2023
A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension
Gunawardhana K, Hong L, Rugira T, Uebbing S, Kucharczak J, Mehta S, Karunamuni D, Cabera-Mendoza B, Gandotra N, Scharfe C, Polimanti R, Noonan J, Mani A. A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension. Journal Of Clinical Investigation 2023, 133: e160036. PMID: 36602864, PMCID: PMC9927944, DOI: 10.1172/jci160036.Peer-Reviewed Original ResearchConceptsDevelopment of hypertensionParallel reporter assaysRenin inhibitor aliskirenNeural crest-derived cellsRenin-producing cellsSystems biology approachRNA-seq analysisCell-specific disruptionCrest-derived cellsSmooth muscle cellsMuscle cell proteinsSystemic hypertensionBlood pressureWT miceAntihypertensive drugsBiology approachSuper enhancersFine mappingWT littermatesThird intronMultiple GWASCollagen depositionMouse aortaReporter assaysFate mapping
2017
Wnt signaling, a novel pathway regulating blood pressure? State of the art review
Ziki M, Mani A. Wnt signaling, a novel pathway regulating blood pressure? State of the art review. Atherosclerosis 2017, 262: 171-178. PMID: 28522145, PMCID: PMC5508596, DOI: 10.1016/j.atherosclerosis.2017.05.001.Peer-Reviewed Original ResearchConceptsBP regulationType 2 diabetes mellitusBlood pressure targetsPathogenesis of hypertensionTight BP controlTherapy of hypertensionField of hypertensionReview of PubMedDrug developmentNovel drug developmentAntihypertensive TrialBP controlDifferent metabolic profilesUnique molecular pathwaysPressure targetsBlood pressureDiabetes mellitusMetabolic syndromePatient populationHypertensionStudy populationHeterogeneous diseaseReference listsPrecision Medicine InitiativeContribution of Wnt