2022
Intrinsic Connectivity and Family Dynamics: Striatolimbic Markers of Risk and Resilience in Youth at Familial Risk for Mood Disorders
Fischer AS, Holt-Gosselin B, Hagan KE, Fleming SL, Nimarko AF, Gotlib IH, Singh MK. Intrinsic Connectivity and Family Dynamics: Striatolimbic Markers of Risk and Resilience in Youth at Familial Risk for Mood Disorders. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 855-866. PMID: 35272095, PMCID: PMC9452604, DOI: 10.1016/j.bpsc.2022.02.009.Peer-Reviewed Original ResearchConceptsLow-risk youthMood disordersFunctional connectivityFamilial riskFC differencesFC relativeRisk statusMajor depressive disorderHigh familial riskDepressive disorderMore effective interventionsBipolar disorderNovel interventionsIntrinsic connectivityEffective interventionsFrontal gyrusDisordersRiskGyrusPsychopathologyFamily rigidityNeural underpinningsInterventionNeural signaturesFamily dynamics
2021
Reduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination
Tozzi L, Zhang X, Chesnut M, Holt-Gosselin B, Ramirez CA, Williams LM. Reduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination. NeuroImage Clinical 2021, 30: 102570. PMID: 33540370, PMCID: PMC7856327, DOI: 10.1016/j.nicl.2021.102570.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDefault mode networkFunctional connectivityDMPFC subsystemResting-state functional connectivity changesDiagnosis of MDDDMN subsystemsDiagnostic categoriesDefault mode network subsystemsResting-state functional connectivityFunctional connectivity changesDorsal medial prefrontal cortex (dMPFC) subsystemAnxiety/depressionMedial temporal lobe (MTL) subsystemSubgroup of individualsIllness durationDepressive disorderPrognostic markerDMN connectivityUnmedicated participantsConnectivity changesMidline coreMode networkMeta-analytic evidenceSymptoms
2020
Intrinsic reward circuit connectivity profiles underlying symptom and quality of life outcomes following antidepressant medication: a report from the iSPOT-D trial
Fischer AS, Holt-Gosselin B, Fleming SL, Hack LM, Ball TM, Schatzberg AF, Williams LM. Intrinsic reward circuit connectivity profiles underlying symptom and quality of life outcomes following antidepressant medication: a report from the iSPOT-D trial. Neuropsychopharmacology 2020, 46: 809-819. PMID: 33230268, PMCID: PMC8027440, DOI: 10.1038/s41386-020-00905-3.Peer-Reviewed Original ResearchConceptsMajor depressive disorderISPOT-D TrialReward neurocircuitryFunctional connectivitySymptom respondersQOL responsesAntidepressant medication responseFC relativeQuality of lifeSame time pointsNeural basisAntidepressant medicationVenlafaxine XRSymptom responseDepressive disorderHealthy controlsMedication responseSymptom alleviationADM treatmentADM responsesLife outcomesNeurocircuitrySymptomsTime pointsConnectivity profiles