2023
Advances in Cartilage Repair
Azam M, Butler J, Duenes M, McAllister T, Walls R, Gianakos A, Kennedy J. Advances in Cartilage Repair. Orthopedic Clinics Of North America 2023, 54: 227-236. PMID: 36894294, DOI: 10.1016/j.ocl.2022.11.007.Peer-Reviewed Original ResearchConceptsAutologous osteochondral transplantationBone marrow stimulationPoor healing capacityAnkle painUncontained lesionsConservative managementArthroscopic debridementCystic lesionsBiological adjuvantsTraumatic etiologyOsteochondral transplantationInvasive proceduresOsteochondral lesionsLarge lesionsMarrow stimulationAnkle jointLesionsSmall lesionsScaffold-based therapiesHealing capacityPatientsArticular cartilageUnsatisfactory resultsCartilage repairDebridement
2022
Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus—Does Sex Play a Role?
Gianakos A, Okedele O, Mulcahey M, Kerkhoffs G, Kennedy J. Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus—Does Sex Play a Role? The Journal Of Foot & Ankle Surgery 2022, 62: 96-101. PMID: 35753861, DOI: 10.1053/j.jfas.2022.05.005.Peer-Reviewed Original ResearchConceptsAutologous osteochondral transplantationFemale patientsOsteochondral lesionsMale patientsOsteochondral transplantationPotential gender-related differencesCartilage repair tissue (MOCART) scoreMean MOCART scoreAnkle Outcome ScoreMechanism of injuryChronic ankle instabilityTalar osteochondral lesionsGender-related differencesMean FAOSConsecutive patientsMagnetic resonance observationOutcome scoresFunctional outcomeMOCART scoreAnkle instabilityPatientsDemographic dataTissue scoresLesionsRehabilitation strategiesAutologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: Does Gender Impact Outcomes?
Gianakos A, Okedele O, Flynn S, Mulcahey M, Kennedy J. Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: Does Gender Impact Outcomes? Foot & Ankle Orthopaedics 2022, 7: 2473011421s00204. PMCID: PMC8795102, DOI: 10.1177/2473011421s00204.Peer-Reviewed Original ResearchAutologous osteochondral transplantationTalar osteochondral lesionsFemale patientsMale patientsChronic ankle instabilityOsteochondral lesionsOsteochondral transplantationAnkle instabilityKnee donor-site morbidityCartilage repair tissue (MOCART) scoreMean MOCART scoreLonger symptom durationAnkle Outcome ScoreDonor site morbidityMean FAOSFAOS scoresSymptom durationComplication rateConsecutive patientsMagnetic resonance observationOutcome scoresFunctional outcomeRevision surgeryMOCART scorePatientsLong-Term Outcomes of Autograft Osteochondral Transplantation for Osteochondral Lesions of the Talus: Eight to Twelve Years Follow-Up
Gianakos A, Mercer N, Dankert J, Kennedy J. Long-Term Outcomes of Autograft Osteochondral Transplantation for Osteochondral Lesions of the Talus: Eight to Twelve Years Follow-Up. Foot & Ankle Orthopaedics 2022, 7: 2473011421s00206. PMCID: PMC8795146, DOI: 10.1177/2473011421s00206.Peer-Reviewed Original ResearchAutologous osteochondral transplantationPain subscaleRadiographic outcomesOsteochondral transplantationOsteochondral lesionsShort Form-12 (SF-12) general health questionnaireOverall clinical failure rateMean MOCART scoreMean SF-12Ankle Outcome ScoreMean VAS scoreRetrospective case seriesClinical failure rateTreatment of OLTPost-operative MRITotal ankle replacementTreatment of lesionsGeneral Health QuestionnaireQuality of lifeAnkle debridementCartilage repair tissueVAS scoresAdditional surgeryMagnetic resonance observationCase series
2020
Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: Does Gender Impact Outcomes?
Gianakos A, Okedele O, Flynn S, Kennedy J, DiGiovanni C. Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: Does Gender Impact Outcomes? Foot & Ankle Orthopaedics 2020, 5: 2473011420s00227. PMCID: PMC8696434, DOI: 10.1177/2473011420s00227.Peer-Reviewed Original ResearchAutologous osteochondral transplantationFemale patientsTalar osteochondral lesionsOsteochondral lesionsMale patientsMOCART scoreOsteochondral transplantationKnee donor-site morbidityCartilage repair tissue (MOCART) scoreMean MOCART scoreLonger symptom durationAnkle Outcome ScoreDonor site morbidityMean FAOSSymptom durationFAOS scoresComplication rateConsecutive patientsMagnetic resonance observationOutcome scoresFunctional outcomeMean MRIRevision surgeryPatientsLesion sizeAutologous osteochondral transplantation for osteochondral lesions of the talus: high rate of return to play in the athletic population
Seow D, Shimozono Y, Gianakos A, Chiarello E, Mercer N, Hurley E, Kennedy J. Autologous osteochondral transplantation for osteochondral lesions of the talus: high rate of return to play in the athletic population. Knee Surgery, Sports Traumatology, Arthroscopy 2020, 29: 1554-1561. PMID: 32856096, DOI: 10.1007/s00167-020-06216-w.Peer-Reviewed Original ResearchConceptsAutologous osteochondral transplantationQuality of evidenceOLT sizeRehabilitation protocolOsteochondral transplantationAthletic populationOsteochondral lesionsSystematic reviewPre-injury statusCochrane Library databasesLevel of evidencePredictors of returnSpecific eligibility criteriaHigh rateFixed-effects modelLevel IVSurgeons' protocolsLibrary databasesPRISMA guidelinesEligibility criteriaSubsequent rehabilitationIncrease ageMean timeSignificant correlationTransplantation
2019
Return to Play and Rehabilitation Protocols following Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: A Systematic Review and Meta-Analysis
Shimozono Y, Seow D, Gianakos A, Chiarello E, Kennedy J. Return to Play and Rehabilitation Protocols following Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: A Systematic Review and Meta-Analysis. Foot & Ankle Orthopaedics 2019, 4: 2473011419s00392. PMCID: PMC8697143, DOI: 10.1177/2473011419s00392.Peer-Reviewed Original ResearchAutologous osteochondral transplantationModified Coleman Methodology ScoreQuality of evidenceRehabilitation protocolSystematic reviewOsteochondral transplantationOsteochondral lesionsStandardized rehabilitation protocolPercentage of patientsPre-injury statusColeman Methodology ScoreCochrane Library databasesInclusion/exclusion criteriaMeta-Analyses (PRISMA) guidelinesRange of motionPreferred Reporting ItemsSpecific inclusion/exclusion criteriaHigh rateFixed-effects modelOLT sizePartial weightbearingFull weightbearingMethodology ScoreFavorable outcomeAthletic population
2017
Current management of talar osteochondral lesions
Gianakos A, Yasui Y, Hannon C, Kennedy J. Current management of talar osteochondral lesions. World Journal Of Orthopedics 2017, 8: 12-20. PMID: 28144574, PMCID: PMC5241540, DOI: 10.5312/wjo.v8.i1.12.Peer-Reviewed Original ResearchAutologous osteochondral transplantationBone marrow stimulationReparative proceduresOsteochondral lesionsConcentrated bone marrow aspiratePrimary repair proceduresAcute ankle sprainsTreatment of OLTMedium-term resultsBone marrow aspirateTalar osteochondral lesionsDate clinical evidencePlatelet-rich plasmaDiagnostic imaging modalitiesAOT procedureSymptomatic OLTAdjunct therapyClinical evidenceSurgical outcomesAnkle sprainSurgical techniqueTreatment strategiesMarrow aspiratesOsteochondral transplantationLarge lesions
2015
Anterolateral Tibial Osteotomy for Accessing Osteochondral Lesions of the Talus in Autologous Osteochondral Transplantation
Gianakos A, Hannon C, Ross K, Newman H, Egan C, Deyer T, Kennedy J. Anterolateral Tibial Osteotomy for Accessing Osteochondral Lesions of the Talus in Autologous Osteochondral Transplantation. Foot & Ankle International 2015, 36: 531-538. PMID: 25576475, DOI: 10.1177/1071100714563308.Peer-Reviewed Original ResearchConceptsAutologous osteochondral transplantationAnterolateral tibial osteotomyTibial osteotomyOutcome scoresOsteochondral transplantationOsteochondral lesionsMagnetic resonance imaging outcomesCystic osteochondral lesionsPrimary treatment strategyAnkle Outcome ScoreFunctional outcome scoresRetrospective case seriesRecords of patientsSeries of patientsRepair siteRepair tissueAverage MOCART scoreT2 mapping MRIBone marrow stimulationCartilage repair tissuePostoperative footLigament disruptionLimited morbidityMagnetic resonance observationCase series