2021
Reduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination
Tozzi L, Zhang X, Chesnut M, Holt-Gosselin B, Ramirez CA, Williams LM. Reduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination. NeuroImage Clinical 2021, 30: 102570. PMID: 33540370, PMCID: PMC7856327, DOI: 10.1016/j.nicl.2021.102570.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDefault mode networkFunctional connectivityDMPFC subsystemResting-state functional connectivity changesDiagnosis of MDDDMN subsystemsDiagnostic categoriesDefault mode network subsystemsResting-state functional connectivityFunctional connectivity changesDorsal medial prefrontal cortex (dMPFC) subsystemAnxiety/depressionMedial temporal lobe (MTL) subsystemSubgroup of individualsIllness durationDepressive disorderPrognostic markerDMN connectivityUnmedicated participantsConnectivity changesMidline coreMode networkMeta-analytic evidenceSymptoms
2019
Integrating sleep, neuroimaging, and computational approaches for precision psychiatry
Goldstein-Piekarski AN, Holt-Gosselin B, O’Hora K, Williams LM. Integrating sleep, neuroimaging, and computational approaches for precision psychiatry. Neuropsychopharmacology 2019, 45: 192-204. PMID: 31426055, PMCID: PMC6879628, DOI: 10.1038/s41386-019-0483-8.Peer-Reviewed Original ResearchConceptsSleep impairmentAnxiety disordersBrain circuit dysfunctionPrecision psychiatryLarge-scale neural circuitsDefault mode networkMode networkAffective networkPoor sleep qualityExplanatory roleDistal featuresMood symptomsMoodNetwork dysfunctionSleep qualityNeural circuitsSleep disturbancesTestable frameworkCircuit dysfunctionImpairmentPersonalized tailoringDigital phenotypingFuture directionsMachine learning approachesCurrent diagnostic criteria