2022
Intrinsic Connectivity and Family Dynamics: Striatolimbic Markers of Risk and Resilience in Youth at Familial Risk for Mood Disorders
Fischer AS, Holt-Gosselin B, Hagan KE, Fleming SL, Nimarko AF, Gotlib IH, Singh MK. Intrinsic Connectivity and Family Dynamics: Striatolimbic Markers of Risk and Resilience in Youth at Familial Risk for Mood Disorders. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 855-866. PMID: 35272095, PMCID: PMC9452604, DOI: 10.1016/j.bpsc.2022.02.009.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentDepressive Disorder, MajorFamily RelationsGenetic Predisposition to DiseaseHumansMagnetic Resonance ImagingMood DisordersConceptsLow-risk youthMood disordersFunctional connectivityFamilial riskFC differencesFC relativeRisk statusMajor depressive disorderHigh familial riskDepressive disorderMore effective interventionsBipolar disorderNovel interventionsIntrinsic connectivityEffective interventionsFrontal gyrusDisordersRiskGyrusPsychopathologyFamily rigidityNeural underpinningsInterventionNeural signaturesFamily dynamics
2021
Greater baseline connectivity of the salience and negative affect circuits are associated with natural improvements in anxiety over time in untreated participants
Holt-Gosselin B, Keller AS, Chesnut M, Ling R, Grisanzio KA, Williams LM. Greater baseline connectivity of the salience and negative affect circuits are associated with natural improvements in anxiety over time in untreated participants. Journal Of Affective Disorders 2021, 295: 366-376. PMID: 34492429, DOI: 10.1016/j.jad.2021.08.039.Peer-Reviewed Original ResearchConceptsAnxiety symptom improvementNegative affect circuitSymptoms of anxietyCognitive controlSymptom improvementSad facesLifestyle activitiesPositive affectBehavioral therapyCircuit connectivityBaseline connectivityDefault modeRight insulaPsychosocial functionSocial interactionAnxiety improvementActivity engagementDepression symptomsAnxietySalienceNeural circuit functionNatural improvementUntreated participantsCausal inferenceLimited researchReduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination
Tozzi L, Zhang X, Chesnut M, Holt-Gosselin B, Ramirez CA, Williams LM. Reduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination. NeuroImage Clinical 2021, 30: 102570. PMID: 33540370, PMCID: PMC7856327, DOI: 10.1016/j.nicl.2021.102570.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain MappingDefault Mode NetworkDepressionDepressive Disorder, MajorHumansMagnetic Resonance ImagingNerve NetNeural PathwaysConceptsMajor depressive disorderDefault mode networkFunctional connectivityDMPFC subsystemResting-state functional connectivity changesDiagnosis of MDDDMN subsystemsDiagnostic categoriesDefault mode network subsystemsResting-state functional connectivityFunctional connectivity changesDorsal medial prefrontal cortex (dMPFC) subsystemAnxiety/depressionMedial temporal lobe (MTL) subsystemSubgroup of individualsIllness durationDepressive disorderPrognostic markerDMN connectivityUnmedicated participantsConnectivity changesMidline coreMode networkMeta-analytic evidenceSymptoms
2020
Intrinsic reward circuit connectivity profiles underlying symptom and quality of life outcomes following antidepressant medication: a report from the iSPOT-D trial
Fischer AS, Holt-Gosselin B, Fleming SL, Hack LM, Ball TM, Schatzberg AF, Williams LM. Intrinsic reward circuit connectivity profiles underlying symptom and quality of life outcomes following antidepressant medication: a report from the iSPOT-D trial. Neuropsychopharmacology 2020, 46: 809-819. PMID: 33230268, PMCID: PMC8027440, DOI: 10.1038/s41386-020-00905-3.Peer-Reviewed Original ResearchMeSH KeywordsAntidepressive AgentsCitalopramDepressive Disorder, MajorHumansMagnetic Resonance ImagingQuality of LifeRewardConceptsMajor depressive disorderISPOT-D TrialReward neurocircuitryFunctional connectivitySymptom respondersQOL responsesAntidepressant medication responseFC relativeQuality of lifeSame time pointsNeural basisAntidepressant medicationVenlafaxine XRSymptom responseDepressive disorderHealthy controlsMedication responseSymptom alleviationADM treatmentADM responsesLife outcomesNeurocircuitrySymptomsTime pointsConnectivity profilesThe human connectome project for disordered emotional states: Protocol and rationale for a research domain criteria study of brain connectivity in young adult anxiety and depression
Tozzi L, Staveland B, Holt-Gosselin B, Chesnut M, Chang SE, Choi D, Shiner M, Wu H, Lerma-Usabiaga G, Sporns O, Barch DM, Gotlib IH, Hastie TJ, Kerr AB, Poldrack RA, Wandell BA, Wintermark M, Williams LM. The human connectome project for disordered emotional states: Protocol and rationale for a research domain criteria study of brain connectivity in young adult anxiety and depression. NeuroImage 2020, 214: 116715. PMID: 32147367, PMCID: PMC8597395, DOI: 10.1016/j.neuroimage.2020.116715.Peer-Reviewed Original ResearchMeSH KeywordsAffective SymptomsAnxietyBrainConnectomeDepressionFemaleHumansMagnetic Resonance ImagingMaleNerve NetNeural PathwaysYoung AdultConceptsHuman Connectome ProjectBilateral dorsolateral prefrontalEmotional statesConnectome dysfunctionsDorsolateral prefrontalPositive Valence Systems domainConnectome ProjectResearch Domain Criteria (RDoC) initiativeCognitive systems domainNegative Valence Systems domainFunctional magnetic resonance imagingNegative emotional facesOccipital cortexPositive emotional experiencesYoung adult anxietyForms of psychopathologyConstructs of interestMultiple diagnostic categoriesEmotional facesCognitive controlNegative emotionsNeurobiological modelsEmotional experienceFusiform gyrusSelf-reported symptoms