2018
Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning
Allsop S, Wichmann R, Mills F, Burgos-Robles A, Chang C, Felix-Ortiz A, Vienne A, Beyeler A, Izadmehr E, Glober G, Cum M, Stergiadou J, Anandalingam K, Farris K, Namburi P, Leppla C, Weddington J, Nieh E, Smith A, Ba D, Brown E, Tye K. Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning. Cell 2018, 173: 1329-1342.e18. PMID: 29731170, PMCID: PMC6345560, DOI: 10.1016/j.cell.2018.04.004.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexObservational fear conditioningFear conditioningBasolateral amygdalaThreat-predictive stimuliAssociative fear conditioningImpaired acquisitionAversive cuesCingulate cortexPredictive cuesDemonstrator mouseCue informationAversive valueObservational learningCuesElectrophysiological recordingsRouting of informationAmygdalaCortexMiceStimuliPunishmentSurvival toolInhibitionEstimating a Separably Markov Random Field from Binary Observations
Zhang Y, Malem-Shinitski N, Allsop S, Tye K, Ba D. Estimating a Separably Markov Random Field from Binary Observations. Neural Computation 2018, 30: 1046-1079. PMID: 29381446, DOI: 10.1162/neco_a_01059.Peer-Reviewed Original ResearchConceptsNeural spiking dataMarkov random fieldLimitation of current methodsLoss of informationSpike dataNeural spikesConditional intensity functionRandom fieldState sequenceRF modelLearning of fearLearningTrial-to-trial dynamicsConditioned stimulusEstimate state-space modelsNeuronsPrefrontal cortexNeural underpinningsAssociative learningBinary observationsComputational toolsNeural activityIntensity functionTrialsCurrent methods
2017
Endocannabinoid Signaling in the Control of Social Behavior
Wei D, Allsop S, Tye K, Piomelli D. Endocannabinoid Signaling in the Control of Social Behavior. Trends In Neurosciences 2017, 40: 385-396. PMID: 28554687, PMCID: PMC5699224, DOI: 10.1016/j.tins.2017.04.005.Peer-Reviewed Original ResearchConceptsSocial behaviorEndocannabinoid signalingG-protein-coupled cannabinoid receptorsEndocannabinoid signaling systemComplex social groupsSocial anxietySocial impairmentNeural basisSocial rewardsCannabinoid receptorsNeural processesEndocannabinoidAnimal modelsEmergent insightsAnxietyRewardBehaviorSocial groupsImpairmentBrainSignaling systemAgonistsMammalian speciesReceptors
2015
Decoding Neural Circuits that Control Compulsive Sucrose Seeking
Nieh E, Matthews G, Allsop S, Presbrey K, Leppla C, Wichmann R, Neve R, Wildes C, Tye K. Decoding Neural Circuits that Control Compulsive Sucrose Seeking. Cell 2015, 160: 528-541. PMID: 25635460, PMCID: PMC4312417, DOI: 10.1016/j.cell.2015.01.003.Peer-Reviewed Original ResearchConceptsVentral tegmental areaVentral tegmental area dopamineNeural circuitsReward-predictive cuesFeeding-related behaviorsSucrose seekingReward omissionReward processingReward availabilityTegmental areaHungry miceGABA neuronsLH neuronsGABAergic projectionsDopamineRewardLearning actionsInhibitory inputsNeuronsTherapeutic interventionsSeekingCuesDisordersGABAFood consumption
2012
Ca2+/calmodulin-dependent protein kinase II is associated with pelvic pain of neurogenic cystitis
Yang W, Rudick C, Hoxha E, Allsop S, Dimitrakoff J, Klumpp D. Ca2+/calmodulin-dependent protein kinase II is associated with pelvic pain of neurogenic cystitis. American Journal Of Physiology. Renal Physiology 2012, 303: f350-f356. PMID: 22647634, PMCID: PMC3433862, DOI: 10.1152/ajprenal.00077.2012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCalcium-Calmodulin-Dependent Protein Kinase Type 2CystitisDose-Response Relationship, DrugFemaleHerpesvirus 1, SuidHyperalgesiaImage Processing, Computer-AssistedImmunohistochemistryInjections, SpinalIsoenzymesMiceMice, Inbred C57BLMicroarray AnalysisPelvic PainPhosphorylationPosterior Horn CellsReal-Time Polymerase Chain ReactionRNARNA, MessengerSpinal CordTranscription, GeneticConceptsSacral spinal cordPelvic painNeurogenic cystitisProtein kinase IISpinal cordDorsal hornAssociated with urothelial lesionsChronic bladder inflammatory diseaseDevelopment of pelvic painMurine neurogenic cystitis modelCaMKII inhibitor KN-93Interstitial cystitis/painful bladder syndromeAssociated with pelvic painCa(2+)/calmodulin-dependent protein kinase IIAbductor caudalis dorsalisProgressive pelvic painPostinfection dayKinase IIInhibitor KN-93Pain-signaling pathwaysFemale C57BL/6J miceCa2+/calmodulin-dependent protein kinase IIPostinfection day 2Pelvic/perineal areaCystitis model
2011
The DABBEC Phenotyping System: towards a mechanistic understanding of CP/CPPS
Allsop SA, Erstad DJ, Brook K, Bhai SF, Cohen JM, Dimitrakoff JD. The DABBEC Phenotyping System: towards a mechanistic understanding of CP/CPPS. Nature Reviews Urology 2011, 8: 107-113. PMID: 21243018, DOI: 10.1038/nrurol.2010.227.Peer-Reviewed Original Research