2023
Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve
Ahmad A, Ghim M, Toczek J, Neishabouri A, Ojha D, Zhang Z, Gona K, Raza M, Jung J, Kukreja G, Zhang J, Guerrera N, Liu C, Sadeghi M. Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve. Journal Of Nuclear Medicine 2023, 64: 1487-1494. PMID: 37321825, PMCID: PMC10478817, DOI: 10.2967/jnumed.123.265516.Peer-Reviewed Original ResearchConceptsF-NaF PET/CTCalcific aortic valve diseaseBicuspid aortic valvePET/CTAortic valve calcificationAortic valve diseaseAortic valveAortic stenosisValve calcificationValvular calcificationValve diseaseF-NaFSubset of miceTricuspid aortic valveDevelopment of calcificationSignificant correlationUnderwent echocardiographyMedical therapyHigh prevalencePreclinical modelsMurine modelTherapeutic interventionsAge groupsAutoradiography dataMultimodality imagingPositron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm
Toczek J, Gona K, Liu Y, Ahmad A, Ghim M, Ojha D, Kukreja G, Salarian M, Luehmann H, Heo G, Guzman R, Chaar C, Tellides G, Hassab A, Ye Y, Shoghi K, Zayed M, Gropler R, Sadeghi M. Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2023, 16: e014615. PMID: 36649454, PMCID: PMC9858355, DOI: 10.1161/circimaging.122.014615.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmHuman aortic tissueMMP activityAortic tissueAortic aneurysmMMP inhibitorsMurine modelMatrix metalloproteinasesPositron emission tomography/Toxicology studiesAortic MMP activityPositron emission tomography radioligandAngiotensin II infusionEmission tomography/Murine abdominal aortic aneurysmsBroad-spectrum MMP inhibitorMatrix metalloproteinase activityPositron emission tomography (PET) tracerPositron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyEmission tomography tracerII infusionRisk stratificationTomography/
2020
Location and function of transient receptor potential canonical channel 1 in ventricular myocytes
Hu Q, Ahmad A, Seidel T, Hunter C, Streiff M, Nikolova L, Spitzer K, Sachse F. Location and function of transient receptor potential canonical channel 1 in ventricular myocytes. Journal Of Molecular And Cellular Cardiology 2020, 139: 113-123. PMID: 31982426, PMCID: PMC7085981, DOI: 10.1016/j.yjmcc.2020.01.008.Peer-Reviewed Original ResearchConceptsNeonatal rat ventricular myocytesRabbit ventricular myocytesVentricular myocytesSarcoplasmic reticulumChannel blocker SKF-96365TRPC1 overexpressionTransient receptor potential canonical channel 1Physiological pacing ratesTRPC1 channelsAdult rabbit ventricular myocytesRole of TRPC1Rat ventricular myocytesSarco/endoplasmic reticulum CaTransient receptor potentialMammalian ventricular myocytesIsolated rabbit cardiomyocytesEndoplasmic reticulum CaSKF-96365Free solutionCardiac hypertrophyPacing rateAction potentialsTRPC channelsTransverse tubular systemReticulum Ca
2017
Physiological and pathophysiological role of transient receptor potential canonical channels in cardiac myocytes
Ahmad A, Streiff M, Hunter C, Hu Q, Sachse F. Physiological and pathophysiological role of transient receptor potential canonical channels in cardiac myocytes. Progress In Biophysics And Molecular Biology 2017, 130: 254-263. PMID: 28629808, DOI: 10.1016/j.pbiomolbio.2017.06.005.Peer-Reviewed Original ResearchConceptsTransient receptor potential canonical (TRPC) channelsTRPC channelsCanonical channelsHypertrophic signalingCardiac pathophysiologyPhysiological rolePermeable ion channelsNon-cardiac cellsPathophysiological roleCardiac diseaseHeart rateTopic of controversyTRPC activityPharmacological toolsSuggested physiological rolesCardiac physiologyCardiac myocytesMammalian heartCardiac cellsPathophysiologyPrecise roleTRPC1HeartIon channelsCell types