Azmi Ahmad, PhD
Postdoctoral AssociateAbout
Titles
Postdoctoral Associate
Biography
Azmi A Ahmad, PhD, is a postdoctoral fellow at the Yale School of Medicine – Internal Medicine, working in the Cardiovascular Molecular Imaging Laboratory. Dr. Ahmad received his B.Sc. and Ph.D. in Biomedical Engineering from Union College and the University of Utah, respectively. His graduate research focused on electrophysiology and biophysics, where he investigated calcium signaling and SR leak in cardiomyocytes. His current research and training, under the mentorship of Dr. Mehran Sadeghi, focuses on translational research using molecular imaging to develop in vivo approaches to characterize calcific aortic valve disease and assess novel therapies. The work additionally utilizes novel tracers for molecular imaging of cardiac remodeling in various other disease models. Dr. Ahmad's postdoctoral work is funded by an NIH-T32 grant that utilizes multi-modality imaging, such as PET/CT, to detect calcification in a murine model of CAVD. He has presented his work at several conferences, and the work received the Young Investigator Award for Best Basic-Technical Abstract at the American Society of Nuclear Cardiology (ASNC) 26th Annual Scientific Session and Exhibition.
Dr. Ahmad has established leadership experience in the postdoctoral community as Advocacy Committee Coordinator at the Yale Postdoctoral Association (YPA), as well as Outreach Chair and Co-Chair at the Yale Black Postdoctoral Association (YBPA), with an additional track record of volunteering to uplift and support underrepresented minorities. At the YPA, he organized events to promote mental health and mental health first aid training, mindfulness events, as well as postdoc appreciation and recognition events for promoting work-life balance. At the YBPA, he helps build a community for Black postdocs and allies, as well as giving back to the New Haven community through volunteer efforts at the food pantry and fundraising for the unhoused community. Most recently, he has been elected to serve on the National Postdoctoral Association’s (NPA) Postdoc Council and also serves as the Vice-Chair of the NPA’s Advocacy Committee. Dr. Ahmad has been invited to give several talks on his advocacy efforts and strategies at scientific societies such as Association of American Medical Colleges (AAMC) and National Science Policy Network (NSPN).
Dr. Ahmad continues to advocate for young scholars to feel safe to engage in respectful discussion without harassment and animus to create a diverse, inclusive, and supportive community.
Departments & Organizations
- Internal Medicine
- Sadeghi Lab
- Yale Black Postdoc Association (YBPA)
Research
Overview
Public Health Interests
ORCID
0000-0003-0326-440X- View Lab Website
Lab Website
Research at a Glance
Yale Co-Authors
Publications Timeline
Gunjan Kukreja, PhD, MSc
Mean Ghim, PhD
Mehran M Sadeghi, MD
Jiasheng Zhang, MD
Chi Liu, PhD
George Tellides, MD, PhD
Publications
2024
Molecular Imaging of Collagen Turnover in Myocardial Infarction
Neishabouri A, Ghim M, Ahmad A, Kukreja G, Zhang Z, Li J, Salarian M, Toczek J, Gona K, Hedayatyanfard K, Zhang J, Huang H, Yu S, Sadeghi M. Molecular Imaging of Collagen Turnover in Myocardial Infarction. Journal Of Nuclear Cardiology 2024, 38: 101998. DOI: 10.1016/j.nuclcard.2024.101998.Peer-Reviewed Original Research
2023
Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve
Ahmad A, Ghim M, Toczek J, Neishabouri A, Ojha D, Zhang Z, Gona K, Raza M, Jung J, Kukreja G, Zhang J, Guerrera N, Liu C, Sadeghi M. Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve. Journal Of Nuclear Medicine 2023, 64: 1487-1494. PMID: 37321825, PMCID: PMC10478817, DOI: 10.2967/jnumed.123.265516.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsF-NaF PET/CTCalcific aortic valve diseaseBicuspid aortic valvePET/CTAortic valve calcificationAortic valve diseaseAortic valveAortic stenosisValve calcificationValvular calcificationValve diseaseF-NaFSubset of miceTricuspid aortic valveDevelopment of calcificationSignificant correlationUnderwent echocardiographyMedical therapyHigh prevalencePreclinical modelsMurine modelTherapeutic interventionsAge groupsAutoradiography dataMultimodality imagingPositron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm
Toczek J, Gona K, Liu Y, Ahmad A, Ghim M, Ojha D, Kukreja G, Salarian M, Luehmann H, Heo G, Guzman R, Chaar C, Tellides G, Hassab A, Ye Y, Shoghi K, Zayed M, Gropler R, Sadeghi M. Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2023, 16: e014615. PMID: 36649454, PMCID: PMC9858355, DOI: 10.1161/circimaging.122.014615.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAbdominal aortic aneurysmHuman aortic tissueMMP activityAortic tissueAortic aneurysmMMP inhibitorsMurine modelMatrix metalloproteinasesPositron emission tomography/Toxicology studiesAortic MMP activityPositron emission tomography radioligandAngiotensin II infusionEmission tomography/Murine abdominal aortic aneurysmsBroad-spectrum MMP inhibitorMatrix metalloproteinase activityPositron emission tomography (PET) tracerPositron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyEmission tomography tracerII infusionRisk stratificationTomography/
2022
TRPC1 channels underlie stretch-modulated sarcoplasmic reticulum calcium leak in cardiomyocytes
Streiff M, Corbin A, Ahmad A, Hunter C, Sachse F. TRPC1 channels underlie stretch-modulated sarcoplasmic reticulum calcium leak in cardiomyocytes. Frontiers In Physiology 2022, 13: 1056657. PMID: 36620209, PMCID: PMC9817106, DOI: 10.3389/fphys.2022.1056657.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNeonatal rat ventricular myocytesTransient receptor potentialTRPC1 channelsTRPC1 expressionCardiac diseaseReceptor potentialSarcoplasmic reticulum calcium leakAdenoviral transfectionRat ventricular myocytesSarco/endoplasmic reticulum CaPermeable ion channelsPhysiological roleSR leakPharmacological therapyEndoplasmic reticulum CaCalcium leakMechanosensitive modulationVentricular myocytesWestern blotReticulum CaRT-qPCRTRPC1CardiomyocytesDisease developmentSignificant reductionDifferential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification
Jung JJ, Ahmad AA, Rajendran S, Wei L, Zhang J, Toczek J, Nie L, Kukreja G, Salarian M, Gona K, Ghim M, Chakraborty R, Martin KA, Tellides G, Heistad D, Sadeghi MM. Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification. JACC Basic To Translational Science 2022, 7: 333-345. PMID: 35540096, PMCID: PMC9079798, DOI: 10.1016/j.jacbts.2021.12.006.Peer-Reviewed Original ResearchCitationsAltmetricConceptsBicuspid aortic valveCalcific aortic valve diseaseAortic valve calcificationValve calcificationHuman Calcific Aortic Valve DiseaseAortic valve diseaseValve diseaseAortic valveCAVD progressionTherapeutic targetBone morphogenic proteinMorphogenic proteinMiceCalcificationDCBLD2StenosisExpressionLittermatesDiseaseBMP signalingProgression
2020
Modulation of Calcium Transients in Cardiomyocytes by Transient Receptor Potential Canonical 6 Channels
Ahmad A, Streiff M, Hunter C, Sachse F. Modulation of Calcium Transients in Cardiomyocytes by Transient Receptor Potential Canonical 6 Channels. Frontiers In Physiology 2020, 11: 44. PMID: 32116757, PMCID: PMC7033547, DOI: 10.3389/fphys.2020.00044.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNeonatal rat ventricular myocytesTRPC6 channelsCytosolic calcium concentrationCalcium loadTransient Receptor Potential Canonical 6 ChannelsCalcium transientsCalcium concentrationSarcoplasmic reticulum calcium loadCardiac hypertrophic remodelingActivated T cellsCalcineurin-nuclear factorEnhanced-green fluorescent proteinRat ventricular myocytesNon-selective cation channelsTransient receptor potentialCytosolic calcium transientsHypertrophic remodelingSustained elevationSR calcium loadT cellsIntracellular calciumCardiac hypertrophyCalcium dyeIndo-1Ventricular myocytesLocation and function of transient receptor potential canonical channel 1 in ventricular myocytes
Hu Q, Ahmad A, Seidel T, Hunter C, Streiff M, Nikolova L, Spitzer K, Sachse F. Location and function of transient receptor potential canonical channel 1 in ventricular myocytes. Journal Of Molecular And Cellular Cardiology 2020, 139: 113-123. PMID: 31982426, PMCID: PMC7085981, DOI: 10.1016/j.yjmcc.2020.01.008.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNeonatal rat ventricular myocytesRabbit ventricular myocytesVentricular myocytesSarcoplasmic reticulumChannel blocker SKF-96365TRPC1 overexpressionTransient receptor potential canonical channel 1Physiological pacing ratesTRPC1 channelsAdult rabbit ventricular myocytesRole of TRPC1Rat ventricular myocytesSarco/endoplasmic reticulum CaTransient receptor potentialMammalian ventricular myocytesIsolated rabbit cardiomyocytesEndoplasmic reticulum CaSKF-96365Free solutionCardiac hypertrophyPacing rateAction potentialsTRPC channelsTransverse tubular systemReticulum Ca
2017
Physiological and pathophysiological role of transient receptor potential canonical channels in cardiac myocytes
Ahmad A, Streiff M, Hunter C, Hu Q, Sachse F. Physiological and pathophysiological role of transient receptor potential canonical channels in cardiac myocytes. Progress In Biophysics And Molecular Biology 2017, 130: 254-263. PMID: 28629808, DOI: 10.1016/j.pbiomolbio.2017.06.005.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTransient receptor potential canonical (TRPC) channelsTRPC channelsCanonical channelsHypertrophic signalingCardiac pathophysiologyPhysiological rolePermeable ion channelsNon-cardiac cellsPathophysiological roleCardiac diseaseHeart rateTopic of controversyTRPC activityPharmacological toolsSuggested physiological rolesCardiac physiologyCardiac myocytesMammalian heartCardiac cellsPathophysiologyPrecise roleTRPC1HeartIon channelsCell typesSheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading
Seidel T, Navankasattusas S, Ahmad A, Diakos N, Xu W, Tristani-Firouzi M, Bonios M, Taleb I, Li D, Selzman C, Drakos S, Sachse F. Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading. Circulation 2017, 135: 1632-1645. PMID: 28073805, PMCID: PMC5404964, DOI: 10.1161/circulationaha.116.024470.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdultAgedBiopsyCase-Control StudiesEchocardiographyExcitation Contraction CouplingFemaleHeart FailureHeart-Assist DevicesHumansImage Processing, Computer-AssistedMaleMicroscopy, ConfocalMiddle AgedMyocardial ContractionMyocytes, CardiacProspective StudiesProsthesis DesignRecovery of FunctionRyanodine Receptor Calcium Release ChannelTime FactorsTreatment OutcomeVentricular Function, LeftVentricular RemodelingConceptsLeft ventricular assist deviceChronic heart failureHeart failureExcitation-contraction couplingCardiac recoveryMechanical unloadingLVAD implantationEjection fractionFunctional recoveryHF myocytesImplantation of LVADHallmark of HFHuman end-stage heart failureLeft ventricular ejection fractionEnd-stage heart failureTransverse tubular systemEnd-stage human heart failureEjection fraction increaseIsolated human cardiomyocytesVentricular ejection fractionSubgroup of patientsVolume/length ratioHuman heart failureFunctional cardiac recoveryVentricular assist device
News & Links
News
- April 17, 2023Source: It's Your Yale
How to Extend a Helping Hand
- September 12, 2022
Feher receives ASNC Best Clinical Abstract Award
- October 11, 2021
Ahmad receives ASNC young investigator award