectivity changesMidline coreMode networkMeta-analytic evidenceSymptoms
2020
The human connectome project for disordered emotional states: Protocol and rationale for a research domain criteria study of brain connectivity in young adult anxiety and depression
Tozzi L, Staveland B, Holt-Gosselin B, Chesnut M, Chang SE, Choi D, Shiner M, Wu H, Lerma-Usabiaga G, Sporns O, Barch DM, Gotlib IH, Hastie TJ, Kerr AB, Poldrack RA, Wandell BA, Wintermark M, Williams LM. The human connectome project for disordered emotional states: Protocol and rationale for a research domain criteria study of brain connectivity in young adult anxiety and depression. NeuroImage 2020, 214: 116715. PMID: 32147367, PMCID: PMC8597395, DOI: 10.1016/j.neuroimage.2020.116715.Peer-Reviewed Original ResearchMeSH KeywordsAffective SymptomsAnxietyBrainConnectomeDepressionFemaleHumansMagnetic Resonance ImagingMaleNerve NetNeural PathwaysYoung AdultConceptsHuman Connectome ProjectBilateral dorsolateral prefrontalEmotional statesConnectome dysfunctionsDorsolateral prefrontalPositive Valence Systems domainConnectome ProjectResearch Domain Criteria (RDoC) initiativeCognitive systems domainNegative Valence Systems domainFunctional magnetic resonance imagingNegative emotional facesOccipital cortexPositive emotional experiencesYoung adult anxietyForms of psychopathologyConstructs of interestMultiple diagnostic categoriesEmotional facesCognitive controlNegative emotionsNeurobiological modelsEmotional experienceFusiform gyrusSelf-reported symptoms