2024
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety
Tozzi L, Zhang X, Pines A, Olmsted A, Zhai E, Anene E, Chesnut M, Holt-Gosselin B, Chang S, Stetz P, Ramirez C, Hack L, Korgaonkar M, Wintermark M, Gotlib I, Ma J, Williams L. Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety. Nature Medicine 2024, 30: 2076-2087. PMID: 38886626, PMCID: PMC11271415, DOI: 10.1038/s41591-024-03057-9.Peer-Reviewed Original ResearchBehavioral therapyFunctional magnetic resonance imaging protocolTask-free functional connectivityHeterogeneity of depressionBrain circuit dysfunctionResponse to pharmacotherapyTheoretical taxonomyAttentional circuitsNeurobiological dysfunctionBehavioral performanceCircuit dysfunctionCognitive tasksSubcortical regionsFunctional connectivityTask-freeAnxietyDepressionTheory-drivenPharmacotherapyStratification of patientsMagnetic resonance imaging protocolScoresPsychiatryDysfunctionClinical care
2021
Greater baseline connectivity of the salience and negative affect circuits are associated with natural improvements in anxiety over time in untreated participants
Holt-Gosselin B, Keller AS, Chesnut M, Ling R, Grisanzio KA, Williams LM. Greater baseline connectivity of the salience and negative affect circuits are associated with natural improvements in anxiety over time in untreated participants. Journal Of Affective Disorders 2021, 295: 366-376. PMID: 34492429, DOI: 10.1016/j.jad.2021.08.039.Peer-Reviewed Original ResearchConceptsAnxiety symptom improvementNegative affect circuitSymptoms of anxietyCognitive controlSymptom improvementSad facesLifestyle activitiesPositive affectBehavioral therapyCircuit connectivityBaseline connectivityDefault modeRight insulaPsychosocial functionSocial interactionAnxiety improvementActivity engagementDepression symptomsAnxietySalienceNeural circuit functionNatural improvementUntreated participantsCausal inferenceLimited researchMapping Neural Circuit Biotypes to Symptoms and Behavioral Dimensions of Depression and Anxiety
Goldstein-Piekarski AN, Ball TM, Samara Z, Staveland BR, Keller AS, Fleming SL, Grisanzio KA, Holt-Gosselin B, Stetz P, Ma J, Williams LM. Mapping Neural Circuit Biotypes to Symptoms and Behavioral Dimensions of Depression and Anxiety. Biological Psychiatry 2021, 91: 561-571. PMID: 34482948, PMCID: PMC9511971, DOI: 10.1016/j.biopsych.2021.06.024.Peer-Reviewed Original ResearchConceptsCognitive controlAnxious avoidanceTransdiagnostic symptomsCognitive functionAnxiety disordersAffective circuitsBehavioral dimensionsLoss of pleasurePoorer daily functionBrain circuitsEmotional functionAnxietyNeural circuitsIndependent samplesHealthy reference sampleHuman neural circuitsTreatment targetsDepressionDaily functionIndividual patient levelCircuit assessmentCircuit definitionIntervention treatmentDysfunction scoreClinical scoresCoping Strategies, Neural Structure, and Depression and Anxiety During the COVID-19 Pandemic: A Longitudinal Study in a Naturalistic Sample Spanning Clinical Diagnoses and Subclinical Symptoms
Holt-Gosselin B, Tozzi L, Ramirez CA, Gotlib IH, Williams LM. Coping Strategies, Neural Structure, and Depression and Anxiety During the COVID-19 Pandemic: A Longitudinal Study in a Naturalistic Sample Spanning Clinical Diagnoses and Subclinical Symptoms. Biological Psychiatry Global Open Science 2021, 1: 261-271. PMID: 34604834, PMCID: PMC8479487, DOI: 10.1016/j.bpsgos.2021.06.007.Peer-Reviewed Original ResearchAnxious arousal symptomsMaladaptive coping strategiesArousal symptomsCoping strategiesSubclinical symptomsBrain regionsNeural structuresGray matter volumePreregistered hypothesesNeural factorsAnhedonia symptomsStressful eventsDepression symptomsGeneral linear mixed-effects modelsNaturalistic sampleLongitudinal studyMatter volumeAmygdala volumeAnxietyLower structural integrityCOVID-19 pandemicT1-weighted scansCortical thicknessPsychiatric diagnosisClinical symptoms