Correction of humoral derangements from mutant superoxide dismutase 1 spinal cord
Kim Y, Martinez T, Deshpande D, Drummond J, Provost‐Javier K, Williams A, McGurk J, Maragakis N, Song H, Ming G, Kerr D. Correction of humoral derangements from mutant superoxide dismutase 1 spinal cord. Annals Of Neurology 2006, 60: 716-728. PMID: 17192933, DOI: 10.1002/ana.21034.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisAnimalsAntibodiesCell Line, TransformedCell SurvivalCoculture TechniquesCulture Media, ConditionedDisease Models, AnimalFemaleFree Radical ScavengersHumansInterleukinsMaleMiceMice, TransgenicMotor NeuronsNerve RegenerationNitric OxideOrgan Culture TechniquesSpinal CordSuperoxide DismutaseTreatment OutcomeVascular Endothelial Growth Factor AConceptsStem cell-derived motor neuronsVascular endothelial growth factorEmbryonic stem cell-derived motor neuronsEndothelial growth factorMotor neuronsNeutralizing antibodies to IL-1betaIL-6Levels of vascular endothelial growth factorOrganotypic slicesOrganotypic culturesAntibodies to IL-1betaGrowth factorAxon lengthToxic to motor neuronsAmyotrophic lateral sclerosisTreatment of amyotrophic lateral sclerosisCocultured motor neuronsPresence of reactive oxygen species scavengersCell survivalInterleukin (IL)-1betaSpinal cord organotypic culturesWild-typeOrganotypic slice culturesSecrete high levelsMotor neuron injury