2023
Advances in Cartilage Repair
Azam M, Butler J, Duenes M, McAllister T, Walls R, Gianakos A, Kennedy J. Advances in Cartilage Repair. Orthopedic Clinics Of North America 2023, 54: 227-236. PMID: 36894294, DOI: 10.1016/j.ocl.2022.11.007.Peer-Reviewed Original ResearchConceptsAutologous osteochondral transplantationBone marrow stimulationPoor healing capacityAnkle painUncontained lesionsConservative managementArthroscopic debridementCystic lesionsBiological adjuvantsTraumatic etiologyOsteochondral transplantationInvasive proceduresOsteochondral lesionsLarge lesionsMarrow stimulationAnkle jointLesionsSmall lesionsScaffold-based therapiesHealing capacityPatientsArticular cartilageUnsatisfactory resultsCartilage repairDebridement
2022
Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus—Does Sex Play a Role?
Gianakos A, Okedele O, Mulcahey M, Kerkhoffs G, Kennedy J. Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus—Does Sex Play a Role? The Journal Of Foot & Ankle Surgery 2022, 62: 96-101. PMID: 35753861, DOI: 10.1053/j.jfas.2022.05.005.Peer-Reviewed Original ResearchConceptsAutologous osteochondral transplantationFemale patientsOsteochondral lesionsMale patientsOsteochondral transplantationPotential gender-related differencesCartilage repair tissue (MOCART) scoreMean MOCART scoreAnkle Outcome ScoreMechanism of injuryChronic ankle instabilityTalar osteochondral lesionsGender-related differencesMean FAOSConsecutive patientsMagnetic resonance observationOutcome scoresFunctional outcomeMOCART scoreAnkle instabilityPatientsDemographic dataTissue scoresLesionsRehabilitation strategiesGender Differences May Exist in the Presentation, Mechanism of Injury and Outcomes Following Bone Marrow Stimulation for Osteochondral Lesions of the Talus
Gianakos A, Williamson E, Mercer N, Kerkhoffs G, Kennedy J. Gender Differences May Exist in the Presentation, Mechanism of Injury and Outcomes Following Bone Marrow Stimulation for Osteochondral Lesions of the Talus. The Journal Of Foot & Ankle Surgery 2022, 62: 75-79. PMID: 35659478, DOI: 10.1053/j.jfas.2022.04.010.Peer-Reviewed Original ResearchConceptsBone marrow stimulationMale patientsFemale patientsPain scoresOsteochondral lesionsMarrow stimulationCartilage repair tissue (MOCART) scoreSymptomatic osteochondral lesionsAnkle Outcome ScoreShort Form-12Mechanism of injuryMagnetic resonance observationYears postsurgeryClinical outcomesOutcome scoresSurgical outcomesRetrospective analysisAnkle biomechanicsPatientsMedial lesionsLateral lesionsLesionsTissue scoresCartilage morphologyOutcomesThe Pregnant Patient – Why Do My Feet Hurt?
Gianakos A, Abdelmoneim A, Kerkhoffs G, DiGiovanni C. The Pregnant Patient – Why Do My Feet Hurt? The Journal Of Foot & Ankle Surgery 2022, 61: 1357-1361. PMID: 35637071, DOI: 10.1053/j.jfas.2022.04.004.Peer-Reviewed Original ResearchAchilles Paratenon Needle Tendoscopy in the Office Setting
Mercer N, Gianakos A, Kaplan D, Dankert J, Kanakamedala A, Chen J, Colasanti C, Hurley E, Stone J, Kennedy J. Achilles Paratenon Needle Tendoscopy in the Office Setting. Arthroscopy Techniques 2022, 11: e315-e320. PMID: 35256969, PMCID: PMC8897562, DOI: 10.1016/j.eats.2021.10.024.Peer-Reviewed Original ResearchAutologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: Does Gender Impact Outcomes?
Gianakos A, Okedele O, Flynn S, Mulcahey M, Kennedy J. Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: Does Gender Impact Outcomes? Foot & Ankle Orthopaedics 2022, 7: 2473011421s00204. PMCID: PMC8795102, DOI: 10.1177/2473011421s00204.Peer-Reviewed Original ResearchAutologous osteochondral transplantationTalar osteochondral lesionsFemale patientsMale patientsChronic ankle instabilityOsteochondral lesionsOsteochondral transplantationAnkle instabilityKnee donor-site morbidityCartilage repair tissue (MOCART) scoreMean MOCART scoreLonger symptom durationAnkle Outcome ScoreDonor site morbidityMean FAOSFAOS scoresSymptom durationComplication rateConsecutive patientsMagnetic resonance observationOutcome scoresFunctional outcomeRevision surgeryMOCART scorePatientsClinical Outcomes of Peroneal Tendon Tears: A Systematic Review
Mercer N, Gianakos A, Mercurio A, Kennedy J. Clinical Outcomes of Peroneal Tendon Tears: A Systematic Review. Foot & Ankle Orthopaedics 2022, 7: 2473011421s00364. PMCID: PMC8795031, DOI: 10.1177/2473011421s00364.Peer-Reviewed Original ResearchReturn to Play and Clinical Outcomes in the Surgical Treatment of Peroneal Tendon Dislocation and Subluxation
Mercer N, Gianakos A, van Dijk P, Mercurio A, Kerkhoffs G, Kennedy J. Return to Play and Clinical Outcomes in the Surgical Treatment of Peroneal Tendon Dislocation and Subluxation. Foot & Ankle Orthopaedics 2022, 7: 2473011421s00366. PMCID: PMC8793618, DOI: 10.1177/2473011421s00366.Peer-Reviewed Original ResearchPeroneal tendon dislocationTendon dislocationSurgical treatmentClinical outcomesSurgical interventionSystematic reviewWeighted mean timeMean postoperative scoreMean preoperative scoreOverall clinical outcomeCurrent systematic reviewAOFAS scorePreoperative scoresPostoperative scoresMean ageClinical studiesPatientsSubluxationAvailable evidenceMean timeOutcomesTreatmentScoresRepairMonthsChapter 13 Ankle Instability
Gianakos A, Mulcahey M. Chapter 13 Ankle Instability. 2022, 169-176. DOI: 10.1016/b978-0-323-75985-4.00025-8.Peer-Reviewed Original ResearchChronic ankle instabilityAnkle instabilityAnkle injuriesConcomitant intra-articular pathologyLong-term sequelaeLateral ankle injuriesLateral ligamentous complexIntra-articular pathologyLateral ligament complexRepair/reconstructionConservative treatmentOperative interventionAnkle sprainMost injuriesRisk factorsHigh success ratePhysical therapyDiagnostic modalitiesLigamentous complexProper diagnosisLigament complexFunctional instabilityInjurySuccess ratePatients
2021
Clinical Outcomes of Peroneal Tendon Tears: A Systematic Review
Mercer N, Gianakos A, Mercurio A, Kennedy J. Clinical Outcomes of Peroneal Tendon Tears: A Systematic Review. The Journal Of Foot & Ankle Surgery 2021, 60: 1008-1013. PMID: 33785239, DOI: 10.1053/j.jfas.2021.03.003.Peer-Reviewed Original Research
2020
Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: Does Gender Impact Outcomes?
Gianakos A, Okedele O, Flynn S, Kennedy J, DiGiovanni C. Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: Does Gender Impact Outcomes? Foot & Ankle Orthopaedics 2020, 5: 2473011420s00227. PMCID: PMC8696434, DOI: 10.1177/2473011420s00227.Peer-Reviewed Original ResearchAutologous osteochondral transplantationFemale patientsTalar osteochondral lesionsOsteochondral lesionsMale patientsMOCART scoreOsteochondral transplantationKnee donor-site morbidityCartilage repair tissue (MOCART) scoreMean MOCART scoreLonger symptom durationAnkle Outcome ScoreDonor site morbidityMean FAOSSymptom durationFAOS scoresComplication rateConsecutive patientsMagnetic resonance observationOutcome scoresFunctional outcomeMean MRIRevision surgeryPatientsLesion sizeOutcomes Following Microfracture for Osteochondral Lesions of the Talus in Female Patients
Williamson E, Gianakos A, Hurley E, Kennedy J. Outcomes Following Microfracture for Osteochondral Lesions of the Talus in Female Patients. Foot & Ankle Orthopaedics 2020, 5: 2473011420s00495. PMCID: PMC8696304, DOI: 10.1177/2473011420s00495.Peer-Reviewed Original ResearchMagnetic resonance imagingCartilage repair tissueFemale patientsMOCART scoreOsteochondral lesionsPostoperative FAOS scoresSymptomatic osteochondral lesionsMean patient ageAnkle Outcome ScoreShort Form-12Treatment of OLTSF-12 scoresLong-term outcomesRepair tissueBone marrow stimulationFAOS scoresFurther surgeryMagnetic resonance observationPatient ageClinical outcomesOutcome scoresTerm outcomesDistraction arthroplastyRetrospective analysisPatientsEffect of Microfracture on Functional Outcomes and Subchondral Sclerosis Following Distraction Arthroplasty of the Ankle Joint
Gianakos A, Haring R, Shimozono Y, Fragomen A, Kennedy J. Effect of Microfracture on Functional Outcomes and Subchondral Sclerosis Following Distraction Arthroplasty of the Ankle Joint. Foot & Ankle International 2020, 41: 631-638. PMID: 32354229, DOI: 10.1177/1071100720917144.Peer-Reviewed Original ResearchConceptsPost-traumatic osteoarthritisDistraction arthroplastyAnkle jointOutcomes of patientsAnkle Outcome ScoreFunctional activity levelBone marrow aspirateFAOS scoresOutcome scoresFunctional outcomeAnkle arthrodesisSubchondral sclerosisBiologic augmentationMarrow aspiratesPatientsLevel IIIPoor candidatesDemographic dataJoint replacementEnd stageArthroplastyAdverse effectsRole of microfracturesActivity levelsSame time intervalSex- and Gender-specific Analysis in Orthopaedic Studies.
Gianakos A, George N, Pinninti A, Kwan S, LaPorte D, Mulcahey M. Sex- and Gender-specific Analysis in Orthopaedic Studies. Clinical Orthopaedics And Related Research® 2020, 478: 1482-1488. PMID: 32281769, PMCID: PMC7310522, DOI: 10.1097/corr.0000000000001172.Peer-Reviewed Original ResearchConceptsGeneral orthopaedic journalsGender-specific analysisSubspecialty journalsOrthopaedic studiesOrthopaedic journalsHealth needsProportion of patientsCase-control studyPrevalence of injuriesWomen's health needsOutcomes of interestMultifactorial statistical modelGreater percentageGender-related differencesInjury patternsDisease progressionOrthopedic injuriesWomen patientsTreatment outcomesOrthopaedic surgery journalsStudy populationProportion of studiesPatientsSports medicineIndividual study levelThe Effects of Diabetes and Diabetic Medications on Bone Health.
Elamir Y, Gianakos A, Lane J, Sharma A, Grist W, Liporace F, Yoon R. The Effects of Diabetes and Diabetic Medications on Bone Health. Journal Of Orthopaedic Trauma 2020, 34: e102-e108. PMID: 31469751, DOI: 10.1097/bot.0000000000001635.Peer-Reviewed Original Research
2019
Metastatic Disease, Myeloma, and Lymphoma Affecting the Hip
Gianakos A, Patel J, Miller J, Sonnylal L, Wittig J. Metastatic Disease, Myeloma, and Lymphoma Affecting the Hip. The Journal Of Hip Surgery 2019, 03: 034-040. DOI: 10.1055/s-0039-1678743.Peer-Reviewed Original ResearchNo difference in outcomes between femoral fixation methods with hamstring autograft in anterior cruciate ligament reconstruction – A network meta-analysis
Hurley E, Gianakos A, Anil U, Strauss E, Gonzalez-Lomas G. No difference in outcomes between femoral fixation methods with hamstring autograft in anterior cruciate ligament reconstruction – A network meta-analysis. The Knee 2019, 26: 292-301. PMID: 30773253, DOI: 10.1016/j.knee.2019.01.015.Peer-Reviewed Original ResearchConceptsAnterior cruciate ligament reconstructionCruciate ligament reconstructionFemoral fixation methodsInterference screwRandomized control trialTendon autograftACL reconstructionLigament reconstructionKnee stabilityFunctional outcomeFemoral fixationRevision proceduresControl trialFixation methodsFemoral fixation techniquesLevel I studiesMean followGraft failureClinical outcomesI studiesPRISMA guidelinesLevel IPatientsAutograftFixation techniques
2018
Differentiating Subchondral Insufficiency Fracture from Osteonecrosis May Help Avoid Unnecessary Total Hip Arthroplasty
Moya-Angeler J, Haring R, Li A, Greditzer IV H, Lane J, Gianakos A. Differentiating Subchondral Insufficiency Fracture from Osteonecrosis May Help Avoid Unnecessary Total Hip Arthroplasty. The Journal Of Hip Surgery 2018, 02: 047-053. DOI: 10.1055/s-0038-1646937.Peer-Reviewed Original ResearchSubchondral insufficiency fractureInsufficiency fracturesClinical featuresMagnetic resonance imaging (MRI) findingsLow signal intensity bandResonance Imaging FindingsX-ray findingsBone mineral densityTotal hip arthroplastyNonoperative managementRadiologic featuresImaging findingsMineral densityOperative procedureHip arthroplastyHigher oddsOsteonecrosisFemoral headMRI analysisBlinded radiologistsPatientsMRI
2015
Bisphosphonate Treatment in Osteoporosis: Optimal Duration of Therapy and the Incorporation of a Drug Holiday
Villa J, Gianakos A, Lane J. Bisphosphonate Treatment in Osteoporosis: Optimal Duration of Therapy and the Incorporation of a Drug Holiday. HSS Journal ® 2015, 12: 66-73. PMID: 26855630, PMCID: PMC4733702, DOI: 10.1007/s11420-015-9469-1.Peer-Reviewed Original ResearchRecent fragility fractureDrug holidayBisphosphonate treatmentFragility fracturesBone deficiencyQuestions/PurposesThe purposeHigh fracture riskBone turnover rateRisk of fractureBone mass measurementsBisphosphonate therapyDrug discontinuationPeer-reviewed journalsCase seriesDrug therapyFracture riskPurposesThe purposeClinical trialsInclusion criteriaCase controlExclusion criteriaMethodsA reviewHuman studiesPatientsElectronic databasesReturn to sports and clinical outcomes in patients treated for peroneal tendon dislocation: a systematic review
van Dijk P, Gianakos A, Kerkhoffs G, Kennedy J. Return to sports and clinical outcomes in patients treated for peroneal tendon dislocation: a systematic review. Knee Surgery, Sports Traumatology, Arthroscopy 2015, 24: 1155-1164. PMID: 26519186, PMCID: PMC4823328, DOI: 10.1007/s00167-015-3833-z.Peer-Reviewed Original ResearchConceptsPeroneal tendon dislocationBest evidence synthesisTendon dislocationSystematic reviewSurgical treatmentPost-operative AOFAS scoresSurgical treatment techniquesLevel IV studiesDifferent surgical treatment techniquesHigh satisfaction rateAOFAS scoreClinical outcomesSurgical managementRedislocation rateEligible studiesLast searchLevel IVBetter outcomesPatientsSatisfaction rateQuicker returnTreatmentHigh satisfactionOutcomesHigh rate